Medication Adherence of Statin Users after Acute Ischemic Stroke

Pil Wook Chung; Byung Woo Yoon; Yeong Bae Lee; Byoung Soo Shin; Hahn Young Kim; Jae Hyeon Park; Byung Kun Kim; Bong Goo Yoo; Won Chul Shin; Eung Gyu Kim; Jin Kuk Do; Kyung Pil Park; Yohan Jung; Woo Keun Seo; Moon Ku Han; Jei Kim; Yongduk Kim; Oh Young Bang; Yang Ha Hwang; Jin Hye Cha; Young Joo Kim

doi:10.1159/000493530

Medication Adherence of Statin Users after Acute Ischemic Stroke

Pil Wook Chung, Byung Woo Yoon, Yeong Bae Lee, Byoung Soo Shin, Hahn Young Kim, Jae Hyeon Park, Byung Kun Kim, Bong Goo Yoo, Won Chul Shin, Eung Gyu Kim, Jin Kuk Do, Kyung Pil Park, Yohan Jung, Woo Keun Seo, Moon Ku Han, Jei Kim, Yongduk Kim, Oh Young Bang, Yang Ha Hwang, Jin Hye ChaYoung Joo Kim

Department of Medicine

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Although statins are established therapy for the secondary prevention of ischemic stroke, factors associated with adherence to statin treatment following ischemic stroke are not well known. To address this, we assessed the 6-month statin adherence using 8-item Morisky Medication Adherence Scale-8 in patients with acute ischemic stroke. Of 991 patients, 65.6% were adherent to statin at 6-month after discharge. Multiple logistic regression analysis showed that patients' awareness of hyperlipidemia (OR 1.62; 95% CI 1.07-2.43), large artery stroke subtype (versus non-large artery stroke, OR 1.79; 95% CI 1.19-2.68), and alcohol drinking habits (OR 1.64; 95% CI 1.06-2.53) were positively associated, while high statin dose (versus low dose, OR 0.6; 95% CI 0.40-0.90) and higher daily number of medication pills (OR 0.93; 95% CI 0.88-0.97) were found to have a negative association with self-reported good adherence to statin medication after acute ischemic stroke. However, stroke severity and diagnosis of hyperlipidemia were not associated with adherence. These results suggest that educational and motivational interventions may enhance statin adherence because modifiable factors were associated with statin adherence.

Original language	English
Pages (from-to)	73-77
Number of pages	5
Journal	European Neurology
Volume	80
Issue number	1-2
DOIs	https://doi.org/10.1159/000493530
State	Published - 1 Nov 2018

Keywords

Acute ischemic stroke
Patient-reported outcomes
Quality of life
Statin adherence

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Chung, P. W., Yoon, B. W., Lee, Y. B., Shin, B. S., Kim, H. Y., Park, J. H., Kim, B. K., Yoo, B. G., Shin, W. C., Kim, E. G., Do, J. K., Park, K. P., Jung, Y., Seo, W. K., Han, M. K., Kim, J., Kim, Y., Bang, O. Y., Hwang, Y. H., ... Kim, Y. J. (2018). Medication Adherence of Statin Users after Acute Ischemic Stroke. European Neurology, 80(1-2), 73-77. https://doi.org/10.1159/000493530

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title = "Medication Adherence of Statin Users after Acute Ischemic Stroke",

abstract = "Although statins are established therapy for the secondary prevention of ischemic stroke, factors associated with adherence to statin treatment following ischemic stroke are not well known. To address this, we assessed the 6-month statin adherence using 8-item Morisky Medication Adherence Scale-8 in patients with acute ischemic stroke. Of 991 patients, 65.6% were adherent to statin at 6-month after discharge. Multiple logistic regression analysis showed that patients' awareness of hyperlipidemia (OR 1.62; 95% CI 1.07-2.43), large artery stroke subtype (versus non-large artery stroke, OR 1.79; 95% CI 1.19-2.68), and alcohol drinking habits (OR 1.64; 95% CI 1.06-2.53) were positively associated, while high statin dose (versus low dose, OR 0.6; 95% CI 0.40-0.90) and higher daily number of medication pills (OR 0.93; 95% CI 0.88-0.97) were found to have a negative association with self-reported good adherence to statin medication after acute ischemic stroke. However, stroke severity and diagnosis of hyperlipidemia were not associated with adherence. These results suggest that educational and motivational interventions may enhance statin adherence because modifiable factors were associated with statin adherence.",

