@inproceedings{b76bb7368f284ca5afbddca6d418e94b,
title = "Laser-generated-focused ultrasound transducers for microbubble-mediated, dual-excitation sonothrombolysis",
abstract = "A laser-generated-focused ultrasound (LGFU) transducer generates high-pressure (up to 20 MPa), high-frequency (>10 MHz) shock waves with a tight focal spot. In this work, we aim to demonstrate the feasibility of using LGFU transducers for sonothrombolysis in vitro. A carbon black LGFU transducer was designed, fabricated and characterized. The prototyped LGFU was applied with in-vitro thrombolysis tests involving microbubble contrast agent (MCA). A conventional piezo ultrasound transducer was used as a secondary excitation source to enhance the cavitation effect by dual-frequency excitation. The in vitro test results showed that microbubble-mediated LGFU treatment can yield the lytic rate of approximately 2 mg/min, suggesting that LGFU transducers may be useful in precision high lytic rate sonothrombolysis.",
keywords = "laser generated focused ultrasound, microbubbles, photoacoustic shock wave, sonothrombolysis",
author = "Jinwook Kim and Chang, {Wei Yi} and Lindsey, {Brooks D.} and Dayton, {Paul A.} and Xuming Dai and Stavas, {Joseph M.} and Xiaoning Jiang",
note = "Publisher Copyright: {\textcopyright} 2016 IEEE.; 2016 IEEE International Ultrasonics Symposium, IUS 2016 ; Conference date: 18-09-2016 Through 21-09-2016",
year = "2016",
month = nov,
day = "1",
doi = "10.1109/ULTSYM.2016.7728473",
language = "English",
series = "IEEE International Ultrasonics Symposium, IUS",
publisher = "IEEE Computer Society",
booktitle = "2016 IEEE International Ultrasonics Symposium, IUS 2016",
address = "United States",
}