Isolation of melanogenesis inhibitors from ponciri fructus

Ae Ryang Son; Ji Young Choi; Jeong Ah Kim; Se Hoon Cho; Xu Guang Hua; Sung Hee Park; See Ryun Chung; Tae Chun Chung; Yurng Dong Jahng; Jong Keun Son; Seung Ho Lee

Isolation of melanogenesis inhibitors from ponciri fructus

Ae Ryang Son
, Ji Young Choi
, Jeong Ah Kim
, Se Hoon Cho
, Xu Guang Hua
, Sung Hee Park
, See Ryun Chung
, Tae Chun Chung
, Yurng Dong Jahng
, Jong Keun Son
, Seung Ho Lee

Yeungnam University

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

To develop an whitening cosmetics, we isolated the melanogenesis inhibitors from the unripe fruits of Poncirus trifoliata (Rutaceae). Isolated compounds were identified as poncirin(1), naringin(2), bis(2-methylheptyl)phthalate(3), avenalumic acid methyl ester(4) by comparison of physical and spectral data with those reported in the literature. Among the isolated compounds, bis(2-methylheptyl)phthalate showed most potent inhibitory effect on the melanogenesis in cultured B-16 mouse melanoma cell lines (IC₅₀, 36.8 μM) compared with kojic acid (IC₅₀, 150 μM).

Original language	English
Pages (from-to)	1-8
Number of pages	8
Journal	Korean Journal of Pharmacognosy
Volume	36
Issue number	1
State	Published - Mar 2005

Keywords

Bis(2-methylheptyl)phthalate
Melanogenesis inhibitors
Poncirus trifoliata
Rutaceae
Whitening cosmetics

Cite this

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title = "Isolation of melanogenesis inhibitors from ponciri fructus",

abstract = "To develop an whitening cosmetics, we isolated the melanogenesis inhibitors from the unripe fruits of Poncirus trifoliata (Rutaceae). Isolated compounds were identified as poncirin(1), naringin(2), bis(2-methylheptyl)phthalate(3), avenalumic acid methyl ester(4) by comparison of physical and spectral data with those reported in the literature. Among the isolated compounds, bis(2-methylheptyl)phthalate showed most potent inhibitory effect on the melanogenesis in cultured B-16 mouse melanoma cell lines (IC50, 36.8 μM) compared with kojic acid (IC50, 150 μM).",

keywords = "Bis(2-methylheptyl)phthalate, Melanogenesis inhibitors, Poncirus trifoliata, Rutaceae, Whitening cosmetics",

author = "Son, \{Ae Ryang\} and Choi, \{Ji Young\} and Kim, \{Jeong Ah\} and Cho, \{Se Hoon\} and Hua, \{Xu Guang\} and Park, \{Sung Hee\} and Chung, \{See Ryun\} and Chung, \{Tae Chun\} and Jahng, \{Yurng Dong\} and Son, \{Jong Keun\} and Lee, \{Seung Ho\}",

year = "2005",

month = mar,

language = "English",

volume = "36",

pages = "1--8",

journal = "Korean Journal of Pharmacognosy",

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TY - JOUR

T1 - Isolation of melanogenesis inhibitors from ponciri fructus

AU - Son, Ae Ryang

AU - Choi, Ji Young

AU - Kim, Jeong Ah

AU - Cho, Se Hoon

AU - Hua, Xu Guang

AU - Park, Sung Hee

AU - Chung, See Ryun

AU - Chung, Tae Chun

AU - Jahng, Yurng Dong

AU - Son, Jong Keun

AU - Lee, Seung Ho

PY - 2005/3

Y1 - 2005/3

N2 - To develop an whitening cosmetics, we isolated the melanogenesis inhibitors from the unripe fruits of Poncirus trifoliata (Rutaceae). Isolated compounds were identified as poncirin(1), naringin(2), bis(2-methylheptyl)phthalate(3), avenalumic acid methyl ester(4) by comparison of physical and spectral data with those reported in the literature. Among the isolated compounds, bis(2-methylheptyl)phthalate showed most potent inhibitory effect on the melanogenesis in cultured B-16 mouse melanoma cell lines (IC50, 36.8 μM) compared with kojic acid (IC50, 150 μM).

AB - To develop an whitening cosmetics, we isolated the melanogenesis inhibitors from the unripe fruits of Poncirus trifoliata (Rutaceae). Isolated compounds were identified as poncirin(1), naringin(2), bis(2-methylheptyl)phthalate(3), avenalumic acid methyl ester(4) by comparison of physical and spectral data with those reported in the literature. Among the isolated compounds, bis(2-methylheptyl)phthalate showed most potent inhibitory effect on the melanogenesis in cultured B-16 mouse melanoma cell lines (IC50, 36.8 μM) compared with kojic acid (IC50, 150 μM).

KW - Bis(2-methylheptyl)phthalate

KW - Melanogenesis inhibitors

KW - Poncirus trifoliata

KW - Rutaceae

KW - Whitening cosmetics

UR - https://www.scopus.com/pages/publications/20144386700

M3 - Article

AN - SCOPUS:20144386700

SN - 0253-3073

VL - 36

SP - 1

EP - 8

JO - Korean Journal of Pharmacognosy

JF - Korean Journal of Pharmacognosy

IS - 1

ER -

Isolation of melanogenesis inhibitors from ponciri fructus

Abstract

Keywords

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