Isodon japonicus inhibits mast cell-mediated immediate-type allergic reactions

Sang Yong Kim; Yong Gil Choi; Sang Hyun Kim; Hye Young Shin; Moon Kyu Ahn; Hyung Min Kim; Tae Yong Shin

doi:10.1081/IPH-120037725

Isodon japonicus inhibits mast cell-mediated immediate-type allergic reactions

Sang Yong Kim
, Yong Gil Choi
, Sang Hyun Kim
, Hye Young Shin
, Moon Kyu Ahn
, Hyung Min Kim
, Tae Yong Shin

Department of Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The effect of aqueous extract of Isodon japonicus Hara (Labiatae) (IJAE) on mast cell-mediated immediate-type allergic reactions was investigated. IJAE inhibited systemic allergic reaction induced by compound 48/80. When IJAE was pretreated at the same concentrations with systemic allergic reaction test, the plasma histamine levels were reduced in a dose-dependent manner. IJAE also inhibited local allergic reaction activated by anti-dinitrophenyl (DNP) IgE antibody. IJAE dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. IJAE inhibited the secretion of tumor necrosis factor-α (TNF-α) and interleukin (IL)-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated human mast cell line (HMC-1) cells. In addition, the expression of TNF-α mRNA in HMC-1 cells was inhibited by IJAE. These results indicate that IJAE may be beneficial in the regulation of immediate-type allergic reaction.

Original language	English
Pages (from-to)	273-284
Number of pages	12
Journal	Immunopharmacology and Immunotoxicology
Volume	26
Issue number	2
DOIs	https://doi.org/10.1081/IPH-120037725
State	Published - 2004

Keywords

Allergic reaction
Anti-DNP IgE
Compound 48/80
Isodon japonicus
Mast cells
TNF-α mRNA
TNF-αIL-6

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10.1081/IPH-120037725

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title = "Isodon japonicus inhibits mast cell-mediated immediate-type allergic reactions",

abstract = "The effect of aqueous extract of Isodon japonicus Hara (Labiatae) (IJAE) on mast cell-mediated immediate-type allergic reactions was investigated. IJAE inhibited systemic allergic reaction induced by compound 48/80. When IJAE was pretreated at the same concentrations with systemic allergic reaction test, the plasma histamine levels were reduced in a dose-dependent manner. IJAE also inhibited local allergic reaction activated by anti-dinitrophenyl (DNP) IgE antibody. IJAE dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. IJAE inhibited the secretion of tumor necrosis factor-α (TNF-α) and interleukin (IL)-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated human mast cell line (HMC-1) cells. In addition, the expression of TNF-α mRNA in HMC-1 cells was inhibited by IJAE. These results indicate that IJAE may be beneficial in the regulation of immediate-type allergic reaction.",

keywords = "Allergic reaction, Anti-DNP IgE, Compound 48/80, Isodon japonicus, Mast cells, TNF-α mRNA, TNF-αIL-6",

author = "Kim, \{Sang Yong\} and Choi, \{Yong Gil\} and Kim, \{Sang Hyun\} and Shin, \{Hye Young\} and Ahn, \{Moon Kyu\} and Kim, \{Hyung Min\} and Shin, \{Tae Yong\}",

year = "2004",

doi = "10.1081/IPH-120037725",

language = "English",

volume = "26",

pages = "273--284",

journal = "Immunopharmacology and Immunotoxicology",

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AU - Kim, Sang Yong

AU - Choi, Yong Gil

AU - Kim, Sang Hyun

AU - Shin, Hye Young

AU - Ahn, Moon Kyu

AU - Kim, Hyung Min

AU - Shin, Tae Yong

PY - 2004

Y1 - 2004

N2 - The effect of aqueous extract of Isodon japonicus Hara (Labiatae) (IJAE) on mast cell-mediated immediate-type allergic reactions was investigated. IJAE inhibited systemic allergic reaction induced by compound 48/80. When IJAE was pretreated at the same concentrations with systemic allergic reaction test, the plasma histamine levels were reduced in a dose-dependent manner. IJAE also inhibited local allergic reaction activated by anti-dinitrophenyl (DNP) IgE antibody. IJAE dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. IJAE inhibited the secretion of tumor necrosis factor-α (TNF-α) and interleukin (IL)-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated human mast cell line (HMC-1) cells. In addition, the expression of TNF-α mRNA in HMC-1 cells was inhibited by IJAE. These results indicate that IJAE may be beneficial in the regulation of immediate-type allergic reaction.

AB - The effect of aqueous extract of Isodon japonicus Hara (Labiatae) (IJAE) on mast cell-mediated immediate-type allergic reactions was investigated. IJAE inhibited systemic allergic reaction induced by compound 48/80. When IJAE was pretreated at the same concentrations with systemic allergic reaction test, the plasma histamine levels were reduced in a dose-dependent manner. IJAE also inhibited local allergic reaction activated by anti-dinitrophenyl (DNP) IgE antibody. IJAE dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. IJAE inhibited the secretion of tumor necrosis factor-α (TNF-α) and interleukin (IL)-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated human mast cell line (HMC-1) cells. In addition, the expression of TNF-α mRNA in HMC-1 cells was inhibited by IJAE. These results indicate that IJAE may be beneficial in the regulation of immediate-type allergic reaction.

KW - Allergic reaction

KW - Anti-DNP IgE

KW - Compound 48/80

KW - Isodon japonicus

KW - Mast cells

KW - TNF-α mRNA

KW - TNF-αIL-6

UR - https://www.scopus.com/pages/publications/2942608889

U2 - 10.1081/IPH-120037725

DO - 10.1081/IPH-120037725

M3 - Article

C2 - 15209363

AN - SCOPUS:2942608889

SN - 0892-3973

VL - 26

SP - 273

EP - 284

JO - Immunopharmacology and Immunotoxicology

JF - Immunopharmacology and Immunotoxicology

IS - 2

ER -

Isodon japonicus inhibits mast cell-mediated immediate-type allergic reactions

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