Intranuclear organization of RUNX transcriptional regulatory machinery in biological control of skeletogenesis and cancer

Gary S. Stein; Jane B. Lian; Janet L. Stein; André J. Van Wijnen; Martin Montecino; Jitesh Pratap; Je Choi; S. Kaleem Zaidi; Amjad Javed; Soraya Gutierrez; Kimberly Harrington; Jiali Shen; Daniel Young

doi:10.1016/S1079-9796(03)00029-9

Intranuclear organization of RUNX transcriptional regulatory machinery in biological control of skeletogenesis and cancer

Gary S. Stein, Jane B. Lian, Janet L. Stein, André J. Van Wijnen, Martin Montecino, Jitesh Pratap, Je Choi, S. Kaleem Zaidi, Amjad Javed, Soraya Gutierrez, Kimberly Harrington, Jiali Shen, Daniel Young

Department of Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

RUNX (AML/CBFA/PEBP2) transcription factors serve as paradigms for obligatory relationships between nuclear structure and physiological control of phenotypic gene expression. The RUNX proteins contribute to tissue restricted transcription by sequence-specific binding to promoter elements of target genes and serving as scaffolds for the assembly of coregulatory complexes that mediate biochemical and architectural control of activity. We will present an overview of approaches we are pursuing to address: (1) the involvement of RUNX proteins in governing competency for protein/DNA and protein/protein interactions at promoter regulatory sequences; (2) the recruitment of RUNX factors to subnuclear sites where the machinery for expression or repression of target genes is organized; and (3) the trafficking and integration of regulatory signals that control RUNX-mediated transcription.

Original language	English
Pages (from-to)	170-176
Number of pages	7
Journal	Blood Cells, Molecules, and Diseases
Volume	30
Issue number	2
DOIs	https://doi.org/10.1016/S1079-9796(03)00029-9
State	Published - 2003

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Stein, G. S., Lian, J. B., Stein, J. L., Van Wijnen, A. J., Montecino, M., Pratap, J., Choi, J., Zaidi, S. K., Javed, A., Gutierrez, S., Harrington, K., Shen, J., & Young, D. (2003). Intranuclear organization of RUNX transcriptional regulatory machinery in biological control of skeletogenesis and cancer. Blood Cells, Molecules, and Diseases, 30(2), 170-176. https://doi.org/10.1016/S1079-9796(03)00029-9

@article{a7584398f4fd4a368a5c2a711ef60eba,

title = "Intranuclear organization of RUNX transcriptional regulatory machinery in biological control of skeletogenesis and cancer",

abstract = "RUNX (AML/CBFA/PEBP2) transcription factors serve as paradigms for obligatory relationships between nuclear structure and physiological control of phenotypic gene expression. The RUNX proteins contribute to tissue restricted transcription by sequence-specific binding to promoter elements of target genes and serving as scaffolds for the assembly of coregulatory complexes that mediate biochemical and architectural control of activity. We will present an overview of approaches we are pursuing to address: (1) the involvement of RUNX proteins in governing competency for protein/DNA and protein/protein interactions at promoter regulatory sequences; (2) the recruitment of RUNX factors to subnuclear sites where the machinery for expression or repression of target genes is organized; and (3) the trafficking and integration of regulatory signals that control RUNX-mediated transcription.",

author = "Stein, {Gary S.} and Lian, {Jane B.} and Stein, {Janet L.} and {Van Wijnen}, {Andr{\'e} J.} and Martin Montecino and Jitesh Pratap and Je Choi and Zaidi, {S. Kaleem} and Amjad Javed and Soraya Gutierrez and Kimberly Harrington and Jiali Shen and Daniel Young",

year = "2003",

doi = "10.1016/S1079-9796(03)00029-9",

language = "English",

volume = "30",

pages = "170--176",

journal = "Blood Cells, Molecules, and Diseases",

issn = "1079-9796",

publisher = "Academic Press Inc.",

number = "2",

}

Stein, GS, Lian, JB, Stein, JL, Van Wijnen, AJ, Montecino, M, Pratap, J, Choi, J, Zaidi, SK, Javed, A, Gutierrez, S, Harrington, K, Shen, J & Young, D 2003, 'Intranuclear organization of RUNX transcriptional regulatory machinery in biological control of skeletogenesis and cancer', Blood Cells, Molecules, and Diseases, vol. 30, no. 2, pp. 170-176. https://doi.org/10.1016/S1079-9796(03)00029-9

TY - JOUR

T1 - Intranuclear organization of RUNX transcriptional regulatory machinery in biological control of skeletogenesis and cancer

AU - Stein, Gary S.

AU - Lian, Jane B.

AU - Stein, Janet L.

AU - Van Wijnen, André J.

AU - Montecino, Martin

AU - Pratap, Jitesh

AU - Choi, Je

AU - Zaidi, S. Kaleem

AU - Javed, Amjad

AU - Gutierrez, Soraya

AU - Harrington, Kimberly

AU - Shen, Jiali

AU - Young, Daniel

PY - 2003

Y1 - 2003

N2 - RUNX (AML/CBFA/PEBP2) transcription factors serve as paradigms for obligatory relationships between nuclear structure and physiological control of phenotypic gene expression. The RUNX proteins contribute to tissue restricted transcription by sequence-specific binding to promoter elements of target genes and serving as scaffolds for the assembly of coregulatory complexes that mediate biochemical and architectural control of activity. We will present an overview of approaches we are pursuing to address: (1) the involvement of RUNX proteins in governing competency for protein/DNA and protein/protein interactions at promoter regulatory sequences; (2) the recruitment of RUNX factors to subnuclear sites where the machinery for expression or repression of target genes is organized; and (3) the trafficking and integration of regulatory signals that control RUNX-mediated transcription.

AB - RUNX (AML/CBFA/PEBP2) transcription factors serve as paradigms for obligatory relationships between nuclear structure and physiological control of phenotypic gene expression. The RUNX proteins contribute to tissue restricted transcription by sequence-specific binding to promoter elements of target genes and serving as scaffolds for the assembly of coregulatory complexes that mediate biochemical and architectural control of activity. We will present an overview of approaches we are pursuing to address: (1) the involvement of RUNX proteins in governing competency for protein/DNA and protein/protein interactions at promoter regulatory sequences; (2) the recruitment of RUNX factors to subnuclear sites where the machinery for expression or repression of target genes is organized; and (3) the trafficking and integration of regulatory signals that control RUNX-mediated transcription.

UR - http://www.scopus.com/inward/record.url?scp=0037624902&partnerID=8YFLogxK

U2 - 10.1016/S1079-9796(03)00029-9

DO - 10.1016/S1079-9796(03)00029-9

M3 - Article

C2 - 12732180

AN - SCOPUS:0037624902

SN - 1079-9796

VL - 30

SP - 170

EP - 176

JO - Blood Cells, Molecules, and Diseases

JF - Blood Cells, Molecules, and Diseases

IS - 2

ER -

Intranuclear organization of RUNX transcriptional regulatory machinery in biological control of skeletogenesis and cancer

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