Isolation of a new homomonoterpene from madhuca pasquieri and effect of isolated compounds on no production

Le Son Hoang; Manh Hung Tran; Van Thu Nguyen; Quynh Mai Thi Ngo; Joo Sang Lee; Seong Soo Rho; Jeong Ah Kim; Jeong Hyung Lee; Mi Hee Woo; Byung Sun Min

doi:10.1177/1934578x1601100608

Isolation of a new homomonoterpene from madhuca pasquieri and effect of isolated compounds on no production

Le Son Hoang, Manh Hung Tran, Van Thu Nguyen, Quynh Mai Thi Ngo, Joo Sang Lee, Seong Soo Rho, Jeong Ah Kim, Jeong Hyung Lee, Mi Hee Woo, Byung Sun Min

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

A new homomonoterpene, 1, 3, 3-trimethyl-7-oxabicyclo[3.1.1]hexa-9-en-10-oic acid, named madhusic acid A (1), together with ten known compounds (2-11) were isolated from the methanolic extract of the dried leaves of Madhuca pasquieri (Dubard) H. J. Lam. The structure of the new compound was elucidated on the basis of 1D, 2D NMR (COSY, HMQC, and HMBC) and mass spectral analyses. We examined the effects of the isolated compounds against LPS-induced NO production in macrophage RAW264.7 cells and compound 2 showed effective activity with an IC₅₀ value of 14.5 μM.

Original language	English
Pages (from-to)	729-732
Number of pages	4
Journal	Natural Product Communications
Volume	11
Issue number	6
DOIs	https://doi.org/10.1177/1934578x1601100608
State	Published - Jun 2016

Keywords

Anti-inflammatory activity
Homomonoterpene
Madhuca pasquieri
RAW 264.7 cells
Sapotaceae

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10.1177/1934578x1601100608

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title = "Isolation of a new homomonoterpene from madhuca pasquieri and effect of isolated compounds on no production",

abstract = "A new homomonoterpene, 1, 3, 3-trimethyl-7-oxabicyclo[3.1.1]hexa-9-en-10-oic acid, named madhusic acid A (1), together with ten known compounds (2-11) were isolated from the methanolic extract of the dried leaves of Madhuca pasquieri (Dubard) H. J. Lam. The structure of the new compound was elucidated on the basis of 1D, 2D NMR (COSY, HMQC, and HMBC) and mass spectral analyses. We examined the effects of the isolated compounds against LPS-induced NO production in macrophage RAW264.7 cells and compound 2 showed effective activity with an IC50 value of 14.5 μM.",

keywords = "Anti-inflammatory activity, Homomonoterpene, Madhuca pasquieri, RAW 264.7 cells, Sapotaceae",

author = "Hoang, {Le Son} and Tran, {Manh Hung} and Nguyen, {Van Thu} and Ngo, {Quynh Mai Thi} and Lee, {Joo Sang} and Rho, {Seong Soo} and Kim, {Jeong Ah} and Lee, {Jeong Hyung} and Woo, {Mi Hee} and Min, {Byung Sun}",

year = "2016",

month = jun,

doi = "10.1177/1934578x1601100608",

language = "English",

volume = "11",

pages = "729--732",

journal = "Natural Product Communications",

issn = "1934-578X",

publisher = "SAGE Publications Inc.",

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T1 - Isolation of a new homomonoterpene from madhuca pasquieri and effect of isolated compounds on no production

AU - Hoang, Le Son

AU - Tran, Manh Hung

AU - Nguyen, Van Thu

AU - Ngo, Quynh Mai Thi

AU - Lee, Joo Sang

AU - Rho, Seong Soo

AU - Kim, Jeong Ah

AU - Lee, Jeong Hyung

AU - Woo, Mi Hee

AU - Min, Byung Sun

PY - 2016/6

Y1 - 2016/6

N2 - A new homomonoterpene, 1, 3, 3-trimethyl-7-oxabicyclo[3.1.1]hexa-9-en-10-oic acid, named madhusic acid A (1), together with ten known compounds (2-11) were isolated from the methanolic extract of the dried leaves of Madhuca pasquieri (Dubard) H. J. Lam. The structure of the new compound was elucidated on the basis of 1D, 2D NMR (COSY, HMQC, and HMBC) and mass spectral analyses. We examined the effects of the isolated compounds against LPS-induced NO production in macrophage RAW264.7 cells and compound 2 showed effective activity with an IC50 value of 14.5 μM.

AB - A new homomonoterpene, 1, 3, 3-trimethyl-7-oxabicyclo[3.1.1]hexa-9-en-10-oic acid, named madhusic acid A (1), together with ten known compounds (2-11) were isolated from the methanolic extract of the dried leaves of Madhuca pasquieri (Dubard) H. J. Lam. The structure of the new compound was elucidated on the basis of 1D, 2D NMR (COSY, HMQC, and HMBC) and mass spectral analyses. We examined the effects of the isolated compounds against LPS-induced NO production in macrophage RAW264.7 cells and compound 2 showed effective activity with an IC50 value of 14.5 μM.

KW - Anti-inflammatory activity

KW - Homomonoterpene

KW - Madhuca pasquieri

KW - RAW 264.7 cells

KW - Sapotaceae

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U2 - 10.1177/1934578x1601100608

DO - 10.1177/1934578x1601100608

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AN - SCOPUS:84989209078

SN - 1934-578X

VL - 11

SP - 729

EP - 732

JO - Natural Product Communications

JF - Natural Product Communications

IS - 6

ER -

Isolation of a new homomonoterpene from madhuca pasquieri and effect of isolated compounds on no production

Abstract

Keywords

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