Lignans from the fruits of Cornus kousa Burg. and their cytotoxic effects on human cancer cell lines

Dae Young Lee; Myoung Chong Song; Ki Hyun Yoo; Myun Ho Bang; In Sik Chung; Sung Hoon Kim; Dae Keun Kim; Byoung Mog Kwon; Tae Sook Jeong; Mi Hyun Park; Nam In Baek

doi:10.1007/BF02980211

Lignans from the fruits of Cornus kousa Burg. and their cytotoxic effects on human cancer cell lines

Dae Young Lee, Myoung Chong Song, Ki Hyun Yoo, Myun Ho Bang, In Sik Chung, Sung Hoon Kim, Dae Keun Kim, Byoung Mog Kwon, Tae Sook Jeong, Mi Hyun Park, Nam In Baek

School of Life Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

The fruits of Cornus kousa Burg. were extracted with 80% aqueous MeOH, and the concentrated extract partitioned with EtOAc, n-BuOH and H₂O. Six lignans were isolated from the EtOAc fraction through repeated silica gel, ODS and Sephadex LH-20 column chromatographies. From the physico-chemical data, including NMR, MS and IR, the chemical structures of the compounds were determined to be (+)-pinoresinol (1), (-)-balanophonin (2), (+)-laricresinol (3), erythro-guaiacylglycerol-β-coniferyl aldehyde ether (4), threo-guaiacylglycerol-β-coniferyl aldehyde ether (5) and dihydrodehydrodiconiferyl alcohol (6), which were isolated for the first time from this plant. Most of these compounds showed cytotoxicity against human colon carcinoma (HCT-116) and human hepatocellular carcinoma (HepG2) cell lines in vitro, with IC₅₀ values ranging from 19.1 to 71.3 μ g/mL.

Original language	English
Pages (from-to)	402-407
Number of pages	6
Journal	Archives of Pharmacal Research
Volume	30
Issue number	4
DOIs	https://doi.org/10.1007/BF02980211
State	Published - 30 Apr 2007

Keywords

Cornus kousa
Cytotoxicity
Human colon carcinoma (HCT-116)
Human hepatocellular carcinoma (HepG2)
Lignan
MTT assay

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title = "Lignans from the fruits of Cornus kousa Burg. and their cytotoxic effects on human cancer cell lines",

abstract = "The fruits of Cornus kousa Burg. were extracted with 80% aqueous MeOH, and the concentrated extract partitioned with EtOAc, n-BuOH and H2O. Six lignans were isolated from the EtOAc fraction through repeated silica gel, ODS and Sephadex LH-20 column chromatographies. From the physico-chemical data, including NMR, MS and IR, the chemical structures of the compounds were determined to be (+)-pinoresinol (1), (-)-balanophonin (2), (+)-laricresinol (3), erythro-guaiacylglycerol-β-coniferyl aldehyde ether (4), threo-guaiacylglycerol-β-coniferyl aldehyde ether (5) and dihydrodehydrodiconiferyl alcohol (6), which were isolated for the first time from this plant. Most of these compounds showed cytotoxicity against human colon carcinoma (HCT-116) and human hepatocellular carcinoma (HepG2) cell lines in vitro, with IC50 values ranging from 19.1 to 71.3 μ g/mL.",

keywords = "Cornus kousa, Cytotoxicity, Human colon carcinoma (HCT-116), Human hepatocellular carcinoma (HepG2), Lignan, MTT assay",

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T1 - Lignans from the fruits of Cornus kousa Burg. and their cytotoxic effects on human cancer cell lines

AU - Lee, Dae Young

AU - Song, Myoung Chong

AU - Yoo, Ki Hyun

AU - Bang, Myun Ho

AU - Chung, In Sik

AU - Kim, Sung Hoon

AU - Kim, Dae Keun

AU - Kwon, Byoung Mog

AU - Jeong, Tae Sook

AU - Park, Mi Hyun

AU - Baek, Nam In

PY - 2007/4/30

Y1 - 2007/4/30

N2 - The fruits of Cornus kousa Burg. were extracted with 80% aqueous MeOH, and the concentrated extract partitioned with EtOAc, n-BuOH and H2O. Six lignans were isolated from the EtOAc fraction through repeated silica gel, ODS and Sephadex LH-20 column chromatographies. From the physico-chemical data, including NMR, MS and IR, the chemical structures of the compounds were determined to be (+)-pinoresinol (1), (-)-balanophonin (2), (+)-laricresinol (3), erythro-guaiacylglycerol-β-coniferyl aldehyde ether (4), threo-guaiacylglycerol-β-coniferyl aldehyde ether (5) and dihydrodehydrodiconiferyl alcohol (6), which were isolated for the first time from this plant. Most of these compounds showed cytotoxicity against human colon carcinoma (HCT-116) and human hepatocellular carcinoma (HepG2) cell lines in vitro, with IC50 values ranging from 19.1 to 71.3 μ g/mL.

AB - The fruits of Cornus kousa Burg. were extracted with 80% aqueous MeOH, and the concentrated extract partitioned with EtOAc, n-BuOH and H2O. Six lignans were isolated from the EtOAc fraction through repeated silica gel, ODS and Sephadex LH-20 column chromatographies. From the physico-chemical data, including NMR, MS and IR, the chemical structures of the compounds were determined to be (+)-pinoresinol (1), (-)-balanophonin (2), (+)-laricresinol (3), erythro-guaiacylglycerol-β-coniferyl aldehyde ether (4), threo-guaiacylglycerol-β-coniferyl aldehyde ether (5) and dihydrodehydrodiconiferyl alcohol (6), which were isolated for the first time from this plant. Most of these compounds showed cytotoxicity against human colon carcinoma (HCT-116) and human hepatocellular carcinoma (HepG2) cell lines in vitro, with IC50 values ranging from 19.1 to 71.3 μ g/mL.

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KW - Cytotoxicity

KW - Human colon carcinoma (HCT-116)

KW - Human hepatocellular carcinoma (HepG2)

KW - Lignan

KW - MTT assay

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Lignans from the fruits of Cornus kousa Burg. and their cytotoxic effects on human cancer cell lines

Abstract

Keywords

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