Longitudinal water proton relaxivity and in vivo T1 MR images of mixed Zn(II)/Gd(III) oxide nanoparticles

Tirusew Tegafaw; Bardul Alam Bony; Wenlong Xu; Hyunsil Cha; Yongmin Chang; Sang Hyup Lee; Kwon Seok Chae; Gang Ho Lee

doi:10.1166/jnn.2017.13052

Longitudinal water proton relaxivity and in vivo T₁ MR images of mixed Zn(II)/Gd(III) oxide nanoparticles

Tirusew Tegafaw, Bardul Alam Bony, Wenlong Xu, Hyunsil Cha, Yongmin Chang, Sang Hyup Lee, Kwon Seok Chae, Gang Ho Lee

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Mixed Zn(II)/Gd(III) oxide nanoparticles (∼8 mole%Zn) with d_avg of 2.1 nm were synthesized. The D-glucuronic acid coated Zn(II)/Gd(III) oxide nanoparticles showed a longitudinal water proton relaxivity (r₁) of 12.3 s^-1mM^-1 with r₂/r₁ = 1.1, corresponding to an ideal condition for T₁ MRI contrast agent. We attribute this to reduced magnetization of the mixed nanoparticles owing to non-magnetic Zn in the nanoparticles. Their effectiveness as a T₁ MRI contrast agent was confirmed by acquiring in vivo T₁ MR images of a mouse after intravenous injection.

Original language	English
Pages (from-to)	2423-2430
Number of pages	8
Journal	Journal of Nanoscience and Nanotechnology
Volume	17
Issue number	4
DOIs	https://doi.org/10.1166/jnn.2017.13052
State	Published - 2017

Keywords

Longitudinal water proton relaxivity
Mixed Zn(II)/Gd(III) oxide nanoparticle
T MR image

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10.1166/jnn.2017.13052

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title = "Longitudinal water proton relaxivity and in vivo T1 MR images of mixed Zn(II)/Gd(III) oxide nanoparticles",

abstract = "Mixed Zn(II)/Gd(III) oxide nanoparticles (∼8 mole%Zn) with davg of 2.1 nm were synthesized. The D-glucuronic acid coated Zn(II)/Gd(III) oxide nanoparticles showed a longitudinal water proton relaxivity (r1) of 12.3 s-1mM-1 with r2/r1 = 1.1, corresponding to an ideal condition for T1 MRI contrast agent. We attribute this to reduced magnetization of the mixed nanoparticles owing to non-magnetic Zn in the nanoparticles. Their effectiveness as a T1 MRI contrast agent was confirmed by acquiring in vivo T1 MR images of a mouse after intravenous injection.",

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author = "Tirusew Tegafaw and Bony, {Bardul Alam} and Wenlong Xu and Hyunsil Cha and Yongmin Chang and Lee, {Sang Hyup} and Chae, {Kwon Seok} and Lee, {Gang Ho}",

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doi = "10.1166/jnn.2017.13052",

language = "English",

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T1 - Longitudinal water proton relaxivity and in vivo T1 MR images of mixed Zn(II)/Gd(III) oxide nanoparticles

AU - Tegafaw, Tirusew

AU - Bony, Bardul Alam

AU - Xu, Wenlong

AU - Cha, Hyunsil

AU - Chang, Yongmin

AU - Lee, Sang Hyup

AU - Chae, Kwon Seok

AU - Lee, Gang Ho

PY - 2017

Y1 - 2017

N2 - Mixed Zn(II)/Gd(III) oxide nanoparticles (∼8 mole%Zn) with davg of 2.1 nm were synthesized. The D-glucuronic acid coated Zn(II)/Gd(III) oxide nanoparticles showed a longitudinal water proton relaxivity (r1) of 12.3 s-1mM-1 with r2/r1 = 1.1, corresponding to an ideal condition for T1 MRI contrast agent. We attribute this to reduced magnetization of the mixed nanoparticles owing to non-magnetic Zn in the nanoparticles. Their effectiveness as a T1 MRI contrast agent was confirmed by acquiring in vivo T1 MR images of a mouse after intravenous injection.

AB - Mixed Zn(II)/Gd(III) oxide nanoparticles (∼8 mole%Zn) with davg of 2.1 nm were synthesized. The D-glucuronic acid coated Zn(II)/Gd(III) oxide nanoparticles showed a longitudinal water proton relaxivity (r1) of 12.3 s-1mM-1 with r2/r1 = 1.1, corresponding to an ideal condition for T1 MRI contrast agent. We attribute this to reduced magnetization of the mixed nanoparticles owing to non-magnetic Zn in the nanoparticles. Their effectiveness as a T1 MRI contrast agent was confirmed by acquiring in vivo T1 MR images of a mouse after intravenous injection.

KW - Longitudinal water proton relaxivity

KW - Mixed Zn(II)/Gd(III) oxide nanoparticle

KW - T MR image

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DO - 10.1166/jnn.2017.13052

M3 - Article

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JO - Journal of Nanoscience and Nanotechnology

JF - Journal of Nanoscience and Nanotechnology

IS - 4

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Longitudinal water proton relaxivity and in vivo T₁ MR images of mixed Zn(II)/Gd(III) oxide nanoparticles

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