Maturation of bone marrow-derived dendritic cells by a novel β-glucan purified from Paenibacillus polymyxa JB115

Eun Ju Ko; Yun Young Byon; Youngheun Jee; Taekyun Shin; Seung Chun Park; Tae Wook Hahn; Hong Gu Joo

doi:10.4142/jvs.2011.12.2.187

Maturation of bone marrow-derived dendritic cells by a novel β-glucan purified from Paenibacillus polymyxa JB115

Eun Ju Ko, Yun Young Byon, Youngheun Jee, Taekyun Shin, Seung Chun Park, Tae Wook Hahn, Hong Gu Joo

Department of Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

We investigated the immunostimulatory effects of a novel β-glucan purified from Paenibacillus (P.) polymyxa JB115 on bone marrow-derived dendritic cells (DCs), a type of potent antigen-presenting cells. β-glucan isolated from P. polymyxa JB115 enhanced the viability and induced the maturation of DCs. β-glucan markedly increased the cytokine production of DCs and surface expression of DC markers. In addition, DCs treated with β-glucan showed a higher capacity to stimulate allogeneic spleen cell proliferation compared to those treated with medium alone. These results demonstrate the effect of β-glucan on DC maturation and may increase the use of β-glucan.

Original language	English
Pages (from-to)	187-190
Number of pages	4
Journal	Journal of Veterinary Science
Volume	12
Issue number	2
DOIs	https://doi.org/10.4142/jvs.2011.12.2.187
State	Published - 2011

Keywords

β-glucan
Dendritic cells
JB115
Maturation
Paenibacillus polymyxa

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10.4142/jvs.2011.12.2.187

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title = "Maturation of bone marrow-derived dendritic cells by a novel β-glucan purified from Paenibacillus polymyxa JB115",

abstract = "We investigated the immunostimulatory effects of a novel β-glucan purified from Paenibacillus (P.) polymyxa JB115 on bone marrow-derived dendritic cells (DCs), a type of potent antigen-presenting cells. β-glucan isolated from P. polymyxa JB115 enhanced the viability and induced the maturation of DCs. β-glucan markedly increased the cytokine production of DCs and surface expression of DC markers. In addition, DCs treated with β-glucan showed a higher capacity to stimulate allogeneic spleen cell proliferation compared to those treated with medium alone. These results demonstrate the effect of β-glucan on DC maturation and may increase the use of β-glucan.",

keywords = "β-glucan, Dendritic cells, JB115, Maturation, Paenibacillus polymyxa",

author = "Ko, {Eun Ju} and Byon, {Yun Young} and Youngheun Jee and Taekyun Shin and Park, {Seung Chun} and Hahn, {Tae Wook} and Joo, {Hong Gu}",

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AU - Byon, Yun Young

AU - Jee, Youngheun

AU - Shin, Taekyun

AU - Park, Seung Chun

AU - Hahn, Tae Wook

AU - Joo, Hong Gu

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AB - We investigated the immunostimulatory effects of a novel β-glucan purified from Paenibacillus (P.) polymyxa JB115 on bone marrow-derived dendritic cells (DCs), a type of potent antigen-presenting cells. β-glucan isolated from P. polymyxa JB115 enhanced the viability and induced the maturation of DCs. β-glucan markedly increased the cytokine production of DCs and surface expression of DC markers. In addition, DCs treated with β-glucan showed a higher capacity to stimulate allogeneic spleen cell proliferation compared to those treated with medium alone. These results demonstrate the effect of β-glucan on DC maturation and may increase the use of β-glucan.

KW - β-glucan

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Maturation of bone marrow-derived dendritic cells by a novel β-glucan purified from Paenibacillus polymyxa JB115

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