Insight into the inhibitory potential of metal complexes supported by (E)-2-morpholino-N-(thiophen-2-ylmethylene)ethanamine: synthesis, structural properties, biological evaluation and docking studies

Saira Nayab; Kalsoom Jan; Seung Hyeon Kim; Sa Hyun Kim; Dilawar Farhan Shams; Younghu Son; Minyoung Yoon; Hyosun Lee

doi:10.1039/d4dt00362d

Insight into the inhibitory potential of metal complexes supported by (E)-2-morpholino-N-(thiophen-2-ylmethylene)ethanamine: synthesis, structural properties, biological evaluation and docking studies

Saira Nayab
, Kalsoom Jan
, Seung Hyeon Kim
, Sa Hyun Kim
, Dilawar Farhan Shams
, Younghu Son
, Minyoung Yoon
, Hyosun Lee

Shaheed Benazir Bhutto University
Kyungpook National University
University of Massachusetts Lowell
Abdul Wali Khan University Maradan

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A thiophene-derived Schiff base ligand (E)-2-morpholino-N-(thiophen-2-ylmethylene)ethanamine was used for the synthesis of M(ii) complexes, [TEM(M)X2] (M = Co, Cu, Zn; X = Cl; M = Cd, X = Br). Structural characterization of the synthesized complexes revealed distorted tetrahedral geometry around the M(ii) center. In vitro investigation of the synthesized ligand and its M(ii) complexes showed considerable anti-urease and leishmanicidal potential. The synthesized complexes also exhibited a significant inhibitory effect on urease, with IC₅₀ values in the range of 3.50-8.05 μM. In addition, the docking results were consistent with the experimental results. A preliminary study of human colorectal cancer (HCT), hepatic cancer (HepG2), and breast cancer (MCF-7) cell lines showed marked anticancer activities of these complexes.

Original language	English
Pages (from-to)	11295-11309
Number of pages	15
Journal	Dalton Transactions
Volume	53
Issue number	27
DOIs	https://doi.org/10.1039/d4dt00362d
State	Published - 11 Jun 2024

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10.1039/d4dt00362d

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Nayab, S., Jan, K., Kim, S. H., Kim, S. H., Shams, D. F., Son, Y., Yoon, M., & Lee, H. (2024). Insight into the inhibitory potential of metal complexes supported by (E)-2-morpholino-N-(thiophen-2-ylmethylene)ethanamine: synthesis, structural properties, biological evaluation and docking studies. Dalton Transactions, 53(27), 11295-11309. https://doi.org/10.1039/d4dt00362d

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title = "Insight into the inhibitory potential of metal complexes supported by (E)-2-morpholino-N-(thiophen-2-ylmethylene)ethanamine: synthesis, structural properties, biological evaluation and docking studies",

abstract = "A thiophene-derived Schiff base ligand (E)-2-morpholino-N-(thiophen-2-ylmethylene)ethanamine was used for the synthesis of M(ii) complexes, [TEM(M)X2] (M = Co, Cu, Zn; X = Cl; M = Cd, X = Br). Structural characterization of the synthesized complexes revealed distorted tetrahedral geometry around the M(ii) center. In vitro investigation of the synthesized ligand and its M(ii) complexes showed considerable anti-urease and leishmanicidal potential. The synthesized complexes also exhibited a significant inhibitory effect on urease, with IC50 values in the range of 3.50-8.05 μM. In addition, the docking results were consistent with the experimental results. A preliminary study of human colorectal cancer (HCT), hepatic cancer (HepG2), and breast cancer (MCF-7) cell lines showed marked anticancer activities of these complexes.",

author = "Saira Nayab and Kalsoom Jan and Kim, \{Seung Hyeon\} and Kim, \{Sa Hyun\} and Shams, \{Dilawar Farhan\} and Younghu Son and Minyoung Yoon and Hyosun Lee",

note = "Publisher Copyright: {\textcopyright} 2024 The Royal Society of Chemistry.",

year = "2024",

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doi = "10.1039/d4dt00362d",

language = "English",

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Nayab, S, Jan, K, Kim, SH, Kim, SH, Shams, DF, Son, Y, Yoon, M & Lee, H 2024, 'Insight into the inhibitory potential of metal complexes supported by (E)-2-morpholino-N-(thiophen-2-ylmethylene)ethanamine: synthesis, structural properties, biological evaluation and docking studies', Dalton Transactions, vol. 53, no. 27, pp. 11295-11309. https://doi.org/10.1039/d4dt00362d

Insight into the inhibitory potential of metal complexes supported by (E)-2-morpholino-N-(thiophen-2-ylmethylene)ethanamine: synthesis, structural properties, biological evaluation and docking studies. / Nayab, Saira; Jan, Kalsoom; Kim, Seung Hyeon et al.
In: Dalton Transactions, Vol. 53, No. 27, 11.06.2024, p. 11295-11309.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Insight into the inhibitory potential of metal complexes supported by (E)-2-morpholino-N-(thiophen-2-ylmethylene)ethanamine

T2 - synthesis, structural properties, biological evaluation and docking studies

AU - Nayab, Saira

AU - Jan, Kalsoom

AU - Kim, Seung Hyeon

AU - Kim, Sa Hyun

AU - Shams, Dilawar Farhan

AU - Son, Younghu

AU - Yoon, Minyoung

AU - Lee, Hyosun

PY - 2024/6/11

Y1 - 2024/6/11

N2 - A thiophene-derived Schiff base ligand (E)-2-morpholino-N-(thiophen-2-ylmethylene)ethanamine was used for the synthesis of M(ii) complexes, [TEM(M)X2] (M = Co, Cu, Zn; X = Cl; M = Cd, X = Br). Structural characterization of the synthesized complexes revealed distorted tetrahedral geometry around the M(ii) center. In vitro investigation of the synthesized ligand and its M(ii) complexes showed considerable anti-urease and leishmanicidal potential. The synthesized complexes also exhibited a significant inhibitory effect on urease, with IC50 values in the range of 3.50-8.05 μM. In addition, the docking results were consistent with the experimental results. A preliminary study of human colorectal cancer (HCT), hepatic cancer (HepG2), and breast cancer (MCF-7) cell lines showed marked anticancer activities of these complexes.

AB - A thiophene-derived Schiff base ligand (E)-2-morpholino-N-(thiophen-2-ylmethylene)ethanamine was used for the synthesis of M(ii) complexes, [TEM(M)X2] (M = Co, Cu, Zn; X = Cl; M = Cd, X = Br). Structural characterization of the synthesized complexes revealed distorted tetrahedral geometry around the M(ii) center. In vitro investigation of the synthesized ligand and its M(ii) complexes showed considerable anti-urease and leishmanicidal potential. The synthesized complexes also exhibited a significant inhibitory effect on urease, with IC50 values in the range of 3.50-8.05 μM. In addition, the docking results were consistent with the experimental results. A preliminary study of human colorectal cancer (HCT), hepatic cancer (HepG2), and breast cancer (MCF-7) cell lines showed marked anticancer activities of these complexes.

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ER -

Insight into the inhibitory potential of metal complexes supported by (E)-2-morpholino-N-(thiophen-2-ylmethylene)ethanamine: synthesis, structural properties, biological evaluation and docking studies

Abstract

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