Intranasal administration model for evaluating protection against Influenza virus in mice

Soo Won Choi; Ha Na Youn; Wootack Hong; Jae Keun Park; Seong Su Yuk; Jung Hoon Kwon; Jin Yong Noh; Jung Sun Kang; Kyung Jin Cho; Jeoung Jin Ryu; Joong Bok Lee; Seung Yong Park; In Soo Choi; Sang Won Lee; Chang Seon Song

doi:10.4167/jbv.2015.45.1.44

Intranasal administration model for evaluating protection against Influenza virus in mice

Soo Won Choi, Ha Na Youn, Wootack Hong, Jae Keun Park, Seong Su Yuk, Jung Hoon Kwon, Jin Yong Noh, Jung Sun Kang, Kyung Jin Cho, Jeoung Jin Ryu, Joong Bok Lee, Seung Yong Park, In Soo Choi, Sang Won Lee, Chang Seon Song

Department of Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Antiviral activity against Influenza virus of 14 Lactobacillus species isolated from food was monitored. Lactobacillus species were isolated from traditional Korean fermented food. Each live Lactobacillus was administered into the nasal cavity of SPF 6-week-old BALB/c mice. After the Lactobacillus treatment, Influenza virus (A/NWS/33/H1N1) was inoculated to each mouse. Clinical signs and mortality was monitored for 21 days. Each Lactobacillus strain showed various level of antiviral activity against Influenza virus. As a result of this study, this mouse experiment model, including intranasal treatment of live Lactobacillus species, could be effective model in evaluating immunomodulatory response of probiotics against respiratory viruses.

Original language	English
Pages (from-to)	44-50
Number of pages	7
Journal	Journal of Bacteriology and Virology
Volume	45
Issue number	1
DOIs	https://doi.org/10.4167/jbv.2015.45.1.44
State	Published - 2015

Keywords

Animal model
Antiviral
Influenza
Probiotics

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Choi, S. W., Youn, H. N., Hong, W., Park, J. K., Yuk, S. S., Kwon, J. H., Noh, J. Y., Kang, J. S., Cho, K. J., Ryu, J. J., Lee, J. B., Park, S. Y., Choi, I. S., Lee, S. W., & Song, C. S. (2015). Intranasal administration model for evaluating protection against Influenza virus in mice. Journal of Bacteriology and Virology, 45(1), 44-50. https://doi.org/10.4167/jbv.2015.45.1.44

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title = "Intranasal administration model for evaluating protection against Influenza virus in mice",

abstract = "Antiviral activity against Influenza virus of 14 Lactobacillus species isolated from food was monitored. Lactobacillus species were isolated from traditional Korean fermented food. Each live Lactobacillus was administered into the nasal cavity of SPF 6-week-old BALB/c mice. After the Lactobacillus treatment, Influenza virus (A/NWS/33/H1N1) was inoculated to each mouse. Clinical signs and mortality was monitored for 21 days. Each Lactobacillus strain showed various level of antiviral activity against Influenza virus. As a result of this study, this mouse experiment model, including intranasal treatment of live Lactobacillus species, could be effective model in evaluating immunomodulatory response of probiotics against respiratory viruses.",

keywords = "Animal model, Antiviral, Influenza, Probiotics",

author = "Choi, {Soo Won} and Youn, {Ha Na} and Wootack Hong and Park, {Jae Keun} and Yuk, {Seong Su} and Kwon, {Jung Hoon} and Noh, {Jin Yong} and Kang, {Jung Sun} and Cho, {Kyung Jin} and Ryu, {Jeoung Jin} and Lee, {Joong Bok} and Park, {Seung Yong} and Choi, {In Soo} and Lee, {Sang Won} and Song, {Chang Seon}",

year = "2015",

doi = "10.4167/jbv.2015.45.1.44",

language = "English",

volume = "45",

pages = "44--50",

journal = "Journal of Bacteriology and Virology",

issn = "1598-2467",

publisher = "The Korean Society for Mocrobiology / The Korean Society of Virology",

number = "1",

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TY - JOUR

T1 - Intranasal administration model for evaluating protection against Influenza virus in mice

AU - Choi, Soo Won

AU - Youn, Ha Na

AU - Hong, Wootack

AU - Park, Jae Keun

AU - Yuk, Seong Su

AU - Kwon, Jung Hoon

AU - Noh, Jin Yong

AU - Kang, Jung Sun

AU - Cho, Kyung Jin

AU - Ryu, Jeoung Jin

AU - Lee, Joong Bok

AU - Park, Seung Yong

AU - Choi, In Soo

AU - Lee, Sang Won

AU - Song, Chang Seon

PY - 2015

Y1 - 2015

N2 - Antiviral activity against Influenza virus of 14 Lactobacillus species isolated from food was monitored. Lactobacillus species were isolated from traditional Korean fermented food. Each live Lactobacillus was administered into the nasal cavity of SPF 6-week-old BALB/c mice. After the Lactobacillus treatment, Influenza virus (A/NWS/33/H1N1) was inoculated to each mouse. Clinical signs and mortality was monitored for 21 days. Each Lactobacillus strain showed various level of antiviral activity against Influenza virus. As a result of this study, this mouse experiment model, including intranasal treatment of live Lactobacillus species, could be effective model in evaluating immunomodulatory response of probiotics against respiratory viruses.

AB - Antiviral activity against Influenza virus of 14 Lactobacillus species isolated from food was monitored. Lactobacillus species were isolated from traditional Korean fermented food. Each live Lactobacillus was administered into the nasal cavity of SPF 6-week-old BALB/c mice. After the Lactobacillus treatment, Influenza virus (A/NWS/33/H1N1) was inoculated to each mouse. Clinical signs and mortality was monitored for 21 days. Each Lactobacillus strain showed various level of antiviral activity against Influenza virus. As a result of this study, this mouse experiment model, including intranasal treatment of live Lactobacillus species, could be effective model in evaluating immunomodulatory response of probiotics against respiratory viruses.

KW - Animal model

KW - Antiviral

KW - Influenza

KW - Probiotics

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U2 - 10.4167/jbv.2015.45.1.44

DO - 10.4167/jbv.2015.45.1.44

M3 - Article

AN - SCOPUS:84925368092

SN - 1598-2467

VL - 45

SP - 44

EP - 50

JO - Journal of Bacteriology and Virology

JF - Journal of Bacteriology and Virology

IS - 1

ER -

Intranasal administration model for evaluating protection against Influenza virus in mice

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Keywords

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