Investigation of phenyllactic acid as a potent tyrosinase inhibitor produced by probiotics

Minhye Shin, Van Long Truong, Minjee Lee, Donggyu Kim, Myun Soo Kim, Hana Cho, Young Hoon Jung, Jungwoo Yang, Woo Sik Jeong, Younghoon Kim

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Melanogenesis is responsible for skin pigmentation and the enzymatic browning of foods. Tyrosinases play a major role in melanin synthesis, and many attempts have been made to identify new natural tyrosinase inhibitors, but few have sought to do in microbes. Postbiotics are bioactive compounds produced by the metabolism of probiotics and have been reported to be safe and effective. In this study, we evaluated the tyrosinase inhibitory effects of culture supernatants of probiotics and discovered novel bacterial metabolites that can be used as a potent tyrosinase inhibitor based on metabolomics. Cultures of Bifidobacterium bifidum IDCC 4201 and Lactiplantibacillus plantarum IDCC 3501 showed effective anti-tyrosinase, reduced melanin synthesis, and altered protein expression associated with the melanogenesis pathway. Comparative metabolomics analyses conducted by GC-MS identified metabolites commonly produced by B. bifidum and L. plantarum. Of eight selected metabolites, phenyllactic acid exhibited significant tyrosinase-inhibitory activity. Our findings suggest that applications of probiotic culture supernatants containing high amounts of phenyllactic acid have potential use as anti-melanogenesis agents in food and medicines.

Original languageEnglish
Article number100413
JournalCurrent Research in Food Science
Volume6
DOIs
StatePublished - Jan 2023

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