Microencapsulation of pluripotent stem cell-derived pancreatic and liver cells: biological needs and technological solutions

Kianna Nguyen; Quang Tuan Che; Quoc Huynh Nguyen; Kihak Gwon; Alan Gonzalez Suarez; Gulnaz Stybayeva; Robert Huebert; Quinn Peterson; Alexander Revzin

doi:10.1039/d5bm00696a

Microencapsulation of pluripotent stem cell-derived pancreatic and liver cells: biological needs and technological solutions

Kianna Nguyen
, Quang Tuan Che
, Quoc Huynh Nguyen
, Kihak Gwon
, Alan Gonzalez Suarez
, Gulnaz Stybayeva
, Robert Huebert
, Quinn Peterson
, Alexander Revzin

Department of Biofibers and Biomaterials Science

Mayo Clinic College of Medicine and Science
Mayo Clinic Rochester, MN

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Pluripotent stem cell-derived products are versatile tools for studying disease and developing cellular therapies. Microencapsulation technologies offer solutions for scalability, prolonged survival, and transplantability of these stem-cell derived products. This review describes current methods and materials utilized for stem cell encapsulation. Specifically, the differentiation of stem cell-derived β cells and hepatocytes is explored. This includes the current state of differentiation protocols, examples of microencapsulation for differentiation and transplantation, and future directions.

Original language	English
Pages (from-to)	4003-4023
Number of pages	21
Journal	Biomaterials Science
Volume	13
Issue number	15
DOIs	https://doi.org/10.1039/d5bm00696a
State	Published - 22 Jul 2025

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10.1039/d5bm00696a

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abstract = "Pluripotent stem cell-derived products are versatile tools for studying disease and developing cellular therapies. Microencapsulation technologies offer solutions for scalability, prolonged survival, and transplantability of these stem-cell derived products. This review describes current methods and materials utilized for stem cell encapsulation. Specifically, the differentiation of stem cell-derived β cells and hepatocytes is explored. This includes the current state of differentiation protocols, examples of microencapsulation for differentiation and transplantation, and future directions.",

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T2 - biological needs and technological solutions

AU - Nguyen, Kianna

AU - Che, Quang Tuan

AU - Nguyen, Quoc Huynh

AU - Gwon, Kihak

AU - Gonzalez Suarez, Alan

AU - Stybayeva, Gulnaz

AU - Huebert, Robert

AU - Peterson, Quinn

AU - Revzin, Alexander

PY - 2025/7/22

Y1 - 2025/7/22

N2 - Pluripotent stem cell-derived products are versatile tools for studying disease and developing cellular therapies. Microencapsulation technologies offer solutions for scalability, prolonged survival, and transplantability of these stem-cell derived products. This review describes current methods and materials utilized for stem cell encapsulation. Specifically, the differentiation of stem cell-derived β cells and hepatocytes is explored. This includes the current state of differentiation protocols, examples of microencapsulation for differentiation and transplantation, and future directions.

AB - Pluripotent stem cell-derived products are versatile tools for studying disease and developing cellular therapies. Microencapsulation technologies offer solutions for scalability, prolonged survival, and transplantability of these stem-cell derived products. This review describes current methods and materials utilized for stem cell encapsulation. Specifically, the differentiation of stem cell-derived β cells and hepatocytes is explored. This includes the current state of differentiation protocols, examples of microencapsulation for differentiation and transplantation, and future directions.

UR - https://www.scopus.com/pages/publications/105008577190

U2 - 10.1039/d5bm00696a

DO - 10.1039/d5bm00696a

M3 - Review article

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AN - SCOPUS:105008577190

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SP - 4003

EP - 4023

JO - Biomaterials Science

JF - Biomaterials Science

IS - 15

ER -

Microencapsulation of pluripotent stem cell-derived pancreatic and liver cells: biological needs and technological solutions

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