INPP4B-mediated tumor resistance is associated with modulation of glucose metabolism via hexokinase 2 regulation in laryngeal cancer cells

Joong Won Min; Kwang Il Kim; Hyun Ah Kim; Eun Kyu Kim; Woo Chul Noh; Hong Bae Jeon; Dong Hyung Cho; Jeong Su Oh; In Chul Park; Sang Gu Hwang; Jae Sung Kim

doi:10.1016/j.bbrc.2013.09.041

INPP4B-mediated tumor resistance is associated with modulation of glucose metabolism via hexokinase 2 regulation in laryngeal cancer cells

Joong Won Min, Kwang Il Kim, Hyun Ah Kim, Eun Kyu Kim, Woo Chul Noh, Hong Bae Jeon, Dong Hyung Cho, Jeong Su Oh, In Chul Park, Sang Gu Hwang, Jae Sung Kim

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Inositol polyphosphate 4-phosphatase type II (INPP4B) was recently identified as a tumor resistance factor in laryngeal cancer cells. Herein, we show that INPP4B-mediated resistance is associated with increased glycolytic phenotype. INPP4B expression was induced by hypoxia and irradiation. Intriguingly, overexpression of INPP4B enhanced aerobic glycolysis. Of the glycolysis-regulatory genes, hexokinase 2 (HK2) was mainly regulated by INPP4B and this regulation was mediated through the Akt-mTOR pathway. Notably, codepletion of INPP4B and HK2 markedly sensitized radioresistant laryngeal cancer cells to irradiation or anticancer drug. Moreover, INPP4B was significantly associated with HK2 in human laryngeal cancer tissues. Therefore, these results suggest that INPP4B modulates aerobic glycolysis via HK2 regulation in radioresistant laryngeal cancer cells.

Original language	English
Pages (from-to)	137-142
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	440
Issue number	1
DOIs	https://doi.org/10.1016/j.bbrc.2013.09.041
State	Published - 11 Oct 2013

Keywords

Glycolysis
INPP4B
Laryngeal cancer
Tumor resistance

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbrc.2013.09.041

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Min, J. W., Kim, K. I., Kim, H. A., Kim, E. K., Noh, W. C., Jeon, H. B., Cho, D. H., Oh, J. S., Park, I. C., Hwang, S. G., & Kim, J. S. (2013). INPP4B-mediated tumor resistance is associated with modulation of glucose metabolism via hexokinase 2 regulation in laryngeal cancer cells. Biochemical and Biophysical Research Communications, 440(1), 137-142. https://doi.org/10.1016/j.bbrc.2013.09.041

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title = "INPP4B-mediated tumor resistance is associated with modulation of glucose metabolism via hexokinase 2 regulation in laryngeal cancer cells",

abstract = "Inositol polyphosphate 4-phosphatase type II (INPP4B) was recently identified as a tumor resistance factor in laryngeal cancer cells. Herein, we show that INPP4B-mediated resistance is associated with increased glycolytic phenotype. INPP4B expression was induced by hypoxia and irradiation. Intriguingly, overexpression of INPP4B enhanced aerobic glycolysis. Of the glycolysis-regulatory genes, hexokinase 2 (HK2) was mainly regulated by INPP4B and this regulation was mediated through the Akt-mTOR pathway. Notably, codepletion of INPP4B and HK2 markedly sensitized radioresistant laryngeal cancer cells to irradiation or anticancer drug. Moreover, INPP4B was significantly associated with HK2 in human laryngeal cancer tissues. Therefore, these results suggest that INPP4B modulates aerobic glycolysis via HK2 regulation in radioresistant laryngeal cancer cells.",

keywords = "Glycolysis, INPP4B, Laryngeal cancer, Tumor resistance",

author = "Min, {Joong Won} and Kim, {Kwang Il} and Kim, {Hyun Ah} and Kim, {Eun Kyu} and Noh, {Woo Chul} and Jeon, {Hong Bae} and Cho, {Dong Hyung} and Oh, {Jeong Su} and Park, {In Chul} and Hwang, {Sang Gu} and Kim, {Jae Sung}",

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doi = "10.1016/j.bbrc.2013.09.041",

language = "English",

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Min, JW, Kim, KI, Kim, HA, Kim, EK, Noh, WC, Jeon, HB, Cho, DH, Oh, JS, Park, IC, Hwang, SG & Kim, JS 2013, 'INPP4B-mediated tumor resistance is associated with modulation of glucose metabolism via hexokinase 2 regulation in laryngeal cancer cells', Biochemical and Biophysical Research Communications, vol. 440, no. 1, pp. 137-142. https://doi.org/10.1016/j.bbrc.2013.09.041

TY - JOUR

T1 - INPP4B-mediated tumor resistance is associated with modulation of glucose metabolism via hexokinase 2 regulation in laryngeal cancer cells

AU - Min, Joong Won

AU - Kim, Kwang Il

AU - Kim, Hyun Ah

AU - Kim, Eun Kyu

AU - Noh, Woo Chul

AU - Jeon, Hong Bae

AU - Cho, Dong Hyung

AU - Oh, Jeong Su

AU - Park, In Chul

AU - Hwang, Sang Gu

AU - Kim, Jae Sung

PY - 2013/10/11

Y1 - 2013/10/11

N2 - Inositol polyphosphate 4-phosphatase type II (INPP4B) was recently identified as a tumor resistance factor in laryngeal cancer cells. Herein, we show that INPP4B-mediated resistance is associated with increased glycolytic phenotype. INPP4B expression was induced by hypoxia and irradiation. Intriguingly, overexpression of INPP4B enhanced aerobic glycolysis. Of the glycolysis-regulatory genes, hexokinase 2 (HK2) was mainly regulated by INPP4B and this regulation was mediated through the Akt-mTOR pathway. Notably, codepletion of INPP4B and HK2 markedly sensitized radioresistant laryngeal cancer cells to irradiation or anticancer drug. Moreover, INPP4B was significantly associated with HK2 in human laryngeal cancer tissues. Therefore, these results suggest that INPP4B modulates aerobic glycolysis via HK2 regulation in radioresistant laryngeal cancer cells.

AB - Inositol polyphosphate 4-phosphatase type II (INPP4B) was recently identified as a tumor resistance factor in laryngeal cancer cells. Herein, we show that INPP4B-mediated resistance is associated with increased glycolytic phenotype. INPP4B expression was induced by hypoxia and irradiation. Intriguingly, overexpression of INPP4B enhanced aerobic glycolysis. Of the glycolysis-regulatory genes, hexokinase 2 (HK2) was mainly regulated by INPP4B and this regulation was mediated through the Akt-mTOR pathway. Notably, codepletion of INPP4B and HK2 markedly sensitized radioresistant laryngeal cancer cells to irradiation or anticancer drug. Moreover, INPP4B was significantly associated with HK2 in human laryngeal cancer tissues. Therefore, these results suggest that INPP4B modulates aerobic glycolysis via HK2 regulation in radioresistant laryngeal cancer cells.

KW - Glycolysis

KW - INPP4B

KW - Laryngeal cancer

KW - Tumor resistance

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JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 1

ER -

INPP4B-mediated tumor resistance is associated with modulation of glucose metabolism via hexokinase 2 regulation in laryngeal cancer cells

Abstract

Keywords

UN SDGs

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