Microencapsulation of pluripotent stem cell-derived pancreatic and liver cells: biological needs and technological solutions

Kianna Nguyen; Quang Tuan Che; Quoc Huynh Nguyen; Kihak Gwon; Alan Gonzalez Suarez; Gulnaz Stybayeva; Robert Huebert; Quinn Peterson; Alexander Revzin

doi:10.1039/d5bm00696a

Microencapsulation of pluripotent stem cell-derived pancreatic and liver cells: biological needs and technological solutions

Kianna Nguyen, Quang Tuan Che, Quoc Huynh Nguyen, Kihak Gwon, Alan Gonzalez Suarez, Gulnaz Stybayeva, Robert Huebert, Quinn Peterson, Alexander Revzin

Department of Biofibers and Biomaterials Science

Research output: Contribution to journal › Review article › peer-review

Abstract

Pluripotent stem cell-derived products are versatile tools for studying disease and developing cellular therapies. Microencapsulation technologies offer solutions for scalability, prolonged survival, and transplantability of these stem-cell derived products. This review describes current methods and materials utilized for stem cell encapsulation. Specifically, the differentiation of stem cell-derived β cells and hepatocytes is explored. This includes the current state of differentiation protocols, examples of microencapsulation for differentiation and transplantation, and future directions.

Original language	English
Pages (from-to)	4003-4023
Number of pages	21
Journal	Biomaterials Science
Volume	13
Issue number	15
DOIs	https://doi.org/10.1039/d5bm00696a
State	Published - 22 Jul 2025

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title = "Microencapsulation of pluripotent stem cell-derived pancreatic and liver cells: biological needs and technological solutions",

abstract = "Pluripotent stem cell-derived products are versatile tools for studying disease and developing cellular therapies. Microencapsulation technologies offer solutions for scalability, prolonged survival, and transplantability of these stem-cell derived products. This review describes current methods and materials utilized for stem cell encapsulation. Specifically, the differentiation of stem cell-derived β cells and hepatocytes is explored. This includes the current state of differentiation protocols, examples of microencapsulation for differentiation and transplantation, and future directions.",

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T1 - Microencapsulation of pluripotent stem cell-derived pancreatic and liver cells

T2 - biological needs and technological solutions

AU - Nguyen, Kianna

AU - Che, Quang Tuan

AU - Nguyen, Quoc Huynh

AU - Gwon, Kihak

AU - Gonzalez Suarez, Alan

AU - Stybayeva, Gulnaz

AU - Huebert, Robert

AU - Peterson, Quinn

AU - Revzin, Alexander

PY - 2025/7/22

Y1 - 2025/7/22

N2 - Pluripotent stem cell-derived products are versatile tools for studying disease and developing cellular therapies. Microencapsulation technologies offer solutions for scalability, prolonged survival, and transplantability of these stem-cell derived products. This review describes current methods and materials utilized for stem cell encapsulation. Specifically, the differentiation of stem cell-derived β cells and hepatocytes is explored. This includes the current state of differentiation protocols, examples of microencapsulation for differentiation and transplantation, and future directions.

AB - Pluripotent stem cell-derived products are versatile tools for studying disease and developing cellular therapies. Microencapsulation technologies offer solutions for scalability, prolonged survival, and transplantability of these stem-cell derived products. This review describes current methods and materials utilized for stem cell encapsulation. Specifically, the differentiation of stem cell-derived β cells and hepatocytes is explored. This includes the current state of differentiation protocols, examples of microencapsulation for differentiation and transplantation, and future directions.

UR - https://www.scopus.com/pages/publications/105008577190

U2 - 10.1039/d5bm00696a

DO - 10.1039/d5bm00696a

M3 - Review article

C2 - 40524668

AN - SCOPUS:105008577190

SN - 2047-4830

VL - 13

SP - 4003

EP - 4023

JO - Biomaterials Science

JF - Biomaterials Science

IS - 15

ER -

Microencapsulation of pluripotent stem cell-derived pancreatic and liver cells: biological needs and technological solutions

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