Isolation of melanogenesis inhibitors from ponciri fructus

Ae Ryang Son; Ji Young Choi; Jeong Ah Kim; Se Hoon Cho; Xu Guang Hua; Sung Hee Park; See Ryun Chung; Tae Chun Chung; Yurng Dong Jahng; Jong Keun Son; Seung Ho Lee

Isolation of melanogenesis inhibitors from ponciri fructus

Ae Ryang Son, Ji Young Choi, Jeong Ah Kim, Se Hoon Cho, Xu Guang Hua, Sung Hee Park, See Ryun Chung, Tae Chun Chung, Yurng Dong Jahng, Jong Keun Son, Seung Ho Lee

Yeungnam University

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

To develop an whitening cosmetics, we isolated the melanogenesis inhibitors from the unripe fruits of Poncirus trifoliata (Rutaceae). Isolated compounds were identified as poncirin(1), naringin(2), bis(2-methylheptyl)phthalate(3), avenalumic acid methyl ester(4) by comparison of physical and spectral data with those reported in the literature. Among the isolated compounds, bis(2-methylheptyl)phthalate showed most potent inhibitory effect on the melanogenesis in cultured B-16 mouse melanoma cell lines (IC₅₀, 36.8 μM) compared with kojic acid (IC₅₀, 150 μM).

Original language	English
Pages (from-to)	1-8
Number of pages	8
Journal	Korean Journal of Pharmacognosy
Volume	36
Issue number	1
State	Published - Mar 2005

Keywords

Bis(2-methylheptyl)phthalate
Melanogenesis inhibitors
Poncirus trifoliata
Rutaceae
Whitening cosmetics

Cite this

@article{197a9d0dd8cf4177801436910489c217,

title = "Isolation of melanogenesis inhibitors from ponciri fructus",

abstract = "To develop an whitening cosmetics, we isolated the melanogenesis inhibitors from the unripe fruits of Poncirus trifoliata (Rutaceae). Isolated compounds were identified as poncirin(1), naringin(2), bis(2-methylheptyl)phthalate(3), avenalumic acid methyl ester(4) by comparison of physical and spectral data with those reported in the literature. Among the isolated compounds, bis(2-methylheptyl)phthalate showed most potent inhibitory effect on the melanogenesis in cultured B-16 mouse melanoma cell lines (IC50, 36.8 μM) compared with kojic acid (IC50, 150 μM).",

keywords = "Bis(2-methylheptyl)phthalate, Melanogenesis inhibitors, Poncirus trifoliata, Rutaceae, Whitening cosmetics",

author = "Son, {Ae Ryang} and Choi, {Ji Young} and Kim, {Jeong Ah} and Cho, {Se Hoon} and Hua, {Xu Guang} and Park, {Sung Hee} and Chung, {See Ryun} and Chung, {Tae Chun} and Jahng, {Yurng Dong} and Son, {Jong Keun} and Lee, {Seung Ho}",

year = "2005",

month = mar,

language = "English",

volume = "36",

pages = "1--8",

journal = "Korean Journal of Pharmacognosy",

issn = "0253-3073",

publisher = "Korean Society of Pharmacognosy",

number = "1",

}

TY - JOUR

T1 - Isolation of melanogenesis inhibitors from ponciri fructus

AU - Son, Ae Ryang

AU - Choi, Ji Young

AU - Kim, Jeong Ah

AU - Cho, Se Hoon

AU - Hua, Xu Guang

AU - Park, Sung Hee

AU - Chung, See Ryun

AU - Chung, Tae Chun

AU - Jahng, Yurng Dong

AU - Son, Jong Keun

AU - Lee, Seung Ho

PY - 2005/3

Y1 - 2005/3

N2 - To develop an whitening cosmetics, we isolated the melanogenesis inhibitors from the unripe fruits of Poncirus trifoliata (Rutaceae). Isolated compounds were identified as poncirin(1), naringin(2), bis(2-methylheptyl)phthalate(3), avenalumic acid methyl ester(4) by comparison of physical and spectral data with those reported in the literature. Among the isolated compounds, bis(2-methylheptyl)phthalate showed most potent inhibitory effect on the melanogenesis in cultured B-16 mouse melanoma cell lines (IC50, 36.8 μM) compared with kojic acid (IC50, 150 μM).

AB - To develop an whitening cosmetics, we isolated the melanogenesis inhibitors from the unripe fruits of Poncirus trifoliata (Rutaceae). Isolated compounds were identified as poncirin(1), naringin(2), bis(2-methylheptyl)phthalate(3), avenalumic acid methyl ester(4) by comparison of physical and spectral data with those reported in the literature. Among the isolated compounds, bis(2-methylheptyl)phthalate showed most potent inhibitory effect on the melanogenesis in cultured B-16 mouse melanoma cell lines (IC50, 36.8 μM) compared with kojic acid (IC50, 150 μM).

KW - Bis(2-methylheptyl)phthalate

KW - Melanogenesis inhibitors

KW - Poncirus trifoliata

KW - Rutaceae

KW - Whitening cosmetics

UR - http://www.scopus.com/inward/record.url?scp=20144386700&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:20144386700

SN - 0253-3073

VL - 36

SP - 1

EP - 8

JO - Korean Journal of Pharmacognosy

JF - Korean Journal of Pharmacognosy

IS - 1

ER -

Isolation of melanogenesis inhibitors from ponciri fructus

Abstract

Keywords

Other files and links

Fingerprint

Cite this