Lignans from Kadsura angustifolia

Ye Gao Chen; Guo Wei Qin; Yu Yuan Xie; Kin Fai Cheng; Zhong Wen Lin; Han Dong Sun; Young Hwa Kang; Byung Hoon Han

doi:10.1080/10286029808039854

Lignans from Kadsura angustifolia

Ye Gao Chen, Guo Wei Qin, Yu Yuan Xie, Kin Fai Cheng, Zhong Wen Lin, Han Dong Sun, Young Hwa Kang, Byung Hoon Han

Department of Horticultural Science

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

A new dibenzocyclooctadiene lignan named angustifolin D (1) together with four known lignans: kadsulignan L (2), kadsulignan N (3), schisantherin P (4) and meso-dihydroguaiaretic acid (5) were isolated from the stems of Kadsura angustifolia. Their structures and stereochemistries were elucidated by spectral studies. Compounds 2 and 5 showed moderate platelet-activating factor (PAF) antagonistic activities with IC₅₀ values of 2.6 x 10^-5 and 4.1 x 10^-5 M, respectively.

Original language	English
Pages (from-to)	125-131
Number of pages	7
Journal	Journal of Asian Natural Products Research
Volume	1
Issue number	2
DOIs	https://doi.org/10.1080/10286029808039854
State	Published - 1998

Keywords

Anti-PAF activities
Kadsura angustifolia
Lignan

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10.1080/10286029808039854

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title = "Lignans from Kadsura angustifolia",

abstract = "A new dibenzocyclooctadiene lignan named angustifolin D (1) together with four known lignans: kadsulignan L (2), kadsulignan N (3), schisantherin P (4) and meso-dihydroguaiaretic acid (5) were isolated from the stems of Kadsura angustifolia. Their structures and stereochemistries were elucidated by spectral studies. Compounds 2 and 5 showed moderate platelet-activating factor (PAF) antagonistic activities with IC50 values of 2.6 x 10-5 and 4.1 x 10-5 M, respectively.",

keywords = "Anti-PAF activities, Kadsura angustifolia, Lignan",

author = "Chen, {Ye Gao} and Qin, {Guo Wei} and Xie, {Yu Yuan} and Cheng, {Kin Fai} and Lin, {Zhong Wen} and Sun, {Han Dong} and Kang, {Young Hwa} and Han, {Byung Hoon}",

year = "1998",

doi = "10.1080/10286029808039854",

language = "English",

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journal = "Journal of Asian Natural Products Research",

issn = "1028-6020",

publisher = "Taylor and Francis Ltd.",

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T1 - Lignans from Kadsura angustifolia

AU - Chen, Ye Gao

AU - Qin, Guo Wei

AU - Xie, Yu Yuan

AU - Cheng, Kin Fai

AU - Lin, Zhong Wen

AU - Sun, Han Dong

AU - Kang, Young Hwa

AU - Han, Byung Hoon

PY - 1998

Y1 - 1998

N2 - A new dibenzocyclooctadiene lignan named angustifolin D (1) together with four known lignans: kadsulignan L (2), kadsulignan N (3), schisantherin P (4) and meso-dihydroguaiaretic acid (5) were isolated from the stems of Kadsura angustifolia. Their structures and stereochemistries were elucidated by spectral studies. Compounds 2 and 5 showed moderate platelet-activating factor (PAF) antagonistic activities with IC50 values of 2.6 x 10-5 and 4.1 x 10-5 M, respectively.

AB - A new dibenzocyclooctadiene lignan named angustifolin D (1) together with four known lignans: kadsulignan L (2), kadsulignan N (3), schisantherin P (4) and meso-dihydroguaiaretic acid (5) were isolated from the stems of Kadsura angustifolia. Their structures and stereochemistries were elucidated by spectral studies. Compounds 2 and 5 showed moderate platelet-activating factor (PAF) antagonistic activities with IC50 values of 2.6 x 10-5 and 4.1 x 10-5 M, respectively.

KW - Anti-PAF activities

KW - Kadsura angustifolia

KW - Lignan

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DO - 10.1080/10286029808039854

M3 - Article

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AN - SCOPUS:0032230165

SN - 1028-6020

VL - 1

SP - 125

EP - 131

JO - Journal of Asian Natural Products Research

JF - Journal of Asian Natural Products Research

IS - 2

ER -

Lignans from Kadsura angustifolia

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Keywords

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