Jujuboside B post-treatment attenuates PM2.5-induced lung injury in mice

Soo Ho Ryu; Nayeon Kim; Chaeyeong Kim; Jong Sup Bae

doi:10.1080/09603123.2022.2102156

Jujuboside B post-treatment attenuates PM_2.5-induced lung injury in mice

Soo Ho Ryu, Nayeon Kim, Chaeyeong Kim, Jong Sup Bae

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Fine particulate matter (PM_2.5) is an air pollutant that causes severe lung injury. We investigated the effects of Jujuboside B (JB), a component of Zizyphi Spinosi Semen, on lung toxicity caused by PM_2.5, and we identified the mechanism of its protective effect. Lung injury in an animal model was induced by intratracheal administration of a PM_2.5 suspension. After 2 days of PM_2.5 pretreatment, mice were administered JB via the tail vein three times over a 2-day period. JB significantly reduced the histological lung damage as well as the lung wet/dry weight ratio. JB also considerably reduced PM_2.5-induced autophagy dysfunction, apoptosis, inflammatory cytokine levels, and the number of PM_2.5-induced lymphocytes in the bronchial alveolar fluid. We conclude that by regulating TLR2, 4-MyD88, and mTOR-autophagy pathways, JB exerts a protective effect on lung injury. Thus, JB can be used as a potential therapeutic agent for PM_2.5-induced lung damage.

Original language	English
Pages (from-to)	1479-1489
Number of pages	11
Journal	International Journal of Environmental Health Research
Volume	33
Issue number	12
DOIs	https://doi.org/10.1080/09603123.2022.2102156
State	Published - 2022

Keywords

4-MyD88
Jujuboside B
lung toxicity
particulate matter
TLR2

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/09603123.2022.2102156

Cite this

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title = "Jujuboside B post-treatment attenuates PM2.5-induced lung injury in mice",

abstract = "Fine particulate matter (PM2.5) is an air pollutant that causes severe lung injury. We investigated the effects of Jujuboside B (JB), a component of Zizyphi Spinosi Semen, on lung toxicity caused by PM2.5, and we identified the mechanism of its protective effect. Lung injury in an animal model was induced by intratracheal administration of a PM2.5 suspension. After 2 days of PM2.5 pretreatment, mice were administered JB via the tail vein three times over a 2-day period. JB significantly reduced the histological lung damage as well as the lung wet/dry weight ratio. JB also considerably reduced PM2.5-induced autophagy dysfunction, apoptosis, inflammatory cytokine levels, and the number of PM2.5-induced lymphocytes in the bronchial alveolar fluid. We conclude that by regulating TLR2, 4-MyD88, and mTOR-autophagy pathways, JB exerts a protective effect on lung injury. Thus, JB can be used as a potential therapeutic agent for PM2.5-induced lung damage.",

keywords = "4-MyD88, Jujuboside B, lung toxicity, particulate matter, TLR2",

author = "Ryu, {Soo Ho} and Nayeon Kim and Chaeyeong Kim and Bae, {Jong Sup}",

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AU - Ryu, Soo Ho

AU - Kim, Nayeon

AU - Kim, Chaeyeong

AU - Bae, Jong Sup

PY - 2022

Y1 - 2022

N2 - Fine particulate matter (PM2.5) is an air pollutant that causes severe lung injury. We investigated the effects of Jujuboside B (JB), a component of Zizyphi Spinosi Semen, on lung toxicity caused by PM2.5, and we identified the mechanism of its protective effect. Lung injury in an animal model was induced by intratracheal administration of a PM2.5 suspension. After 2 days of PM2.5 pretreatment, mice were administered JB via the tail vein three times over a 2-day period. JB significantly reduced the histological lung damage as well as the lung wet/dry weight ratio. JB also considerably reduced PM2.5-induced autophagy dysfunction, apoptosis, inflammatory cytokine levels, and the number of PM2.5-induced lymphocytes in the bronchial alveolar fluid. We conclude that by regulating TLR2, 4-MyD88, and mTOR-autophagy pathways, JB exerts a protective effect on lung injury. Thus, JB can be used as a potential therapeutic agent for PM2.5-induced lung damage.

AB - Fine particulate matter (PM2.5) is an air pollutant that causes severe lung injury. We investigated the effects of Jujuboside B (JB), a component of Zizyphi Spinosi Semen, on lung toxicity caused by PM2.5, and we identified the mechanism of its protective effect. Lung injury in an animal model was induced by intratracheal administration of a PM2.5 suspension. After 2 days of PM2.5 pretreatment, mice were administered JB via the tail vein three times over a 2-day period. JB significantly reduced the histological lung damage as well as the lung wet/dry weight ratio. JB also considerably reduced PM2.5-induced autophagy dysfunction, apoptosis, inflammatory cytokine levels, and the number of PM2.5-induced lymphocytes in the bronchial alveolar fluid. We conclude that by regulating TLR2, 4-MyD88, and mTOR-autophagy pathways, JB exerts a protective effect on lung injury. Thus, JB can be used as a potential therapeutic agent for PM2.5-induced lung damage.

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KW - particulate matter

KW - TLR2

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