Magnetic and MR relaxation properties of avidin-biotin conjugated superparamagnetic nanoparticles

Ji Ae Park; Jae Jun Lee; In Sung Kim; Bo Hyung Park; Gang Ho Lee; Tae Jeong Kim; Hyeong Cheol Ri; Hye Jung Kim; Yongmin Chang

doi:10.1016/j.colsurfa.2007.04.172

Magnetic and MR relaxation properties of avidin-biotin conjugated superparamagnetic nanoparticles

Ji Ae Park, Jae Jun Lee, In Sung Kim, Bo Hyung Park, Gang Ho Lee, Tae Jeong Kim, Hyeong Cheol Ri, Hye Jung Kim, Yongmin Chang

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Recently, much attention has been given to the development of novel biomedical imaging applications of bio-functionalized nanoparticles which possess optical, magnetic, and opto-magnetic properties for molecular and cellular events. For bioconjugation the avidin-biotin system is often introduced as a linker between nanoparticles and biological markers. In case of magnetic resonance imaging (MRI), it is important to investigate the magnetic property of avidin-biotin linker system in addition to superparamagnetic nanoparticle itself. In this study, we investigate the alteration of magnetic properties of magnetic nanoparticle by avidin-biotin system and the change of the MR relaxation property by synthesizing and characterizing a polycaprolactone coated iron oxide nanoparticles (PCLNP), avidin conjugated PCLNP (A-PCLNP) and avidin-biotin conjugated PCLNP (A-B-PCLNP). Our results demonstrated that diamagnetic property of the avidin-biotin system reduced the total magnetization of avidin-biotin conjugated superparamagnetic nanoparticle and thus reduced the efficiency as an MR T2 relaxation agent.

Original language	English
Pages (from-to)	288-291
Number of pages	4
Journal	Colloids and Surfaces A: Physicochemical and Engineering Aspects
Volume	313-314
DOIs	https://doi.org/10.1016/j.colsurfa.2007.04.172
State	Published - 1 Feb 2008

Keywords

Avidin-biotin conjugated superparamagnetic nanoparticle
MR T2 relaxation agent
Polycaprolactone coated iron oxide nanoparticles (PCLNP)

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10.1016/j.colsurfa.2007.04.172

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title = "Magnetic and MR relaxation properties of avidin-biotin conjugated superparamagnetic nanoparticles",

abstract = "Recently, much attention has been given to the development of novel biomedical imaging applications of bio-functionalized nanoparticles which possess optical, magnetic, and opto-magnetic properties for molecular and cellular events. For bioconjugation the avidin-biotin system is often introduced as a linker between nanoparticles and biological markers. In case of magnetic resonance imaging (MRI), it is important to investigate the magnetic property of avidin-biotin linker system in addition to superparamagnetic nanoparticle itself. In this study, we investigate the alteration of magnetic properties of magnetic nanoparticle by avidin-biotin system and the change of the MR relaxation property by synthesizing and characterizing a polycaprolactone coated iron oxide nanoparticles (PCLNP), avidin conjugated PCLNP (A-PCLNP) and avidin-biotin conjugated PCLNP (A-B-PCLNP). Our results demonstrated that diamagnetic property of the avidin-biotin system reduced the total magnetization of avidin-biotin conjugated superparamagnetic nanoparticle and thus reduced the efficiency as an MR T2 relaxation agent.",

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doi = "10.1016/j.colsurfa.2007.04.172",

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AU - Park, Ji Ae

AU - Lee, Jae Jun

AU - Kim, In Sung

AU - Park, Bo Hyung

AU - Lee, Gang Ho

AU - Kim, Tae Jeong

AU - Ri, Hyeong Cheol

AU - Kim, Hye Jung

AU - Chang, Yongmin

PY - 2008/2/1

Y1 - 2008/2/1

N2 - Recently, much attention has been given to the development of novel biomedical imaging applications of bio-functionalized nanoparticles which possess optical, magnetic, and opto-magnetic properties for molecular and cellular events. For bioconjugation the avidin-biotin system is often introduced as a linker between nanoparticles and biological markers. In case of magnetic resonance imaging (MRI), it is important to investigate the magnetic property of avidin-biotin linker system in addition to superparamagnetic nanoparticle itself. In this study, we investigate the alteration of magnetic properties of magnetic nanoparticle by avidin-biotin system and the change of the MR relaxation property by synthesizing and characterizing a polycaprolactone coated iron oxide nanoparticles (PCLNP), avidin conjugated PCLNP (A-PCLNP) and avidin-biotin conjugated PCLNP (A-B-PCLNP). Our results demonstrated that diamagnetic property of the avidin-biotin system reduced the total magnetization of avidin-biotin conjugated superparamagnetic nanoparticle and thus reduced the efficiency as an MR T2 relaxation agent.

AB - Recently, much attention has been given to the development of novel biomedical imaging applications of bio-functionalized nanoparticles which possess optical, magnetic, and opto-magnetic properties for molecular and cellular events. For bioconjugation the avidin-biotin system is often introduced as a linker between nanoparticles and biological markers. In case of magnetic resonance imaging (MRI), it is important to investigate the magnetic property of avidin-biotin linker system in addition to superparamagnetic nanoparticle itself. In this study, we investigate the alteration of magnetic properties of magnetic nanoparticle by avidin-biotin system and the change of the MR relaxation property by synthesizing and characterizing a polycaprolactone coated iron oxide nanoparticles (PCLNP), avidin conjugated PCLNP (A-PCLNP) and avidin-biotin conjugated PCLNP (A-B-PCLNP). Our results demonstrated that diamagnetic property of the avidin-biotin system reduced the total magnetization of avidin-biotin conjugated superparamagnetic nanoparticle and thus reduced the efficiency as an MR T2 relaxation agent.

KW - Avidin-biotin conjugated superparamagnetic nanoparticle

KW - MR T2 relaxation agent

KW - Polycaprolactone coated iron oxide nanoparticles (PCLNP)

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JO - Colloids and Surfaces A: Physicochemical and Engineering Aspects

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ER -

Magnetic and MR relaxation properties of avidin-biotin conjugated superparamagnetic nanoparticles

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