Inhibitory effects of Tabebuia impetiginosa inner bark extract on platelet aggregation and vascular smooth muscle cell proliferation through suppressions of arachidonic acid liberation and ERK1/2 MAPK activation

Dong Ju Son; Yong Lim; Young Hyun Park; Sung Keun Chang; Yeo Pyo Yun; Jin Tae Hong; Gary R. Takeoka; Kwang Geun Lee; Sung Eun Lee; Mi Ran Kim; Jeong Han Kim; Byeoung Soo Park

doi:10.1016/j.jep.2006.04.016

Inhibitory effects of Tabebuia impetiginosa inner bark extract on platelet aggregation and vascular smooth muscle cell proliferation through suppressions of arachidonic acid liberation and ERK1/2 MAPK activation

Dong Ju Son, Yong Lim, Young Hyun Park, Sung Keun Chang, Yeo Pyo Yun, Jin Tae Hong, Gary R. Takeoka, Kwang Geun Lee, Sung Eun Lee, Mi Ran Kim, Jeong Han Kim, Byeoung Soo Park

School of Applied Bioscience

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The antiplatelet and antiproliferative activities of extract of Tabebuia impetiginosa inner bark (taheebo) were investigated using washed rabbit platelets and cultured rat aortic vascular smooth muscle cells (VSMCs) in vitro. n-Hexane, chloroform and ethyl acetate fractions showed marked and selective inhibition of platelet aggregation induced by collagen and arachidonic acid (AA) in a dose-dependent manner. These fractions, especially the chloroform fraction, also significantly suppressed AA liberation induced by collagen in [³H]AA-labeled rabbit platelets. The fractions, especially the chloroform fraction, potently inhibited cell proliferation and DNA synthesis induced by platelet derived growth factor (PDGF)-BB, and inhibited the levels of phosphorylated extracellular signal regulated kinase (ERK1/2) mitogen activated protein kinase (MAPK) stimulated by PDGF-BB, in the same concentration range that inhibits VSMC proliferation and DNA synthesis.

Original language	English
Pages (from-to)	148-151
Number of pages	4
Journal	Journal of Ethnopharmacology
Volume	108
Issue number	1
DOIs	https://doi.org/10.1016/j.jep.2006.04.016
State	Published - 3 Nov 2006

Keywords

Arachidonic acid
Atherosclerosis
ERK1/2
Platelet aggregation
Taheebo
Vascular smooth muscle cell

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Son, D. J., Lim, Y., Park, Y. H., Chang, S. K., Yun, Y. P., Hong, J. T., Takeoka, G. R., Lee, K. G., Lee, S. E., Kim, M. R., Kim, J. H., & Park, B. S. (2006). Inhibitory effects of Tabebuia impetiginosa inner bark extract on platelet aggregation and vascular smooth muscle cell proliferation through suppressions of arachidonic acid liberation and ERK1/2 MAPK activation. Journal of Ethnopharmacology, 108(1), 148-151. https://doi.org/10.1016/j.jep.2006.04.016

@article{532bf1019bc846c6ad87d31a46a6880e,

title = "Inhibitory effects of Tabebuia impetiginosa inner bark extract on platelet aggregation and vascular smooth muscle cell proliferation through suppressions of arachidonic acid liberation and ERK1/2 MAPK activation",

abstract = "The antiplatelet and antiproliferative activities of extract of Tabebuia impetiginosa inner bark (taheebo) were investigated using washed rabbit platelets and cultured rat aortic vascular smooth muscle cells (VSMCs) in vitro. n-Hexane, chloroform and ethyl acetate fractions showed marked and selective inhibition of platelet aggregation induced by collagen and arachidonic acid (AA) in a dose-dependent manner. These fractions, especially the chloroform fraction, also significantly suppressed AA liberation induced by collagen in [3H]AA-labeled rabbit platelets. The fractions, especially the chloroform fraction, potently inhibited cell proliferation and DNA synthesis induced by platelet derived growth factor (PDGF)-BB, and inhibited the levels of phosphorylated extracellular signal regulated kinase (ERK1/2) mitogen activated protein kinase (MAPK) stimulated by PDGF-BB, in the same concentration range that inhibits VSMC proliferation and DNA synthesis.",

keywords = "Arachidonic acid, Atherosclerosis, ERK1/2, Platelet aggregation, Taheebo, Vascular smooth muscle cell",

author = "Son, {Dong Ju} and Yong Lim and Park, {Young Hyun} and Chang, {Sung Keun} and Yun, {Yeo Pyo} and Hong, {Jin Tae} and Takeoka, {Gary R.} and Lee, {Kwang Geun} and Lee, {Sung Eun} and Kim, {Mi Ran} and Kim, {Jeong Han} and Park, {Byeoung Soo}",

