LINCS L1000 dataset-based repositioning of CGP-60474 as a highly potent anti-endotoxemic agent

Immunology and Microbiology

• Mortality Rate 100%
• Antiinflammatory Activity 50%
• Macrophage 50%
• Macrophage Cell Line 50%
• Gene Expression 50%
• Tumor Necrosis Factor 50%
• Interleukin 6 50%
• Cycline 50%
• Innate Immune Cell 50%
• In Vitro 50%
• Kinase 50%
• Phosphotransferase 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Sepsis 100%
• Mortality Rate 40%
• Drug Development 20%
• Antiinflammatory Activity 20%
• Tumor Necrosis Factor 20%
• Syndrome 20%
• Cyclin Dependent Kinase 20%
• Virtual Screening 20%
• Inflammation 20%
• Interleukin 6 20%
• Lipopolysaccharide-Induced Endotoxemia 20%