Metabolism of saikosaponin c and naringin by human intestinal bacteria

Ki Ung Yu; Il Sung Jang; Keung Hyung Kang; Chung Ki Sung; Dong Hyun Kim

doi:10.1007/BF02973933

Metabolism of saikosaponin c and naringin by human intestinal bacteria

Ki Ung Yu, Il Sung Jang, Keung Hyung Kang, Chung Ki Sung, Dong Hyun Kim

Department of Dentistry

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

By human intestinal bacteria, saikosaponin c was transformed to four metabolites, prosaikogenin E1 (E1) prosaikogenin E2 (E2), prosaikogenin E3 (E3) and saikogenin E. Metabolic time course of saikosaponin c was as follows; in early time, saikosaponin c was converted to E1 and E2, and then these were transformed to saikogenin E via E3. Also, this metabolic pathway was similar to the metabolism of saikosaponin c by rat intestinal bacteria. Bacteroides JY-6 and Bacteroides YK-4, the bacteria isolated from human intestinal bacteria, could transform saikosaponin c to E via E1 (or E2) and E3. However, these bacteria were not able to directly transform E1 and E2 to saikogenin E. Naringin was mainly transformed to naringenin by human intestinal bacteria. The minor metabolic pathway transformed naringin to naringenin via prunin. By JY-6 or YK-4, naringin was metabolized to naringenin only via prunin.

Original language	English
Pages (from-to)	420-424
Number of pages	5
Journal	Archives of Pharmacal Research
Volume	20
Issue number	5
DOIs	https://doi.org/10.1007/BF02973933
State	Published - Oct 1997

Keywords

Bacteroides spp.
Intestinal bacteria
Naringin
Saikosaponin c

Access to Document

10.1007/BF02973933

Cite this

@article{98cc45e206564aaa857b8fd47530d3e4,

title = "Metabolism of saikosaponin c and naringin by human intestinal bacteria",

abstract = "By human intestinal bacteria, saikosaponin c was transformed to four metabolites, prosaikogenin E1 (E1) prosaikogenin E2 (E2), prosaikogenin E3 (E3) and saikogenin E. Metabolic time course of saikosaponin c was as follows; in early time, saikosaponin c was converted to E1 and E2, and then these were transformed to saikogenin E via E3. Also, this metabolic pathway was similar to the metabolism of saikosaponin c by rat intestinal bacteria. Bacteroides JY-6 and Bacteroides YK-4, the bacteria isolated from human intestinal bacteria, could transform saikosaponin c to E via E1 (or E2) and E3. However, these bacteria were not able to directly transform E1 and E2 to saikogenin E. Naringin was mainly transformed to naringenin by human intestinal bacteria. The minor metabolic pathway transformed naringin to naringenin via prunin. By JY-6 or YK-4, naringin was metabolized to naringenin only via prunin.",

keywords = "Bacteroides spp., Intestinal bacteria, Naringin, Saikosaponin c",

author = "Yu, {Ki Ung} and Jang, {Il Sung} and Kang, {Keung Hyung} and Sung, {Chung Ki} and Kim, {Dong Hyun}",

year = "1997",

month = oct,

doi = "10.1007/BF02973933",

language = "English",

volume = "20",

pages = "420--424",

journal = "Archives of Pharmacal Research",

issn = "0253-6269",

publisher = "Pharmaceutical Society of Korea",

number = "5",

}

TY - JOUR

T1 - Metabolism of saikosaponin c and naringin by human intestinal bacteria

AU - Yu, Ki Ung

AU - Jang, Il Sung

AU - Kang, Keung Hyung

AU - Sung, Chung Ki

AU - Kim, Dong Hyun

PY - 1997/10

Y1 - 1997/10

N2 - By human intestinal bacteria, saikosaponin c was transformed to four metabolites, prosaikogenin E1 (E1) prosaikogenin E2 (E2), prosaikogenin E3 (E3) and saikogenin E. Metabolic time course of saikosaponin c was as follows; in early time, saikosaponin c was converted to E1 and E2, and then these were transformed to saikogenin E via E3. Also, this metabolic pathway was similar to the metabolism of saikosaponin c by rat intestinal bacteria. Bacteroides JY-6 and Bacteroides YK-4, the bacteria isolated from human intestinal bacteria, could transform saikosaponin c to E via E1 (or E2) and E3. However, these bacteria were not able to directly transform E1 and E2 to saikogenin E. Naringin was mainly transformed to naringenin by human intestinal bacteria. The minor metabolic pathway transformed naringin to naringenin via prunin. By JY-6 or YK-4, naringin was metabolized to naringenin only via prunin.

AB - By human intestinal bacteria, saikosaponin c was transformed to four metabolites, prosaikogenin E1 (E1) prosaikogenin E2 (E2), prosaikogenin E3 (E3) and saikogenin E. Metabolic time course of saikosaponin c was as follows; in early time, saikosaponin c was converted to E1 and E2, and then these were transformed to saikogenin E via E3. Also, this metabolic pathway was similar to the metabolism of saikosaponin c by rat intestinal bacteria. Bacteroides JY-6 and Bacteroides YK-4, the bacteria isolated from human intestinal bacteria, could transform saikosaponin c to E via E1 (or E2) and E3. However, these bacteria were not able to directly transform E1 and E2 to saikogenin E. Naringin was mainly transformed to naringenin by human intestinal bacteria. The minor metabolic pathway transformed naringin to naringenin via prunin. By JY-6 or YK-4, naringin was metabolized to naringenin only via prunin.

KW - Bacteroides spp.

KW - Intestinal bacteria

KW - Naringin

KW - Saikosaponin c

UR - http://www.scopus.com/inward/record.url?scp=0344508908&partnerID=8YFLogxK

U2 - 10.1007/BF02973933

DO - 10.1007/BF02973933

M3 - Article

AN - SCOPUS:0344508908

SN - 0253-6269

VL - 20

SP - 420

EP - 424

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 5

ER -

Metabolism of saikosaponin c and naringin by human intestinal bacteria

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this