Lipolytic effect of compounds isolated from leaves of mulberry (Morus alba L.) in 3T3-L1 adipocytes

Hong Xu Li; Eunji Jo; Chang Seon Myung; Young Ho Kim; Seo Young Yang

doi:10.1080/14786419.2017.1354190

Lipolytic effect of compounds isolated from leaves of mulberry (Morus alba L.) in 3T3-L1 adipocytes

Hong Xu Li, Eunji Jo, Chang Seon Myung, Young Ho Kim, Seo Young Yang

Department of Biology Education

Chungnam National University

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

In this study, 19 known compounds were isolated from mulberry (Morus alba L.) leaves. The lipid accumulation inhibitory activity of the isolated compounds was investigated. Compounds 4 and 12 showed good anti-adipogenic activity based on 3T3-L1 adipocytes with values of 36.6 ± 9.0 and 34.7 ± 4.0%, respectively. In addition, compounds 3, 6 and 15 showed significant inhibitory activity with values from 15.4 to 21.2% and compounds 2, 8–9 and 17–18 exhibited weak activity with values ranging from 2.1 to 10.7% at a concentration of 40.0 μM. These results show the potentiality that mulberry leaf is an excellent inhibitory phytochemical source against lipid accumulation.

Original language	English
Pages (from-to)	1963-1966
Number of pages	4
Journal	Natural Product Research
Volume	32
Issue number	16
DOIs	https://doi.org/10.1080/14786419.2017.1354190
State	Published - 18 Aug 2018

Keywords

Antiobesity
Lipid accumulation
Morus albaL
Mulberry leaf

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10.1080/14786419.2017.1354190

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title = "Lipolytic effect of compounds isolated from leaves of mulberry (Morus alba L.) in 3T3-L1 adipocytes",

abstract = "In this study, 19 known compounds were isolated from mulberry (Morus alba L.) leaves. The lipid accumulation inhibitory activity of the isolated compounds was investigated. Compounds 4 and 12 showed good anti-adipogenic activity based on 3T3-L1 adipocytes with values of 36.6 ± 9.0 and 34.7 ± 4.0%, respectively. In addition, compounds 3, 6 and 15 showed significant inhibitory activity with values from 15.4 to 21.2% and compounds 2, 8–9 and 17–18 exhibited weak activity with values ranging from 2.1 to 10.7% at a concentration of 40.0 μM. These results show the potentiality that mulberry leaf is an excellent inhibitory phytochemical source against lipid accumulation.",

keywords = "Antiobesity, Lipid accumulation, Morus albaL, Mulberry leaf",

author = "Li, {Hong Xu} and Eunji Jo and Myung, {Chang Seon} and Kim, {Young Ho} and Yang, {Seo Young}",

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AU - Li, Hong Xu

AU - Jo, Eunji

AU - Myung, Chang Seon

AU - Kim, Young Ho

AU - Yang, Seo Young

PY - 2018/8/18

Y1 - 2018/8/18

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AB - In this study, 19 known compounds were isolated from mulberry (Morus alba L.) leaves. The lipid accumulation inhibitory activity of the isolated compounds was investigated. Compounds 4 and 12 showed good anti-adipogenic activity based on 3T3-L1 adipocytes with values of 36.6 ± 9.0 and 34.7 ± 4.0%, respectively. In addition, compounds 3, 6 and 15 showed significant inhibitory activity with values from 15.4 to 21.2% and compounds 2, 8–9 and 17–18 exhibited weak activity with values ranging from 2.1 to 10.7% at a concentration of 40.0 μM. These results show the potentiality that mulberry leaf is an excellent inhibitory phytochemical source against lipid accumulation.

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KW - Lipid accumulation

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Lipolytic effect of compounds isolated from leaves of mulberry (Morus alba L.) in 3T3-L1 adipocytes

Abstract

Keywords

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