Membrane Proteins as a Regulator for Antibiotic Persistence in Gram-Negative Bacteria

Jia Xin Yee, Juhyun Kim, Jinki Yeom

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Antibiotic treatment failure threatens our ability to control bacterial infections that can cause chronic diseases. Persister bacteria are a subpopulation of physiological variants that becomes highly tolerant to antibiotics. Membrane proteins play crucial roles in all living organisms to regulate cellular physiology. Although a diverse membrane component involved in persistence can result in antibiotic treatment failure, the regulations of antibiotic persistence by membrane proteins has not been fully understood. In this review, we summarize the recent advances in our understanding with regards to membrane proteins in Gram-negative bacteria as a regulator for antibiotic persistence, highlighting various physiological mechanisms in bacteria.

Original languageEnglish
Pages (from-to)331-341
Number of pages11
JournalJournal of Microbiology
Volume61
Issue number3
DOIs
StatePublished - Mar 2023

Keywords

  • Antibiotics
  • Gram-negative bacteria
  • Membrane proteins
  • Pathogen
  • Persistence

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