Langerhans cell sarcoma of the scalp with concomitant multiple cervical lymph node and adjacent soft tissue involvement: A case report

Man Hoon Han, Jun Young Kim, Weon Ju Lee, Seok Jong Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Currently, the World Health Organization classifies Langerhans cell tumors into Langerhans cell histiocytosis and Langerhans cell sarcoma (LCS). LCS is a neoplastic proliferation of Langerhans cells showing malignant cytological features and aggressive clinical behavior with grave prognosis. Only a few cases have been reported in the available literature; therefore, to date, no definitive treatment has been established. A 64-year-old woman presented with a 1-year history of an asymptomatic, slow-growing erythematous nodule measuring 0.7 cm on her scalp. The patient also reported a 3-month history of a painful swelling on the right side of her neck. Histopathological examination of a scalp biopsy specimen revealed sheets of atypical cells with hyperchromatic nucleoli and clear cytoplasm. Immunohistochemical studies revealed malignant cells positive for CDla, CD31, CD68, and S-100 expression. Additionally, positron emission tomography-computed tomography and fine-needle aspiration revealed LCS of the cervical lymph nodes and surrounding soft tissue. We recommended surgical excision and adjunctive chemotherapy; however, the patient refused treatment and died of the disease 28 months later. (Korean J Dermatol 2019;57(9):538-543).

Original languageEnglish
Pages (from-to)538-543
Number of pages6
JournalKorean Journal of Dermatology
Volume57
Issue number9
StatePublished - Nov 2019

Keywords

  • Langerhans cell sarcoma
  • Lymph node
  • Parotid gland
  • Scalp
  • Soft tissue

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