Isolation of 5α-reductase inhibitors from Euphorbia jolkinii

Sung Hee Park; Jeong Ah Kim; Xu Guang Hua; Chong Gu Lee; Ji Young Choi; In Suk Oh; Ae Ryang Son; See Ryun Chung; Seung Ho Lee

Isolation of 5α-reductase inhibitors from Euphorbia jolkinii

Sung Hee Park, Jeong Ah Kim, Xu Guang Hua, Chong Gu Lee, Ji Young Choi, In Suk Oh, Ae Ryang Son, See Ryun Chung, Seung Ho Lee

Yeungnam University

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Twenty eight compounds were isolated from the whole plant of Euphorbia jolkinii and evaluated for inhibitory effect on 5α-reductase activity. Among the tested compounds, 1-desgalloyl eugeniin, hippomanin A, euphorbin D, exocoecarianin, rugosin E, and pentagalloyl glucose showed potent inhibitory effect on the enzyme activity. The inhibitory potency of rugosin E and euphorbin D, which are dimeric ellagitannins on 5α-reductase activity, was 7- to 8-fold stronger than that of γ-linolenic acid.

Original language	English
Pages (from-to)	9-16
Number of pages	8
Journal	Korean Journal of Pharmacognosy
Volume	36
Issue number	1
State	Published - Mar 2005

Keywords

5α-reductase inhibitor
Euphorbia jolkinii
Euphorbiaceae
Hydrolysable tannin
Male pattern alopecia

Cite this

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title = "Isolation of 5α-reductase inhibitors from Euphorbia jolkinii",

abstract = "Twenty eight compounds were isolated from the whole plant of Euphorbia jolkinii and evaluated for inhibitory effect on 5α-reductase activity. Among the tested compounds, 1-desgalloyl eugeniin, hippomanin A, euphorbin D, exocoecarianin, rugosin E, and pentagalloyl glucose showed potent inhibitory effect on the enzyme activity. The inhibitory potency of rugosin E and euphorbin D, which are dimeric ellagitannins on 5α-reductase activity, was 7- to 8-fold stronger than that of γ-linolenic acid.",

keywords = "5α-reductase inhibitor, Euphorbia jolkinii, Euphorbiaceae, Hydrolysable tannin, Male pattern alopecia",

author = "Park, {Sung Hee} and Kim, {Jeong Ah} and Hua, {Xu Guang} and Lee, {Chong Gu} and Choi, {Ji Young} and Oh, {In Suk} and Son, {Ae Ryang} and Chung, {See Ryun} and Lee, {Seung Ho}",

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T1 - Isolation of 5α-reductase inhibitors from Euphorbia jolkinii

AU - Park, Sung Hee

AU - Kim, Jeong Ah

AU - Hua, Xu Guang

AU - Lee, Chong Gu

AU - Choi, Ji Young

AU - Oh, In Suk

AU - Son, Ae Ryang

AU - Chung, See Ryun

AU - Lee, Seung Ho

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N2 - Twenty eight compounds were isolated from the whole plant of Euphorbia jolkinii and evaluated for inhibitory effect on 5α-reductase activity. Among the tested compounds, 1-desgalloyl eugeniin, hippomanin A, euphorbin D, exocoecarianin, rugosin E, and pentagalloyl glucose showed potent inhibitory effect on the enzyme activity. The inhibitory potency of rugosin E and euphorbin D, which are dimeric ellagitannins on 5α-reductase activity, was 7- to 8-fold stronger than that of γ-linolenic acid.

AB - Twenty eight compounds were isolated from the whole plant of Euphorbia jolkinii and evaluated for inhibitory effect on 5α-reductase activity. Among the tested compounds, 1-desgalloyl eugeniin, hippomanin A, euphorbin D, exocoecarianin, rugosin E, and pentagalloyl glucose showed potent inhibitory effect on the enzyme activity. The inhibitory potency of rugosin E and euphorbin D, which are dimeric ellagitannins on 5α-reductase activity, was 7- to 8-fold stronger than that of γ-linolenic acid.

KW - 5α-reductase inhibitor

KW - Euphorbia jolkinii

KW - Euphorbiaceae

KW - Hydrolysable tannin

KW - Male pattern alopecia

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JF - Korean Journal of Pharmacognosy

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Isolation of 5α-reductase inhibitors from Euphorbia jolkinii

Abstract

Keywords

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