year = "2006",

month = nov,

day = "3",

doi = "10.1016/j.jep.2006.04.016",

language = "English",

volume = "108",

pages = "148--151",

journal = "Journal of Ethnopharmacology",

issn = "0378-8741",

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Son, DJ, Lim, Y, Park, YH, Chang, SK, Yun, YP, Hong, JT, Takeoka, GR, Lee, KG, Lee, SE, Kim, MR, Kim, JH & Park, BS 2006, 'Inhibitory effects of Tabebuia impetiginosa inner bark extract on platelet aggregation and vascular smooth muscle cell proliferation through suppressions of arachidonic acid liberation and ERK1/2 MAPK activation', Journal of Ethnopharmacology, vol. 108, no. 1, pp. 148-151. https://doi.org/10.1016/j.jep.2006.04.016

Inhibitory effects of Tabebuia impetiginosa inner bark extract on platelet aggregation and vascular smooth muscle cell proliferation through suppressions of arachidonic acid liberation and ERK1/2 MAPK activation. / Son, Dong Ju; Lim, Yong; Park, Young Hyun et al.
In: Journal of Ethnopharmacology, Vol. 108, No. 1, 03.11.2006, p. 148-151.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Inhibitory effects of Tabebuia impetiginosa inner bark extract on platelet aggregation and vascular smooth muscle cell proliferation through suppressions of arachidonic acid liberation and ERK1/2 MAPK activation

AU - Son, Dong Ju

AU - Lim, Yong

AU - Park, Young Hyun

AU - Chang, Sung Keun

AU - Yun, Yeo Pyo

AU - Hong, Jin Tae

AU - Takeoka, Gary R.

AU - Lee, Kwang Geun

AU - Lee, Sung Eun

AU - Kim, Mi Ran

AU - Kim, Jeong Han

AU - Park, Byeoung Soo

PY - 2006/11/3

Y1 - 2006/11/3

N2 - The antiplatelet and antiproliferative activities of extract of Tabebuia impetiginosa inner bark (taheebo) were investigated using washed rabbit platelets and cultured rat aortic vascular smooth muscle cells (VSMCs) in vitro. n-Hexane, chloroform and ethyl acetate fractions showed marked and selective inhibition of platelet aggregation induced by collagen and arachidonic acid (AA) in a dose-dependent manner. These fractions, especially the chloroform fraction, also significantly suppressed AA liberation induced by collagen in [3H]AA-labeled rabbit platelets. The fractions, especially the chloroform fraction, potently inhibited cell proliferation and DNA synthesis induced by platelet derived growth factor (PDGF)-BB, and inhibited the levels of phosphorylated extracellular signal regulated kinase (ERK1/2) mitogen activated protein kinase (MAPK) stimulated by PDGF-BB, in the same concentration range that inhibits VSMC proliferation and DNA synthesis.

AB - The antiplatelet and antiproliferative activities of extract of Tabebuia impetiginosa inner bark (taheebo) were investigated using washed rabbit platelets and cultured rat aortic vascular smooth muscle cells (VSMCs) in vitro. n-Hexane, chloroform and ethyl acetate fractions showed marked and selective inhibition of platelet aggregation induced by collagen and arachidonic acid (AA) in a dose-dependent manner. These fractions, especially the chloroform fraction, also significantly suppressed AA liberation induced by collagen in [3H]AA-labeled rabbit platelets. The fractions, especially the chloroform fraction, potently inhibited cell proliferation and DNA synthesis induced by platelet derived growth factor (PDGF)-BB, and inhibited the levels of phosphorylated extracellular signal regulated kinase (ERK1/2) mitogen activated protein kinase (MAPK) stimulated by PDGF-BB, in the same concentration range that inhibits VSMC proliferation and DNA synthesis.

KW - Arachidonic acid

KW - Atherosclerosis

KW - ERK1/2

KW - Platelet aggregation

KW - Taheebo

KW - Vascular smooth muscle cell

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U2 - 10.1016/j.jep.2006.04.016

DO - 10.1016/j.jep.2006.04.016

M3 - Article

C2 - 16766151

AN - SCOPUS:33749325203

SN - 0378-8741

VL - 108

SP - 148

EP - 151

JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

IS - 1

ER -

Inhibitory effects of Tabebuia impetiginosa inner bark extract on platelet aggregation and vascular smooth muscle cell proliferation through suppressions of arachidonic acid liberation and ERK1/2 MAPK activation

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Keywords

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