MC3T3-E1 cell differentiation and in vivo bone formation induced by phosphoserine

Jin Woo Park; Youn Jeong Kim; Je Hee Jang; Chang Hyeon An

doi:10.1007/s10529-011-0565-0

MC3T3-E1 cell differentiation and in vivo bone formation induced by phosphoserine

Jin Woo Park
, Youn Jeong Kim
, Je Hee Jang
, Chang Hyeon An

Department of Dentistry

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Bone formation induced by phosphoserine was investigated in vitro and in vivo using MC3T3-E1 cells and a rabbit calvarial osseous defect model. MC3T3-E1 cells supplemented by phosphoserine displayed two-fold higher alkaline phosphatase activity and mineralization nodule formation, and calvarial defects treated with phosphoserine showed statistically significant new bone formation compared with the control (P < 0.05).

Original language	English
Pages (from-to)	1473-1480
Number of pages	8
Journal	Biotechnology Letters
Volume	33
Issue number	7
DOIs	https://doi.org/10.1007/s10529-011-0565-0
State	Published - Jul 2011

Keywords

Bone formation
MC3T3-E1 cell
Osteoblast differentiation
Phosphoserine

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10.1007/s10529-011-0565-0

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title = "MC3T3-E1 cell differentiation and in vivo bone formation induced by phosphoserine",

abstract = "Bone formation induced by phosphoserine was investigated in vitro and in vivo using MC3T3-E1 cells and a rabbit calvarial osseous defect model. MC3T3-E1 cells supplemented by phosphoserine displayed two-fold higher alkaline phosphatase activity and mineralization nodule formation, and calvarial defects treated with phosphoserine showed statistically significant new bone formation compared with the control (P < 0.05).",

keywords = "Bone formation, MC3T3-E1 cell, Osteoblast differentiation, Phosphoserine",

author = "Park, \{Jin Woo\} and Kim, \{Youn Jeong\} and Jang, \{Je Hee\} and An, \{Chang Hyeon\}",

year = "2011",

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language = "English",

volume = "33",

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journal = "Biotechnology Letters",

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AU - Park, Jin Woo

AU - Kim, Youn Jeong

AU - Jang, Je Hee

AU - An, Chang Hyeon

PY - 2011/7

Y1 - 2011/7

N2 - Bone formation induced by phosphoserine was investigated in vitro and in vivo using MC3T3-E1 cells and a rabbit calvarial osseous defect model. MC3T3-E1 cells supplemented by phosphoserine displayed two-fold higher alkaline phosphatase activity and mineralization nodule formation, and calvarial defects treated with phosphoserine showed statistically significant new bone formation compared with the control (P < 0.05).

AB - Bone formation induced by phosphoserine was investigated in vitro and in vivo using MC3T3-E1 cells and a rabbit calvarial osseous defect model. MC3T3-E1 cells supplemented by phosphoserine displayed two-fold higher alkaline phosphatase activity and mineralization nodule formation, and calvarial defects treated with phosphoserine showed statistically significant new bone formation compared with the control (P < 0.05).

KW - Bone formation

KW - MC3T3-E1 cell

KW - Osteoblast differentiation

KW - Phosphoserine

UR - https://www.scopus.com/pages/publications/79958769307

U2 - 10.1007/s10529-011-0565-0

DO - 10.1007/s10529-011-0565-0

M3 - Article

C2 - 21344205

AN - SCOPUS:79958769307

SN - 0141-5492

VL - 33

SP - 1473

EP - 1480

JO - Biotechnology Letters

JF - Biotechnology Letters

IS - 7

ER -

MC3T3-E1 cell differentiation and in vivo bone formation induced by phosphoserine

Abstract

Keywords

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