Insulin-like growth factor II induces interleukin-6 expression via NFκB activation in psoriasis

Yoo Wook Kwon, Eun Ryung Jang, You Mie Lee, You Sun Kim, Kyung Sool Kwon, Ho Sun Jang, Chang Keun Oh, Kyu Won Kim

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

IGF-II is known to induce the growth of keratinocytes and the level was significantly elevated in the tissue fluid of psoriatic lesion. However, the role of IGF-II in psoriasis is not well deigned. Because an inflammatory cytokine, interleukin-6 (IL-6) is overexpressed in psoriatic lesions, we explored whether IGF-II has some role in psoriasis through induction of IL-6. Therefore, the expression of IL-6 was analyzed after treatment of IGF-II in primary cultured psoriatic cells and human keratinocyte cell line, HaCaT. We found that IGF-II induced the IL-6 mRNA expression significantly. To investigate the inducing mechanism of IL-6 by IGF-II, we examined the promoter activity of IL-6 and the DNA binding activity of NFκB, a strong regulator of IL-6. Interestingly, IL-6 promoter activity and the binding activity of NFκB were remarkably increased by IGF-II. Western blot data that IκB was reduced by IGF-II significantly suggest that NFκB activation by IGF-II may be mediated through the downregulation of IκB. Therefore, these results suggest a novel role of IGF-II in psoriasis possibly by inducing IL-6 through the activation of NFκB mediated by downregulation of IκB. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)312-317
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume278
Issue number2
DOIs
StatePublished - 19 Nov 2000

Keywords

  • Insulin-like growth factor-II
  • Interleukin-6
  • NFκB
  • Psoriasis

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