Inhibitory effects of heartwood extracts of broussonetia kazinoki sieb on the development of atopic dermatitis in NC/Nga mice

Jun Kyoung Lee; Hyekyung Ha; Ho Young Lee; Sang Joon Park; Seung Jeong; Young Jae Choi; Hyeun Kyoo Shin

doi:10.1271/bbb.100138

Inhibitory effects of heartwood extracts of broussonetia kazinoki sieb on the development of atopic dermatitis in NC/Nga mice

Jun Kyoung Lee, Hyekyung Ha, Ho Young Lee, Sang Joon Park, Seung Jeong, Young Jae Choi, Hyeun Kyoo Shin

Department of Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

We investigated the effects of a topically applied extract of the heartwood of Broussonetia kazinoki Sieb (B. kazinoki) on atopic dermatitis (AD)-like skin lesions induced by an extract of the house-dust mite Dermato-phagoides farina in NC/Nga mice. We found that topically applied B. kazinoki extract suppressed the histological manifestations of AD-like skin lesions, and decreased the levels of plasma immunoglobulin E (IgE) and interleukin-4 (IL-4) in the mice. Moreover, B. kazinoki inhibited the induction of thymus-and-activation-regulated chemokine (TARC/CCL17), macrophage-derived chemokine (MDC/CCL22), and regulated-on-activation-normal T cell-expressed-and-secreted chemokine (RANTES/CCL5) in HaCaT cells activated by tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma). In conclusion, our results suggest that B. kazinoki extract has therapeutic advantages in the treatment of AD.

Original language	English
Pages (from-to)	1802-1806
Number of pages	5
Journal	Bioscience, Biotechnology and Biochemistry
Volume	74
Issue number	9
DOIs	https://doi.org/10.1271/bbb.100138
State	Published - 2010

Keywords

Atopic dermatitis
Broussonetia kazinoki sieb
IgE
NC/Nga mice
TARC

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10.1271/bbb.100138

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title = "Inhibitory effects of heartwood extracts of broussonetia kazinoki sieb on the development of atopic dermatitis in NC/Nga mice",

abstract = "We investigated the effects of a topically applied extract of the heartwood of Broussonetia kazinoki Sieb (B. kazinoki) on atopic dermatitis (AD)-like skin lesions induced by an extract of the house-dust mite Dermato-phagoides farina in NC/Nga mice. We found that topically applied B. kazinoki extract suppressed the histological manifestations of AD-like skin lesions, and decreased the levels of plasma immunoglobulin E (IgE) and interleukin-4 (IL-4) in the mice. Moreover, B. kazinoki inhibited the induction of thymus-and-activation-regulated chemokine (TARC/CCL17), macrophage-derived chemokine (MDC/CCL22), and regulated-on-activation-normal T cell-expressed-and-secreted chemokine (RANTES/CCL5) in HaCaT cells activated by tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma). In conclusion, our results suggest that B. kazinoki extract has therapeutic advantages in the treatment of AD.",

keywords = "Atopic dermatitis, Broussonetia kazinoki sieb, IgE, NC/Nga mice, TARC",

author = "Lee, {Jun Kyoung} and Hyekyung Ha and Lee, {Ho Young} and Park, {Sang Joon} and Seung Jeong and Choi, {Young Jae} and Shin, {Hyeun Kyoo}",

year = "2010",

doi = "10.1271/bbb.100138",

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T1 - Inhibitory effects of heartwood extracts of broussonetia kazinoki sieb on the development of atopic dermatitis in NC/Nga mice

AU - Lee, Jun Kyoung

AU - Ha, Hyekyung

AU - Lee, Ho Young

AU - Park, Sang Joon

AU - Jeong, Seung

AU - Choi, Young Jae

AU - Shin, Hyeun Kyoo

PY - 2010

Y1 - 2010

N2 - We investigated the effects of a topically applied extract of the heartwood of Broussonetia kazinoki Sieb (B. kazinoki) on atopic dermatitis (AD)-like skin lesions induced by an extract of the house-dust mite Dermato-phagoides farina in NC/Nga mice. We found that topically applied B. kazinoki extract suppressed the histological manifestations of AD-like skin lesions, and decreased the levels of plasma immunoglobulin E (IgE) and interleukin-4 (IL-4) in the mice. Moreover, B. kazinoki inhibited the induction of thymus-and-activation-regulated chemokine (TARC/CCL17), macrophage-derived chemokine (MDC/CCL22), and regulated-on-activation-normal T cell-expressed-and-secreted chemokine (RANTES/CCL5) in HaCaT cells activated by tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma). In conclusion, our results suggest that B. kazinoki extract has therapeutic advantages in the treatment of AD.

AB - We investigated the effects of a topically applied extract of the heartwood of Broussonetia kazinoki Sieb (B. kazinoki) on atopic dermatitis (AD)-like skin lesions induced by an extract of the house-dust mite Dermato-phagoides farina in NC/Nga mice. We found that topically applied B. kazinoki extract suppressed the histological manifestations of AD-like skin lesions, and decreased the levels of plasma immunoglobulin E (IgE) and interleukin-4 (IL-4) in the mice. Moreover, B. kazinoki inhibited the induction of thymus-and-activation-regulated chemokine (TARC/CCL17), macrophage-derived chemokine (MDC/CCL22), and regulated-on-activation-normal T cell-expressed-and-secreted chemokine (RANTES/CCL5) in HaCaT cells activated by tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma). In conclusion, our results suggest that B. kazinoki extract has therapeutic advantages in the treatment of AD.

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KW - Broussonetia kazinoki sieb

KW - IgE

KW - NC/Nga mice

KW - TARC

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SN - 0916-8451

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SP - 1802

EP - 1806

JO - Bioscience, Biotechnology and Biochemistry

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Inhibitory effects of heartwood extracts of broussonetia kazinoki sieb on the development of atopic dermatitis in NC/Nga mice

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