Isolation of 5α-reductase inhibitors from Euphorbia jolkinii

Sung Hee Park; Jeong Ah Kim; Xu Guang Hua; Chong Gu Lee; Ji Young Choi; In Suk Oh; Ae Ryang Son; See Ryun Chung; Seung Ho Lee

Isolation of 5α-reductase inhibitors from Euphorbia jolkinii

Sung Hee Park
, Jeong Ah Kim
, Xu Guang Hua
, Chong Gu Lee
, Ji Young Choi
, In Suk Oh
, Ae Ryang Son
, See Ryun Chung
, Seung Ho Lee

Yeungnam University

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Twenty eight compounds were isolated from the whole plant of Euphorbia jolkinii and evaluated for inhibitory effect on 5α-reductase activity. Among the tested compounds, 1-desgalloyl eugeniin, hippomanin A, euphorbin D, exocoecarianin, rugosin E, and pentagalloyl glucose showed potent inhibitory effect on the enzyme activity. The inhibitory potency of rugosin E and euphorbin D, which are dimeric ellagitannins on 5α-reductase activity, was 7- to 8-fold stronger than that of γ-linolenic acid.

Original language	English
Pages (from-to)	9-16
Number of pages	8
Journal	Korean Journal of Pharmacognosy
Volume	36
Issue number	1
State	Published - Mar 2005

Keywords

5α-reductase inhibitor
Euphorbia jolkinii
Euphorbiaceae
Hydrolysable tannin
Male pattern alopecia

Cite this

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title = "Isolation of 5α-reductase inhibitors from Euphorbia jolkinii",

abstract = "Twenty eight compounds were isolated from the whole plant of Euphorbia jolkinii and evaluated for inhibitory effect on 5α-reductase activity. Among the tested compounds, 1-desgalloyl eugeniin, hippomanin A, euphorbin D, exocoecarianin, rugosin E, and pentagalloyl glucose showed potent inhibitory effect on the enzyme activity. The inhibitory potency of rugosin E and euphorbin D, which are dimeric ellagitannins on 5α-reductase activity, was 7- to 8-fold stronger than that of γ-linolenic acid.",

keywords = "5α-reductase inhibitor, Euphorbia jolkinii, Euphorbiaceae, Hydrolysable tannin, Male pattern alopecia",

author = "Park, \{Sung Hee\} and Kim, \{Jeong Ah\} and Hua, \{Xu Guang\} and Lee, \{Chong Gu\} and Choi, \{Ji Young\} and Oh, \{In Suk\} and Son, \{Ae Ryang\} and Chung, \{See Ryun\} and Lee, \{Seung Ho\}",

year = "2005",

month = mar,

language = "English",

volume = "36",

pages = "9--16",

journal = "Korean Journal of Pharmacognosy",

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publisher = "Korean Society of Pharmacognosy",

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TY - JOUR

T1 - Isolation of 5α-reductase inhibitors from Euphorbia jolkinii

AU - Park, Sung Hee

AU - Kim, Jeong Ah

AU - Hua, Xu Guang

AU - Lee, Chong Gu

AU - Choi, Ji Young

AU - Oh, In Suk

AU - Son, Ae Ryang

AU - Chung, See Ryun

AU - Lee, Seung Ho

PY - 2005/3

Y1 - 2005/3

N2 - Twenty eight compounds were isolated from the whole plant of Euphorbia jolkinii and evaluated for inhibitory effect on 5α-reductase activity. Among the tested compounds, 1-desgalloyl eugeniin, hippomanin A, euphorbin D, exocoecarianin, rugosin E, and pentagalloyl glucose showed potent inhibitory effect on the enzyme activity. The inhibitory potency of rugosin E and euphorbin D, which are dimeric ellagitannins on 5α-reductase activity, was 7- to 8-fold stronger than that of γ-linolenic acid.

AB - Twenty eight compounds were isolated from the whole plant of Euphorbia jolkinii and evaluated for inhibitory effect on 5α-reductase activity. Among the tested compounds, 1-desgalloyl eugeniin, hippomanin A, euphorbin D, exocoecarianin, rugosin E, and pentagalloyl glucose showed potent inhibitory effect on the enzyme activity. The inhibitory potency of rugosin E and euphorbin D, which are dimeric ellagitannins on 5α-reductase activity, was 7- to 8-fold stronger than that of γ-linolenic acid.

KW - 5α-reductase inhibitor

KW - Euphorbia jolkinii

KW - Euphorbiaceae

KW - Hydrolysable tannin

KW - Male pattern alopecia

UR - https://www.scopus.com/pages/publications/16344394439

M3 - Article

AN - SCOPUS:16344394439

SN - 0253-3073

VL - 36

SP - 9

EP - 16

JO - Korean Journal of Pharmacognosy

JF - Korean Journal of Pharmacognosy

IS - 1

ER -

Isolation of 5α-reductase inhibitors from Euphorbia jolkinii

Abstract

Keywords

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