Jaceosidin inhibits adipogenesis in 3T3-L1 adipocytes through the PPARγ pathway

Seul Gi Lee; Jongbeom Chae; Jin Soo Kim; Kyoungjin Min; Taeg Kyu Kwon; Ju Ock Nam

doi:10.1177/1934578x1801301014

Jaceosidin inhibits adipogenesis in 3T3-L1 adipocytes through the PPARγ pathway

Seul Gi Lee, Jongbeom Chae, Jin Soo Kim, Kyoungjin Min, Taeg Kyu Kwon, Ju Ock Nam

School of Food Science & Biotechnology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Jaceosidin, a natural flavone, has been reported to have anti-tumorigenic, anti-oxidant, and anti-inflammatory activities. However, the anti-adipogenic effects of jaceosidin have not been investigated. In this study, we demonstrate that jaceosidin suppresses adipocyte differentiation and cellular lipid accumulation without cytotoxicity. Jaceosidin also suppresses the mRNA and protein expression of adipogenesis-related genes. To our knowledge, these results are the first evidence of the anti-adipogenic effects of jaceosidin in 3T3-L1 adipocytes and suggest the use of jaceosidin as a treatment for obesity.

Original language	English
Pages (from-to)	1289-1291
Number of pages	3
Journal	Natural Product Communications
Volume	13
Issue number	10
DOIs	https://doi.org/10.1177/1934578x1801301014
State	Published - Oct 2018

Keywords

3T3-L1 adipocytes
Anti-adipogenic
Jaceosidin
Obesity
Peroxisome proliferator-activated receptor gamma (PPARγ).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/1934578x1801301014

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abstract = "Jaceosidin, a natural flavone, has been reported to have anti-tumorigenic, anti-oxidant, and anti-inflammatory activities. However, the anti-adipogenic effects of jaceosidin have not been investigated. In this study, we demonstrate that jaceosidin suppresses adipocyte differentiation and cellular lipid accumulation without cytotoxicity. Jaceosidin also suppresses the mRNA and protein expression of adipogenesis-related genes. To our knowledge, these results are the first evidence of the anti-adipogenic effects of jaceosidin in 3T3-L1 adipocytes and suggest the use of jaceosidin as a treatment for obesity.",

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doi = "10.1177/1934578x1801301014",

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T1 - Jaceosidin inhibits adipogenesis in 3T3-L1 adipocytes through the PPARγ pathway

AU - Lee, Seul Gi

AU - Chae, Jongbeom

AU - Kim, Jin Soo

AU - Min, Kyoungjin

AU - Kwon, Taeg Kyu

AU - Nam, Ju Ock

PY - 2018/10

Y1 - 2018/10

N2 - Jaceosidin, a natural flavone, has been reported to have anti-tumorigenic, anti-oxidant, and anti-inflammatory activities. However, the anti-adipogenic effects of jaceosidin have not been investigated. In this study, we demonstrate that jaceosidin suppresses adipocyte differentiation and cellular lipid accumulation without cytotoxicity. Jaceosidin also suppresses the mRNA and protein expression of adipogenesis-related genes. To our knowledge, these results are the first evidence of the anti-adipogenic effects of jaceosidin in 3T3-L1 adipocytes and suggest the use of jaceosidin as a treatment for obesity.

AB - Jaceosidin, a natural flavone, has been reported to have anti-tumorigenic, anti-oxidant, and anti-inflammatory activities. However, the anti-adipogenic effects of jaceosidin have not been investigated. In this study, we demonstrate that jaceosidin suppresses adipocyte differentiation and cellular lipid accumulation without cytotoxicity. Jaceosidin also suppresses the mRNA and protein expression of adipogenesis-related genes. To our knowledge, these results are the first evidence of the anti-adipogenic effects of jaceosidin in 3T3-L1 adipocytes and suggest the use of jaceosidin as a treatment for obesity.

KW - 3T3-L1 adipocytes

KW - Anti-adipogenic

KW - Jaceosidin

KW - Obesity

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DO - 10.1177/1934578x1801301014

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Jaceosidin inhibits adipogenesis in 3T3-L1 adipocytes through the PPARγ pathway

Abstract

Keywords

UN SDGs

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