Investigation of korean plant extracts for potential phytotherapeutic agents against B‐virus hepatitis

T. H. Chung; J. C. Kim; M. K. Kim; S. C. Choi; S. L. Kim; J. M. Chung; I. S. Lee; S. H. Kim; K. S. Hahn; I. P. Lee

doi:10.1002/ptr.2650090609

Investigation of korean plant extracts for potential phytotherapeutic agents against B‐virus hepatitis

T. H. Chung, J. C. Kim, M. K. Kim, S. C. Choi, S. L. Kim, J. M. Chung, I. S. Lee, S. H. Kim, K. S. Hahn, I. P. Lee

Department of Medicine

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

The present study was undertaken to identify potential phytotherapeutic agents among the aqueous extracts of 151 herbal medicinal plants of Korea. Extracts were assayed for (1) binding potency to hepatitis B‐virus surface antigen (HBsAg), and (2) inhibition of serum hepatitis B‐virus DNA polymerase activity. Of the 151 aqueous plant extracts tested, 33 demonstrated a positive precipitation reaction with HBsAg⁺ serum, and 15 of these specifically bound HBsAg in serum as well as recombinant HBsAg (Hepavax®). Nine extracts competitively inhibited >80% of anti‐HBsAg antibody binding to Hepavax® HBsAg. Furthermore, nine of these 15 plant extracts also exhibited greater than 25%—50% inhibition of hepatitis B‐virus (HBV) DNA polymerase activity, and also significantly stimulated production of the potent cytokine, tumour necrosis factor (TNF). None of the extract concentrations used altered liver function parameters of normal rats.

Original language	English
Pages (from-to)	429-434
Number of pages	6
Journal	Phytotherapy Research
Volume	9
Issue number	6
DOIs	https://doi.org/10.1002/ptr.2650090609
State	Published - Sep 1995

Keywords

HBV DNA polymerase
human hepatitis B‐virus (HBV)
Korean medicinal plants
tumour necrosis factor

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title = "Investigation of korean plant extracts for potential phytotherapeutic agents against B‐virus hepatitis",

abstract = "The present study was undertaken to identify potential phytotherapeutic agents among the aqueous extracts of 151 herbal medicinal plants of Korea. Extracts were assayed for (1) binding potency to hepatitis B‐virus surface antigen (HBsAg), and (2) inhibition of serum hepatitis B‐virus DNA polymerase activity. Of the 151 aqueous plant extracts tested, 33 demonstrated a positive precipitation reaction with HBsAg+ serum, and 15 of these specifically bound HBsAg in serum as well as recombinant HBsAg (Hepavax{\textregistered}). Nine extracts competitively inhibited >80% of anti‐HBsAg antibody binding to Hepavax{\textregistered} HBsAg. Furthermore, nine of these 15 plant extracts also exhibited greater than 25%—50% inhibition of hepatitis B‐virus (HBV) DNA polymerase activity, and also significantly stimulated production of the potent cytokine, tumour necrosis factor (TNF). None of the extract concentrations used altered liver function parameters of normal rats.",

keywords = "HBV DNA polymerase, human hepatitis B‐virus (HBV), Korean medicinal plants, tumour necrosis factor",

author = "Chung, {T. H.} and Kim, {J. C.} and Kim, {M. K.} and Choi, {S. C.} and Kim, {S. L.} and Chung, {J. M.} and Lee, {I. S.} and Kim, {S. H.} and Hahn, {K. S.} and Lee, {I. P.}",

year = "1995",

month = sep,

doi = "10.1002/ptr.2650090609",

language = "English",

volume = "9",

pages = "429--434",

journal = "Phytotherapy Research",

issn = "0951-418X",

publisher = "John Wiley and Sons Ltd",

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TY - JOUR

T1 - Investigation of korean plant extracts for potential phytotherapeutic agents against B‐virus hepatitis

AU - Chung, T. H.

AU - Kim, J. C.

AU - Kim, M. K.

AU - Choi, S. C.

AU - Kim, S. L.

AU - Chung, J. M.

AU - Lee, I. S.

AU - Kim, S. H.

AU - Hahn, K. S.

AU - Lee, I. P.

PY - 1995/9

Y1 - 1995/9

N2 - The present study was undertaken to identify potential phytotherapeutic agents among the aqueous extracts of 151 herbal medicinal plants of Korea. Extracts were assayed for (1) binding potency to hepatitis B‐virus surface antigen (HBsAg), and (2) inhibition of serum hepatitis B‐virus DNA polymerase activity. Of the 151 aqueous plant extracts tested, 33 demonstrated a positive precipitation reaction with HBsAg+ serum, and 15 of these specifically bound HBsAg in serum as well as recombinant HBsAg (Hepavax®). Nine extracts competitively inhibited >80% of anti‐HBsAg antibody binding to Hepavax® HBsAg. Furthermore, nine of these 15 plant extracts also exhibited greater than 25%—50% inhibition of hepatitis B‐virus (HBV) DNA polymerase activity, and also significantly stimulated production of the potent cytokine, tumour necrosis factor (TNF). None of the extract concentrations used altered liver function parameters of normal rats.

AB - The present study was undertaken to identify potential phytotherapeutic agents among the aqueous extracts of 151 herbal medicinal plants of Korea. Extracts were assayed for (1) binding potency to hepatitis B‐virus surface antigen (HBsAg), and (2) inhibition of serum hepatitis B‐virus DNA polymerase activity. Of the 151 aqueous plant extracts tested, 33 demonstrated a positive precipitation reaction with HBsAg+ serum, and 15 of these specifically bound HBsAg in serum as well as recombinant HBsAg (Hepavax®). Nine extracts competitively inhibited >80% of anti‐HBsAg antibody binding to Hepavax® HBsAg. Furthermore, nine of these 15 plant extracts also exhibited greater than 25%—50% inhibition of hepatitis B‐virus (HBV) DNA polymerase activity, and also significantly stimulated production of the potent cytokine, tumour necrosis factor (TNF). None of the extract concentrations used altered liver function parameters of normal rats.

KW - HBV DNA polymerase

KW - human hepatitis B‐virus (HBV)

KW - Korean medicinal plants

KW - tumour necrosis factor

UR - http://www.scopus.com/inward/record.url?scp=0029049322&partnerID=8YFLogxK

U2 - 10.1002/ptr.2650090609

DO - 10.1002/ptr.2650090609

M3 - Article

AN - SCOPUS:0029049322

SN - 0951-418X

VL - 9

SP - 429

EP - 434

JO - Phytotherapy Research

JF - Phytotherapy Research

IS - 6

ER -

Investigation of korean plant extracts for potential phytotherapeutic agents against B‐virus hepatitis

Abstract

Keywords

UN SDGs

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