MHC class I transactivator NLRC5 in host immunity, cancer and beyond

Steven X. Cho; Saptha Vijayan; Ji Seung Yoo; Toshiyuki Watanabe; Ryota Ouda; Ning An; Koichi S. Kobayashi

doi:10.1111/imm.13235

MHC class I transactivator NLRC5 in host immunity, cancer and beyond

Steven X. Cho
, Saptha Vijayan
, Ji Seung Yoo
, Toshiyuki Watanabe
, Ryota Ouda
, Ning An
, Koichi S. Kobayashi

Hokkaido University
Texas A&M University

Research output: Contribution to journal › Review article › peer-review

37 Scopus citations

Abstract

The presentation of antigenic peptides by major histocompatibility complex (MHC) class I and class II molecules is crucial for activation of the adaptive immune system. The nucleotide-binding domain and leucine-rich repeat receptor family members CIITA and NLRC5 function as the major transcriptional activators of MHC class II and class I gene expression, respectively. Since the identification of NLRC5 as the master regulator of MHC class I and class-I-related genes, there have been major advances in understanding the function of NLRC5 in infectious diseases and cancer. Here, we discuss the biological significance and mechanism of NLRC5-dependent MHC class I expression.

Original language	English
Pages (from-to)	252-261
Number of pages	10
Journal	Immunology
Volume	162
Issue number	3
DOIs	https://doi.org/10.1111/imm.13235
State	Published - Mar 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cancer immune evasion
class I transactivator
major histocompatibility complex class I
regulatory factor X

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10.1111/imm.13235

Cite this

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title = "MHC class I transactivator NLRC5 in host immunity, cancer and beyond",

abstract = "The presentation of antigenic peptides by major histocompatibility complex (MHC) class I and class II molecules is crucial for activation of the adaptive immune system. The nucleotide-binding domain and leucine-rich repeat receptor family members CIITA and NLRC5 function as the major transcriptional activators of MHC class II and class I gene expression, respectively. Since the identification of NLRC5 as the master regulator of MHC class I and class-I-related genes, there have been major advances in understanding the function of NLRC5 in infectious diseases and cancer. Here, we discuss the biological significance and mechanism of NLRC5-dependent MHC class I expression.",

keywords = "cancer immune evasion, class I transactivator, major histocompatibility complex class I, regulatory factor X",

author = "Cho, \{Steven X.\} and Saptha Vijayan and Yoo, \{Ji Seung\} and Toshiyuki Watanabe and Ryota Ouda and Ning An and Kobayashi, \{Koichi S.\}",

note = "Publisher Copyright: {\textcopyright} 2020 John Wiley \& Sons Ltd",

year = "2021",

month = mar,

doi = "10.1111/imm.13235",

language = "English",

volume = "162",

pages = "252--261",

journal = "Immunology",

issn = "0019-2805",

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TY - JOUR

T1 - MHC class I transactivator NLRC5 in host immunity, cancer and beyond

AU - Cho, Steven X.

AU - Vijayan, Saptha

AU - Yoo, Ji Seung

AU - Watanabe, Toshiyuki

AU - Ouda, Ryota

AU - An, Ning

AU - Kobayashi, Koichi S.

PY - 2021/3

Y1 - 2021/3

N2 - The presentation of antigenic peptides by major histocompatibility complex (MHC) class I and class II molecules is crucial for activation of the adaptive immune system. The nucleotide-binding domain and leucine-rich repeat receptor family members CIITA and NLRC5 function as the major transcriptional activators of MHC class II and class I gene expression, respectively. Since the identification of NLRC5 as the master regulator of MHC class I and class-I-related genes, there have been major advances in understanding the function of NLRC5 in infectious diseases and cancer. Here, we discuss the biological significance and mechanism of NLRC5-dependent MHC class I expression.

AB - The presentation of antigenic peptides by major histocompatibility complex (MHC) class I and class II molecules is crucial for activation of the adaptive immune system. The nucleotide-binding domain and leucine-rich repeat receptor family members CIITA and NLRC5 function as the major transcriptional activators of MHC class II and class I gene expression, respectively. Since the identification of NLRC5 as the master regulator of MHC class I and class-I-related genes, there have been major advances in understanding the function of NLRC5 in infectious diseases and cancer. Here, we discuss the biological significance and mechanism of NLRC5-dependent MHC class I expression.

KW - cancer immune evasion

KW - class I transactivator

KW - major histocompatibility complex class I

KW - regulatory factor X

UR - https://www.scopus.com/pages/publications/85088872280

U2 - 10.1111/imm.13235

DO - 10.1111/imm.13235

M3 - Review article

C2 - 32633419

AN - SCOPUS:85088872280

SN - 0019-2805

VL - 162

SP - 252

EP - 261

JO - Immunology

JF - Immunology

IS - 3

ER -

MHC class I transactivator NLRC5 in host immunity, cancer and beyond

Abstract

UN SDGs

Keywords

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