TY - JOUR
T1 - Intervention study on the efficacy and safety of Platycodon grandiflorus ethanol extract in overweight or moderately obese adults
T2 - A single-center, randomized, double-blind, placebo-controlled trial
AU - Kim, Ye Jin
AU - Kwon, Eun Young
AU - Kim, Ji Won
AU - Lee, Youngmi
AU - Ryu, Ri
AU - Yun, Jongbok
AU - Kim, Manheun
AU - Choi, Myung Sook
N1 - Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2019/10
Y1 - 2019/10
N2 - Platycodon grandiflorus root extract (PGE) has shown various properties, such as anti-hyperlipidemia, anti-diabetic, and anti-obesity, but mostly in animal studies. Therefore, we conducted a preliminary study on the anti-obesity effect of PGE in 108 Korean adults (aged 20–60 years, 30 kg/m2 ≥ body mass index ≥ 23 kg/m2). The participants were randomly assigned to four groups and were administered the placebo, PGE571 (571 mg as PGE), PGE1142 (1142 mg as PGE), and PGE2855 (2855 mg as PGE), independently, for 12 weeks. Body composition, nutrient intake, computed tomography scan, and plasma adipokines, as well as hepatic/renal function markers, were assessed. The PGE571 group revealed a significant decrease in body fat mass and body fat percentage when compared with the placebo group. Moreover, the total abdominal and subcutaneous fat areas were significantly decreased following PGE (PGE2855 group) supplementation. These results provide useful information on the anti-obesity effect of PGE for overweight and obese adult humans.
AB - Platycodon grandiflorus root extract (PGE) has shown various properties, such as anti-hyperlipidemia, anti-diabetic, and anti-obesity, but mostly in animal studies. Therefore, we conducted a preliminary study on the anti-obesity effect of PGE in 108 Korean adults (aged 20–60 years, 30 kg/m2 ≥ body mass index ≥ 23 kg/m2). The participants were randomly assigned to four groups and were administered the placebo, PGE571 (571 mg as PGE), PGE1142 (1142 mg as PGE), and PGE2855 (2855 mg as PGE), independently, for 12 weeks. Body composition, nutrient intake, computed tomography scan, and plasma adipokines, as well as hepatic/renal function markers, were assessed. The PGE571 group revealed a significant decrease in body fat mass and body fat percentage when compared with the placebo group. Moreover, the total abdominal and subcutaneous fat areas were significantly decreased following PGE (PGE2855 group) supplementation. These results provide useful information on the anti-obesity effect of PGE for overweight and obese adult humans.
KW - Abdominal fat area
KW - BMI
KW - Body fat mass
KW - Platycodon grandiflorus root
UR - http://www.scopus.com/inward/record.url?scp=85073465812&partnerID=8YFLogxK
U2 - 10.3390/nu11102445
DO - 10.3390/nu11102445
M3 - Article
C2 - 31615016
AN - SCOPUS:85073465812
SN - 2072-6643
VL - 11
JO - Nutrients
JF - Nutrients
IS - 10
M1 - 2445
ER -
