Abstract
The regulation of cytosolic calcium concentration is of critical importance in various cellular responses including differentiation. The osteoclast differentiation factor RANKL (receptor activator of nuclear factor kappa B ligand) induces intracellular calcium oscillation, which is believed to be an essential signaling event for osteoclastogenesis as the calcium response triggers activation of NFATc1 (nuclear factor of activated T cells), a master transcription factor for osteoclast differentiation. The oscillation of cytosolic calcium concentrations is a process that requires both calcium elevation and removal. The type 2 IP3 receptor triggered by IP3 generated by activated PLCγ in response to RANK and costimulation was reported to release calcium from internal stores while SERCA2 was suggested to import cytosolic calcium back to internal stores. In addition, plasma membrane calcium channels including TRPV and NCX have been implicated in the regulation of intracellular calcium in osteoclasts. The orchestrated action of the intracellular and plasma membrane proteins involved in calcium transport must be responsible for the calcium oscillation during osteoclast differentiation.
Original language | English |
---|---|
Title of host publication | Osteoimmunology |
Subtitle of host publication | Interactions of the immune and skeletal systems |
Publisher | Springer New York |
Pages | 23-30 |
Number of pages | 8 |
ISBN (Electronic) | 9781461453666 |
ISBN (Print) | 1461453658, 9781461453659 |
DOIs | |
State | Published - 1 Oct 2013 |