Isolation of melanogenesis inhibitors from cinnamomi cortex

Hee Wook Jung; Ji Young Choi; Jong Gu Lee; Eun Hyang Choi; Joon Seok Oh; Dong Chun Kim; Jeong Ah Kim; Seong Hee Park; Jong Keun Son; Seung Ho Lee

Isolation of melanogenesis inhibitors from cinnamomi cortex

Hee Wook Jung, Ji Young Choi, Jong Gu Lee, Eun Hyang Choi, Joon Seok Oh, Dong Chun Kim, Jeong Ah Kim, Seong Hee Park, Jong Keun Son, Seung Ho Lee

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Cinnamomi Cortex (Lauraceae), the dried bark of Cinnamomum cassia BLUME, has been used as traditional Chinese medicine for its stomachic, astringent, carminative, antispasmodic, antibacterial, antifungal properties. Four compounds were isolated from the MeOH extract of Cinnamomi Cortex, and their structures were identified as trans-cinnamic acid (1), β-sitosterol (2), bis(2-methylheptyl)phthalate (3), coumarin (4) by comparison of their physical and spectral data with those reported in the literature. These compounds were tested melanogenesis inhibitory effect on B-16 mouse melanoma cell lines. Among them, trans-cinnamic acid (1) showed the most potent inhibitory effect on melanogenesis with IC₅₀ value of 13 μg/ml. Arbutin, positive control, exhibited an IC₅₀ value of 29 μg/ml.

Original language	English
Pages (from-to)	382-386
Number of pages	5
Journal	Korean Journal of Pharmacognosy
Volume	38
Issue number	4
State	Published - Dec 2007

Keywords

Cinnamomi cortex
Melanogenesis inhibitor
Trans-cinnamic acid

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title = "Isolation of melanogenesis inhibitors from cinnamomi cortex",

abstract = "Cinnamomi Cortex (Lauraceae), the dried bark of Cinnamomum cassia BLUME, has been used as traditional Chinese medicine for its stomachic, astringent, carminative, antispasmodic, antibacterial, antifungal properties. Four compounds were isolated from the MeOH extract of Cinnamomi Cortex, and their structures were identified as trans-cinnamic acid (1), β-sitosterol (2), bis(2-methylheptyl)phthalate (3), coumarin (4) by comparison of their physical and spectral data with those reported in the literature. These compounds were tested melanogenesis inhibitory effect on B-16 mouse melanoma cell lines. Among them, trans-cinnamic acid (1) showed the most potent inhibitory effect on melanogenesis with IC50 value of 13 μg/ml. Arbutin, positive control, exhibited an IC50 value of 29 μg/ml.",

keywords = "Cinnamomi cortex, Melanogenesis inhibitor, Trans-cinnamic acid",

author = "Jung, {Hee Wook} and Choi, {Ji Young} and Lee, {Jong Gu} and Choi, {Eun Hyang} and Oh, {Joon Seok} and Kim, {Dong Chun} and Kim, {Jeong Ah} and Park, {Seong Hee} and Son, {Jong Keun} and Lee, {Seung Ho}",

year = "2007",

month = dec,

language = "English",

volume = "38",

pages = "382--386",

journal = "Korean Journal of Pharmacognosy",

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T1 - Isolation of melanogenesis inhibitors from cinnamomi cortex

AU - Jung, Hee Wook

AU - Choi, Ji Young

AU - Lee, Jong Gu

AU - Choi, Eun Hyang

AU - Oh, Joon Seok

AU - Kim, Dong Chun

AU - Kim, Jeong Ah

AU - Park, Seong Hee

AU - Son, Jong Keun

AU - Lee, Seung Ho

PY - 2007/12

Y1 - 2007/12

N2 - Cinnamomi Cortex (Lauraceae), the dried bark of Cinnamomum cassia BLUME, has been used as traditional Chinese medicine for its stomachic, astringent, carminative, antispasmodic, antibacterial, antifungal properties. Four compounds were isolated from the MeOH extract of Cinnamomi Cortex, and their structures were identified as trans-cinnamic acid (1), β-sitosterol (2), bis(2-methylheptyl)phthalate (3), coumarin (4) by comparison of their physical and spectral data with those reported in the literature. These compounds were tested melanogenesis inhibitory effect on B-16 mouse melanoma cell lines. Among them, trans-cinnamic acid (1) showed the most potent inhibitory effect on melanogenesis with IC50 value of 13 μg/ml. Arbutin, positive control, exhibited an IC50 value of 29 μg/ml.

AB - Cinnamomi Cortex (Lauraceae), the dried bark of Cinnamomum cassia BLUME, has been used as traditional Chinese medicine for its stomachic, astringent, carminative, antispasmodic, antibacterial, antifungal properties. Four compounds were isolated from the MeOH extract of Cinnamomi Cortex, and their structures were identified as trans-cinnamic acid (1), β-sitosterol (2), bis(2-methylheptyl)phthalate (3), coumarin (4) by comparison of their physical and spectral data with those reported in the literature. These compounds were tested melanogenesis inhibitory effect on B-16 mouse melanoma cell lines. Among them, trans-cinnamic acid (1) showed the most potent inhibitory effect on melanogenesis with IC50 value of 13 μg/ml. Arbutin, positive control, exhibited an IC50 value of 29 μg/ml.

KW - Cinnamomi cortex

KW - Melanogenesis inhibitor

KW - Trans-cinnamic acid

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M3 - Article

AN - SCOPUS:76649123146

SN - 0253-3073

VL - 38

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EP - 386

JO - Korean Journal of Pharmacognosy

JF - Korean Journal of Pharmacognosy

IS - 4

ER -

Isolation of melanogenesis inhibitors from cinnamomi cortex

Abstract

Keywords

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