Loss of promyelocytic leukemia protein in human gastric cancers

Hee Eun Lee, Chang Do Jee, Min A. Kim, Hye Seung Lee, You Mie Lee, Byung Lan Lee, Woo Ho Kim

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

To clarify the clinical implications of promyelocytic leukemia (PML) expression in gastric carcinomas, the expression of PML was analyzed in large series of gastric carcinoma by immunohistochemistry, western blotting and reverse transcription-PCR. PML protein expression was reduced or abolished in gastric carcinomas (31.7 and 10.6%, respectively) by immunohistochemistry. PML protein loss was associated with more lymphatic invasion, higher pTNM stage, and worse patient survival. Only one gastric carcinoma cell line showed loss of PML, and the PML protein re-appeared after the treatment of proteasome inhibitor in this cell line. We conclude that PML protein loss occurs in a minority of gastric carcinomas during carcinogenesis and progression, and suggest the proteasome-dependent pathway as a mechanism of PML protein loss.

Original languageEnglish
Pages (from-to)103-109
Number of pages7
JournalCancer Letters
Volume247
Issue number1-2
DOIs
StatePublished - 8 Mar 2007

Keywords

  • Gastric cancers
  • Immunohistochemistry
  • PML protein
  • Proteasome inhibitor
  • Survival analysis
  • Tissue array analysis

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