keywords = "Acute ischemic stroke, Patient-reported outcomes, Quality of life, Statin adherence",

author = "Chung, {Pil Wook} and Yoon, {Byung Woo} and Lee, {Yeong Bae} and Shin, {Byoung Soo} and Kim, {Hahn Young} and Park, {Jae Hyeon} and Kim, {Byung Kun} and Yoo, {Bong Goo} and Shin, {Won Chul} and Kim, {Eung Gyu} and Do, {Jin Kuk} and Park, {Kyung Pil} and Yohan Jung and Seo, {Woo Keun} and Han, {Moon Ku} and Jei Kim and Yongduk Kim and Bang, {Oh Young} and Hwang, {Yang Ha} and Cha, {Jin Hye} and Kim, {Young Joo}",

note = "Publisher Copyright: {\textcopyright} 2018 2018 S. Karger AG, Basel.",

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doi = "10.1159/000493530",

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T1 - Medication Adherence of Statin Users after Acute Ischemic Stroke

AU - Chung, Pil Wook

AU - Yoon, Byung Woo

AU - Lee, Yeong Bae

AU - Shin, Byoung Soo

AU - Kim, Hahn Young

AU - Park, Jae Hyeon

AU - Kim, Byung Kun

AU - Yoo, Bong Goo

AU - Shin, Won Chul

AU - Kim, Eung Gyu

AU - Do, Jin Kuk

AU - Park, Kyung Pil

AU - Jung, Yohan

AU - Seo, Woo Keun

AU - Han, Moon Ku

AU - Kim, Jei

AU - Kim, Yongduk

AU - Bang, Oh Young

AU - Hwang, Yang Ha

AU - Cha, Jin Hye

AU - Kim, Young Joo

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Although statins are established therapy for the secondary prevention of ischemic stroke, factors associated with adherence to statin treatment following ischemic stroke are not well known. To address this, we assessed the 6-month statin adherence using 8-item Morisky Medication Adherence Scale-8 in patients with acute ischemic stroke. Of 991 patients, 65.6% were adherent to statin at 6-month after discharge. Multiple logistic regression analysis showed that patients' awareness of hyperlipidemia (OR 1.62; 95% CI 1.07-2.43), large artery stroke subtype (versus non-large artery stroke, OR 1.79; 95% CI 1.19-2.68), and alcohol drinking habits (OR 1.64; 95% CI 1.06-2.53) were positively associated, while high statin dose (versus low dose, OR 0.6; 95% CI 0.40-0.90) and higher daily number of medication pills (OR 0.93; 95% CI 0.88-0.97) were found to have a negative association with self-reported good adherence to statin medication after acute ischemic stroke. However, stroke severity and diagnosis of hyperlipidemia were not associated with adherence. These results suggest that educational and motivational interventions may enhance statin adherence because modifiable factors were associated with statin adherence.

AB - Although statins are established therapy for the secondary prevention of ischemic stroke, factors associated with adherence to statin treatment following ischemic stroke are not well known. To address this, we assessed the 6-month statin adherence using 8-item Morisky Medication Adherence Scale-8 in patients with acute ischemic stroke. Of 991 patients, 65.6% were adherent to statin at 6-month after discharge. Multiple logistic regression analysis showed that patients' awareness of hyperlipidemia (OR 1.62; 95% CI 1.07-2.43), large artery stroke subtype (versus non-large artery stroke, OR 1.79; 95% CI 1.19-2.68), and alcohol drinking habits (OR 1.64; 95% CI 1.06-2.53) were positively associated, while high statin dose (versus low dose, OR 0.6; 95% CI 0.40-0.90) and higher daily number of medication pills (OR 0.93; 95% CI 0.88-0.97) were found to have a negative association with self-reported good adherence to statin medication after acute ischemic stroke. However, stroke severity and diagnosis of hyperlipidemia were not associated with adherence. These results suggest that educational and motivational interventions may enhance statin adherence because modifiable factors were associated with statin adherence.

KW - Acute ischemic stroke

KW - Patient-reported outcomes

KW - Quality of life

KW - Statin adherence

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DO - 10.1159/000493530

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SP - 73

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JO - European Neurology

JF - European Neurology

IS - 1-2

ER -

Medication Adherence of Statin Users after Acute Ischemic Stroke

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Keywords

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