Magnetic properties, water proton relaxivities, and in-vivo MR images of paramagnetic nanoparticles

Gang Ho Lee; Yongmin Chang

doi:10.3938/jkps.67.44

Magnetic properties, water proton relaxivities, and in-vivo MR images of paramagnetic nanoparticles

Gang Ho Lee, Yongmin Chang

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

In this mini review, magnetic resonance imaging (MRI) contrast agents based on lanthanideoxide (Ln₂O₃) nanoparticles are described. Ln₂O₃ (Ln = Gd, Dy, Ho, and Er) nanoparticles are paramagnetic, but show appreciable magnetic moments at room temperature and even at ultrasmall particle diameters. Among Ln₂O₃ nanoparticles, Gd2O3 nanoparticles show larger longitudinal water proton relaxivity (r₁) values than Gd-chelates because of the large amount of Gd in the nanoparticle, and the other Ln₂O₃ nanoparticles (Ln = Dy, Ho, and Er) show appreciable transverse water proton relaxivity (r₂) values. Therefore, Gd₂O₃ nanoparticles are potential T₁ MRI contrast agents while the other Ln₂O₃ nanoparticles are potential T₂ MRI contrast agents at high MR fields.

Original language	English
Pages (from-to)	44-51
Number of pages	8
Journal	Journal of the Korean Physical Society
Volume	67
Issue number	1
DOIs	https://doi.org/10.3938/jkps.67.44
State	Published - 31 Jul 2015

Keywords

Contrast agent
MRI
Paramagnetic nanoparticle

Access to Document

10.3938/jkps.67.44

Cite this

@article{d4c0e543f3db414b930e6dc66525c412,

title = "Magnetic properties, water proton relaxivities, and in-vivo MR images of paramagnetic nanoparticles",

abstract = "In this mini review, magnetic resonance imaging (MRI) contrast agents based on lanthanideoxide (Ln2O3) nanoparticles are described. Ln2O3 (Ln = Gd, Dy, Ho, and Er) nanoparticles are paramagnetic, but show appreciable magnetic moments at room temperature and even at ultrasmall particle diameters. Among Ln2O3 nanoparticles, Gd2O3 nanoparticles show larger longitudinal water proton relaxivity (r1) values than Gd-chelates because of the large amount of Gd in the nanoparticle, and the other Ln2O3 nanoparticles (Ln = Dy, Ho, and Er) show appreciable transverse water proton relaxivity (r2) values. Therefore, Gd2O3 nanoparticles are potential T1 MRI contrast agents while the other Ln2O3 nanoparticles are potential T2 MRI contrast agents at high MR fields.",

keywords = "Contrast agent, MRI, Paramagnetic nanoparticle",

author = "Lee, {Gang Ho} and Yongmin Chang",

note = "Publisher Copyright: {\textcopyright} 2015, The Korean Physical Society.",

year = "2015",

month = jul,

day = "31",

doi = "10.3938/jkps.67.44",

language = "English",

volume = "67",

pages = "44--51",

journal = "Journal of the Korean Physical Society",

issn = "0374-4884",

publisher = "Korean Physical Society",

number = "1",

}

TY - JOUR

T1 - Magnetic properties, water proton relaxivities, and in-vivo MR images of paramagnetic nanoparticles

AU - Lee, Gang Ho

AU - Chang, Yongmin

PY - 2015/7/31

Y1 - 2015/7/31

N2 - In this mini review, magnetic resonance imaging (MRI) contrast agents based on lanthanideoxide (Ln2O3) nanoparticles are described. Ln2O3 (Ln = Gd, Dy, Ho, and Er) nanoparticles are paramagnetic, but show appreciable magnetic moments at room temperature and even at ultrasmall particle diameters. Among Ln2O3 nanoparticles, Gd2O3 nanoparticles show larger longitudinal water proton relaxivity (r1) values than Gd-chelates because of the large amount of Gd in the nanoparticle, and the other Ln2O3 nanoparticles (Ln = Dy, Ho, and Er) show appreciable transverse water proton relaxivity (r2) values. Therefore, Gd2O3 nanoparticles are potential T1 MRI contrast agents while the other Ln2O3 nanoparticles are potential T2 MRI contrast agents at high MR fields.

AB - In this mini review, magnetic resonance imaging (MRI) contrast agents based on lanthanideoxide (Ln2O3) nanoparticles are described. Ln2O3 (Ln = Gd, Dy, Ho, and Er) nanoparticles are paramagnetic, but show appreciable magnetic moments at room temperature and even at ultrasmall particle diameters. Among Ln2O3 nanoparticles, Gd2O3 nanoparticles show larger longitudinal water proton relaxivity (r1) values than Gd-chelates because of the large amount of Gd in the nanoparticle, and the other Ln2O3 nanoparticles (Ln = Dy, Ho, and Er) show appreciable transverse water proton relaxivity (r2) values. Therefore, Gd2O3 nanoparticles are potential T1 MRI contrast agents while the other Ln2O3 nanoparticles are potential T2 MRI contrast agents at high MR fields.

KW - Contrast agent

KW - MRI

KW - Paramagnetic nanoparticle

UR - http://www.scopus.com/inward/record.url?scp=84938398909&partnerID=8YFLogxK

U2 - 10.3938/jkps.67.44

DO - 10.3938/jkps.67.44

M3 - Article

AN - SCOPUS:84938398909

SN - 0374-4884

VL - 67

SP - 44

EP - 51

JO - Journal of the Korean Physical Society

JF - Journal of the Korean Physical Society

IS - 1

ER -

Magnetic properties, water proton relaxivities, and in-vivo MR images of paramagnetic nanoparticles

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this