Abstract
We investigated the immunostimulatory effects of a novel β-glucan purified from Paenibacillus (P.) polymyxa JB115 on bone marrow-derived dendritic cells (DCs), a type of potent antigen-presenting cells. β-glucan isolated from P. polymyxa JB115 enhanced the viability and induced the maturation of DCs. β-glucan markedly increased the cytokine production of DCs and surface expression of DC markers. In addition, DCs treated with β-glucan showed a higher capacity to stimulate allogeneic spleen cell proliferation compared to those treated with medium alone. These results demonstrate the effect of β-glucan on DC maturation and may increase the use of β-glucan.
| Original language | English |
|---|---|
| Pages (from-to) | 187-190 |
| Number of pages | 4 |
| Journal | Journal of Veterinary Science |
| Volume | 12 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2011 |
Keywords
- β-glucan
- Dendritic cells
- JB115
- Maturation
- Paenibacillus polymyxa
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