Microcystic stromal tumor of the ovary with mutation in exon 3 of β-catenin: A case report

Yu Na Kang, Chi Heum Cho, Sun Young Kwon

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26 Scopus citations

Abstract

Microcystic stromal tumor of the ovary is a very rare ovarian tumor with distinctive microcystic histologic features and a characteristic immunophenotype of stromal tumor. However, its origin, tumor pathogenesis, and prognosis have not been well established until now. We report a very unusual case of a microcystic stromal tumor of the ovary with a mutation in exon 3 of the β-catenin (CTNNB1) gene. Macroscopically, the fragmented ovarian tumor showed a diffuse solid mass. Microscopically, the tumor had a pathognomonic histologic pattern of solid and cellular areas with microcysts and fibrous hyalinized stroma. Immunohistochemical staining with CD10, vimentin, CD99, and β-catenin showed positive expression. However, α-inhibin and E-cadherin showed negativity. Mutational analysis revealed a point mutation in exon 3 of the β-catenin (CTNNB1) gene.

Original languageEnglish
Pages (from-to)121-125
Number of pages5
JournalInternational Journal of Gynecological Pathology
Volume34
Issue number2
DOIs
StatePublished - 28 Feb 2015

Keywords

  • Microcystic stromal tumor
  • Mutation
  • Ovary
  • β-Catenin

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