Low trans structured fat from flaxseed oil improves plasma and hepatic lipid metabolism in apo E-/- mice

Yun Young Cho; Eun Young Kwon; Hye Jin Kim; Yong Bok Park; Ki Teak Lee; Tae Sun Park; Myung Sook Choi

doi:10.1016/j.fct.2009.04.001

Low trans structured fat from flaxseed oil improves plasma and hepatic lipid metabolism in apo E^-/- mice

Yun Young Cho, Eun Young Kwon, Hye Jin Kim, Yong Bok Park, Ki Teak Lee, Tae Sun Park, Myung Sook Choi

Department of Food Science and Nutrition

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The objective of this study was to explicate the effects of feeding low trans structured fat from flaxseed oil (LF) on plasma and hepatic lipid metabolism involved in apo E^-/- mice. The animals were fed a commercial shortening (CS), commercial low trans fat (CL) and LF diet based on AIN-76 diet (10% fat) for 12 weeks. LF supplementation exerted a significant suppression in hepatic lipid accumulation with the concomitant decrease in liver weight. The LF significantly lowered plasma total cholesterol and free fatty acid whereas it significantly increased HDL-C concentration and the HDL-C/total-C ratio compared to the CS group. Reduction of hepatic lipid levels in the LF group was related with the suppression of hepatic enzyme activities for fatty acid and triglyceride synthesis, and cholesterol regulating enzyme activity compared to the CS and CL groups. Accordingly, low trans structured fat from flaxseed oil is highly effective for improving hyperlipidemia and hepatic lipid accumulation in apo E^-/- mice.

Original language	English
Pages (from-to)	1550-1555
Number of pages	6
Journal	Food and Chemical Toxicology
Volume	47
Issue number	7
DOIs	https://doi.org/10.1016/j.fct.2009.04.001
State	Published - Jul 2009

Keywords

Apo E mice
Flaxseed oil
Hyperlipidemia
n - 3 fatty acid
Trans fatty acid

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10.1016/j.fct.2009.04.001

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title = "Low trans structured fat from flaxseed oil improves plasma and hepatic lipid metabolism in apo E-/- mice",

abstract = "The objective of this study was to explicate the effects of feeding low trans structured fat from flaxseed oil (LF) on plasma and hepatic lipid metabolism involved in apo E-/- mice. The animals were fed a commercial shortening (CS), commercial low trans fat (CL) and LF diet based on AIN-76 diet (10% fat) for 12 weeks. LF supplementation exerted a significant suppression in hepatic lipid accumulation with the concomitant decrease in liver weight. The LF significantly lowered plasma total cholesterol and free fatty acid whereas it significantly increased HDL-C concentration and the HDL-C/total-C ratio compared to the CS group. Reduction of hepatic lipid levels in the LF group was related with the suppression of hepatic enzyme activities for fatty acid and triglyceride synthesis, and cholesterol regulating enzyme activity compared to the CS and CL groups. Accordingly, low trans structured fat from flaxseed oil is highly effective for improving hyperlipidemia and hepatic lipid accumulation in apo E-/- mice.",

keywords = "Apo E mice, Flaxseed oil, Hyperlipidemia, n - 3 fatty acid, Trans fatty acid",

author = "Cho, {Yun Young} and Kwon, {Eun Young} and Kim, {Hye Jin} and Park, {Yong Bok} and Lee, {Ki Teak} and Park, {Tae Sun} and Choi, {Myung Sook}",

year = "2009",

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doi = "10.1016/j.fct.2009.04.001",

language = "English",

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T1 - Low trans structured fat from flaxseed oil improves plasma and hepatic lipid metabolism in apo E-/- mice

AU - Cho, Yun Young

AU - Kwon, Eun Young

AU - Kim, Hye Jin

AU - Park, Yong Bok

AU - Lee, Ki Teak

AU - Park, Tae Sun

AU - Choi, Myung Sook

PY - 2009/7

Y1 - 2009/7

N2 - The objective of this study was to explicate the effects of feeding low trans structured fat from flaxseed oil (LF) on plasma and hepatic lipid metabolism involved in apo E-/- mice. The animals were fed a commercial shortening (CS), commercial low trans fat (CL) and LF diet based on AIN-76 diet (10% fat) for 12 weeks. LF supplementation exerted a significant suppression in hepatic lipid accumulation with the concomitant decrease in liver weight. The LF significantly lowered plasma total cholesterol and free fatty acid whereas it significantly increased HDL-C concentration and the HDL-C/total-C ratio compared to the CS group. Reduction of hepatic lipid levels in the LF group was related with the suppression of hepatic enzyme activities for fatty acid and triglyceride synthesis, and cholesterol regulating enzyme activity compared to the CS and CL groups. Accordingly, low trans structured fat from flaxseed oil is highly effective for improving hyperlipidemia and hepatic lipid accumulation in apo E-/- mice.

AB - The objective of this study was to explicate the effects of feeding low trans structured fat from flaxseed oil (LF) on plasma and hepatic lipid metabolism involved in apo E-/- mice. The animals were fed a commercial shortening (CS), commercial low trans fat (CL) and LF diet based on AIN-76 diet (10% fat) for 12 weeks. LF supplementation exerted a significant suppression in hepatic lipid accumulation with the concomitant decrease in liver weight. The LF significantly lowered plasma total cholesterol and free fatty acid whereas it significantly increased HDL-C concentration and the HDL-C/total-C ratio compared to the CS group. Reduction of hepatic lipid levels in the LF group was related with the suppression of hepatic enzyme activities for fatty acid and triglyceride synthesis, and cholesterol regulating enzyme activity compared to the CS and CL groups. Accordingly, low trans structured fat from flaxseed oil is highly effective for improving hyperlipidemia and hepatic lipid accumulation in apo E-/- mice.

KW - Apo E mice

KW - Flaxseed oil

KW - Hyperlipidemia

KW - n - 3 fatty acid

KW - Trans fatty acid

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SN - 0278-6915

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SP - 1550

EP - 1555

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

IS - 7

ER -

Low trans structured fat from flaxseed oil improves plasma and hepatic lipid metabolism in apo E^-/- mice

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