TY - JOUR
T1 - Inhibitory properties of gracilaria textorii ethanol extract on the inflammatory immune response
AU - Kim, Min Ji
AU - Kim, Koth Bong Woo Ri
AU - Jang, Mi Ran
AU - Im, Moo Hyeog
AU - Cho, Young Je
AU - Ahn, Dong Hyun
N1 - Publisher Copyright:
© 2018, Korean Society of Food Science and Nutrition. All rights reserved.
PY - 2018/4
Y1 - 2018/4
N2 - In this study, the anti-inflammatory effects of ethanol extract from the marine red algal genus Gracilaria textorii were tested against lipopolysaccharide (LPS)-induced activation in RAW 264.7 cells and croton oil-induced ear edema in mice. Both nitric oxide and pro-inflammatory cytokine production in RAW 264.7 cells, which had been stimulated by LPS, were significantly suppressed by G. textorii ethanol extract (GTEE) treatment in a dose-dependent manner. In addition, expression levels of NF-κB signaling-related proteins (NF-κB, iNOS, and COX-2) and the phosphorylation of MAPK family (p38, JNK, and ERK) were reduced by GTEE. Moreover, GTEE administration in a croton oil-induced ear inflammatory murine model markedly attenuated severe local ear edema. Our results clearly indicate that GTEE can be a potential candidate for novel therapeutic natural agents in the inflammatory immune response.
AB - In this study, the anti-inflammatory effects of ethanol extract from the marine red algal genus Gracilaria textorii were tested against lipopolysaccharide (LPS)-induced activation in RAW 264.7 cells and croton oil-induced ear edema in mice. Both nitric oxide and pro-inflammatory cytokine production in RAW 264.7 cells, which had been stimulated by LPS, were significantly suppressed by G. textorii ethanol extract (GTEE) treatment in a dose-dependent manner. In addition, expression levels of NF-κB signaling-related proteins (NF-κB, iNOS, and COX-2) and the phosphorylation of MAPK family (p38, JNK, and ERK) were reduced by GTEE. Moreover, GTEE administration in a croton oil-induced ear inflammatory murine model markedly attenuated severe local ear edema. Our results clearly indicate that GTEE can be a potential candidate for novel therapeutic natural agents in the inflammatory immune response.
KW - Anti-inflammatory activity
KW - Gracilaria textorii
KW - Mitogen activated protein kinases
KW - Nuclear factor-kappa B
UR - http://www.scopus.com/inward/record.url?scp=85046105644&partnerID=8YFLogxK
U2 - 10.3746/jkfn.2018.47.4.387
DO - 10.3746/jkfn.2018.47.4.387
M3 - Article
AN - SCOPUS:85046105644
SN - 1226-3311
VL - 47
SP - 387
EP - 394
JO - Journal of the Korean Society of Food Science and Nutrition
JF - Journal of the Korean Society of Food Science and Nutrition
IS - 4
ER -
