Isolation of two new compounds and other constituents from leaves of piper crocatum and study of their soluble epoxide hydrolase activities

Hong Xu Li; Seo Young Yang; Young Ho Kim; Wei Li

doi:10.3390/molecules24030489

Isolation of two new compounds and other constituents from leaves of piper crocatum and study of their soluble epoxide hydrolase activities

Hong Xu Li, Seo Young Yang, Young Ho Kim, Wei Li

Department of Biology Education

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Two new phenolic glucosides, pipercroside A and B (1 and 2), along with 10 known compounds were isolated from the leaves of Piper crocatum Ruiz & Pav. Their chemical structures were elucidated through extensive spectroscopic analyses, including 1D and 2D NMR experiments and HR-ESI-MS analysis and comparison with previously reported data. All the isolated compounds were assessed for soluble epoxide hydrolase (sEH) inhibitory activity. Among them, erigeside II (5) showed inhibitory activity with an IC₅₀ value of 58.5 µM.

Original language	English
Article number	489
Journal	Molecules
Volume	24
Issue number	3
DOIs	https://doi.org/10.3390/molecules24030489
State	Published - 30 Jan 2019

Keywords

Phenolic
Piper crocatum
Piperaceae
Soluble epoxide hydrolase activity

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title = "Isolation of two new compounds and other constituents from leaves of piper crocatum and study of their soluble epoxide hydrolase activities",

abstract = "Two new phenolic glucosides, pipercroside A and B (1 and 2), along with 10 known compounds were isolated from the leaves of Piper crocatum Ruiz & Pav. Their chemical structures were elucidated through extensive spectroscopic analyses, including 1D and 2D NMR experiments and HR-ESI-MS analysis and comparison with previously reported data. All the isolated compounds were assessed for soluble epoxide hydrolase (sEH) inhibitory activity. Among them, erigeside II (5) showed inhibitory activity with an IC50 value of 58.5 µM.",

keywords = "Phenolic, Piper crocatum, Piperaceae, Soluble epoxide hydrolase activity",

author = "Li, {Hong Xu} and Yang, {Seo Young} and Kim, {Young Ho} and Wei Li",

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T1 - Isolation of two new compounds and other constituents from leaves of piper crocatum and study of their soluble epoxide hydrolase activities

AU - Li, Hong Xu

AU - Yang, Seo Young

AU - Kim, Young Ho

AU - Li, Wei

PY - 2019/1/30

Y1 - 2019/1/30

N2 - Two new phenolic glucosides, pipercroside A and B (1 and 2), along with 10 known compounds were isolated from the leaves of Piper crocatum Ruiz & Pav. Their chemical structures were elucidated through extensive spectroscopic analyses, including 1D and 2D NMR experiments and HR-ESI-MS analysis and comparison with previously reported data. All the isolated compounds were assessed for soluble epoxide hydrolase (sEH) inhibitory activity. Among them, erigeside II (5) showed inhibitory activity with an IC50 value of 58.5 µM.

AB - Two new phenolic glucosides, pipercroside A and B (1 and 2), along with 10 known compounds were isolated from the leaves of Piper crocatum Ruiz & Pav. Their chemical structures were elucidated through extensive spectroscopic analyses, including 1D and 2D NMR experiments and HR-ESI-MS analysis and comparison with previously reported data. All the isolated compounds were assessed for soluble epoxide hydrolase (sEH) inhibitory activity. Among them, erigeside II (5) showed inhibitory activity with an IC50 value of 58.5 µM.

KW - Phenolic

KW - Piper crocatum

KW - Piperaceae

KW - Soluble epoxide hydrolase activity

UR - http://www.scopus.com/inward/record.url?scp=85060692529&partnerID=8YFLogxK

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DO - 10.3390/molecules24030489

M3 - Article

C2 - 30704047

AN - SCOPUS:85060692529

SN - 1420-3049

VL - 24

JO - Molecules

JF - Molecules

IS - 3

M1 - 489

ER -

Isolation of two new compounds and other constituents from leaves of piper crocatum and study of their soluble epoxide hydrolase activities

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Keywords

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