Melanin biosynthesis inhibition effects of ginsenoside Rb2 isolated from panax ginseng berry

Dae Young Lee; Yong Tae Jeong; Sang Chul Jeong; Mi Kyoung Lee; Jin Woo Min; Jae Won Lee; Geum Soog Kim; Seung Eun Lee; Young Sup Ahn; Hee Cheol Kang; Jin Hee Kim

doi:10.4014/jmb.1505.05069

Melanin biosynthesis inhibition effects of ginsenoside Rb2 isolated from panax ginseng berry

Dae Young Lee, Yong Tae Jeong, Sang Chul Jeong, Mi Kyoung Lee, Jin Woo Min, Jae Won Lee, Geum Soog Kim, Seung Eun Lee, Young Sup Ahn, Hee Cheol Kang, Jin Hee Kim

School of Life Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Ginsenoside Rb2 (Gin-Rb2) was purified from the fruit extract of Panax ginseng. Its chemical structure was measured by spectroscopic analysis, including HR-FAB-MS, ¹H-NMR, and IR spectroscopy. Gin-Rb2 decreased potent melanogenesis in melan-a cells, with 23.4% at 80 μM without cytotoxicity. Gin-Rb2 also decreased tyrosinase and MITF protein expression in melan-a cells. Furthermore, Gin-Rb2 presented inhibition of the body pigmentation in the zebrafish in vivo system and reduced melanin contents and tyrosinase activity. These results show that Gin-Rb2 isolated from P. ginseng may be an effective skin-whitening agent via the in vitro and in vivo systems.

Original language	English
Pages (from-to)	2011-2015
Number of pages	5
Journal	Journal of Microbiology and Biotechnology
Volume	25
Issue number	12
DOIs	https://doi.org/10.4014/jmb.1505.05069
State	Published - 6 Oct 2015

Keywords

Ginsenoside Rb2
Melan-a cell
Melanin biosynthesis
Panax ginseng
Zebrafish

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title = "Melanin biosynthesis inhibition effects of ginsenoside Rb2 isolated from panax ginseng berry",

abstract = "Ginsenoside Rb2 (Gin-Rb2) was purified from the fruit extract of Panax ginseng. Its chemical structure was measured by spectroscopic analysis, including HR-FAB-MS, 1H-NMR, and IR spectroscopy. Gin-Rb2 decreased potent melanogenesis in melan-a cells, with 23.4% at 80 μM without cytotoxicity. Gin-Rb2 also decreased tyrosinase and MITF protein expression in melan-a cells. Furthermore, Gin-Rb2 presented inhibition of the body pigmentation in the zebrafish in vivo system and reduced melanin contents and tyrosinase activity. These results show that Gin-Rb2 isolated from P. ginseng may be an effective skin-whitening agent via the in vitro and in vivo systems.",

keywords = "Ginsenoside Rb2, Melan-a cell, Melanin biosynthesis, Panax ginseng, Zebrafish",

author = "Lee, {Dae Young} and Jeong, {Yong Tae} and Jeong, {Sang Chul} and Lee, {Mi Kyoung} and Min, {Jin Woo} and Lee, {Jae Won} and Kim, {Geum Soog} and Lee, {Seung Eun} and Ahn, {Young Sup} and Kang, {Hee Cheol} and Kim, {Jin Hee}",

note = "Publisher Copyright: {\textcopyright} 2015 by The Korean Society for Microbiology and Biotechnology.",

year = "2015",

month = oct,

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doi = "10.4014/jmb.1505.05069",

language = "English",

volume = "25",

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T1 - Melanin biosynthesis inhibition effects of ginsenoside Rb2 isolated from panax ginseng berry

AU - Lee, Dae Young

AU - Jeong, Yong Tae

AU - Jeong, Sang Chul

AU - Lee, Mi Kyoung

AU - Min, Jin Woo

AU - Lee, Jae Won

AU - Kim, Geum Soog

AU - Lee, Seung Eun

AU - Ahn, Young Sup

AU - Kang, Hee Cheol

AU - Kim, Jin Hee

PY - 2015/10/6

Y1 - 2015/10/6

N2 - Ginsenoside Rb2 (Gin-Rb2) was purified from the fruit extract of Panax ginseng. Its chemical structure was measured by spectroscopic analysis, including HR-FAB-MS, 1H-NMR, and IR spectroscopy. Gin-Rb2 decreased potent melanogenesis in melan-a cells, with 23.4% at 80 μM without cytotoxicity. Gin-Rb2 also decreased tyrosinase and MITF protein expression in melan-a cells. Furthermore, Gin-Rb2 presented inhibition of the body pigmentation in the zebrafish in vivo system and reduced melanin contents and tyrosinase activity. These results show that Gin-Rb2 isolated from P. ginseng may be an effective skin-whitening agent via the in vitro and in vivo systems.

AB - Ginsenoside Rb2 (Gin-Rb2) was purified from the fruit extract of Panax ginseng. Its chemical structure was measured by spectroscopic analysis, including HR-FAB-MS, 1H-NMR, and IR spectroscopy. Gin-Rb2 decreased potent melanogenesis in melan-a cells, with 23.4% at 80 μM without cytotoxicity. Gin-Rb2 also decreased tyrosinase and MITF protein expression in melan-a cells. Furthermore, Gin-Rb2 presented inhibition of the body pigmentation in the zebrafish in vivo system and reduced melanin contents and tyrosinase activity. These results show that Gin-Rb2 isolated from P. ginseng may be an effective skin-whitening agent via the in vitro and in vivo systems.

KW - Ginsenoside Rb2

KW - Melan-a cell

KW - Melanin biosynthesis

KW - Panax ginseng

KW - Zebrafish

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DO - 10.4014/jmb.1505.05069

M3 - Article

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AN - SCOPUS:84949476752

SN - 1017-7825

VL - 25

SP - 2011

EP - 2015

JO - Journal of Microbiology and Biotechnology

JF - Journal of Microbiology and Biotechnology

IS - 12

ER -

Melanin biosynthesis inhibition effects of ginsenoside Rb2 isolated from panax ginseng berry

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Keywords

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