Microwave-assisted green construction of imidazole-fused hybrid scaffolds using 2-aminobenzimidazoles as building blocks

Jung Pyo Kwak; Pham Duy Quang Dao; Nam Sik Yoon; Chan Sik Cho

doi:10.1039/d1ra04396j

Microwave-assisted green construction of imidazole-fused hybrid scaffolds using 2-aminobenzimidazoles as building blocks

Jung Pyo Kwak, Pham Duy Quang Dao, Nam Sik Yoon, Chan Sik Cho

Department of Applied Chemistry

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

A class of trinuclear imidazole-fused hybrid scaffolds was constructed by the reaction of 2-(2-bromoaryl)- and 2-(2-bromovinyl)imidazoles with 2-aminobenzimidazoles as building blocks in the presence of a base under microwave irradiation. A nucleophilic aromatic substitution followed by cyclization is proposed as a reaction pathway of this green process.

Original language	English
Pages (from-to)	21367-21374
Number of pages	8
Journal	RSC Advances
Volume	11
Issue number	35
DOIs	https://doi.org/10.1039/d1ra04396j
State	Published - 17 Jun 2021

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abstract = "A class of trinuclear imidazole-fused hybrid scaffolds was constructed by the reaction of 2-(2-bromoaryl)- and 2-(2-bromovinyl)imidazoles with 2-aminobenzimidazoles as building blocks in the presence of a base under microwave irradiation. A nucleophilic aromatic substitution followed by cyclization is proposed as a reaction pathway of this green process.",

author = "Kwak, {Jung Pyo} and {Quang Dao}, {Pham Duy} and Yoon, {Nam Sik} and Cho, {Chan Sik}",

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AU - Kwak, Jung Pyo

AU - Quang Dao, Pham Duy

AU - Yoon, Nam Sik

AU - Cho, Chan Sik

PY - 2021/6/17

Y1 - 2021/6/17

N2 - A class of trinuclear imidazole-fused hybrid scaffolds was constructed by the reaction of 2-(2-bromoaryl)- and 2-(2-bromovinyl)imidazoles with 2-aminobenzimidazoles as building blocks in the presence of a base under microwave irradiation. A nucleophilic aromatic substitution followed by cyclization is proposed as a reaction pathway of this green process.

AB - A class of trinuclear imidazole-fused hybrid scaffolds was constructed by the reaction of 2-(2-bromoaryl)- and 2-(2-bromovinyl)imidazoles with 2-aminobenzimidazoles as building blocks in the presence of a base under microwave irradiation. A nucleophilic aromatic substitution followed by cyclization is proposed as a reaction pathway of this green process.

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DO - 10.1039/d1ra04396j

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Microwave-assisted green construction of imidazole-fused hybrid scaffolds using 2-aminobenzimidazoles as building blocks

Abstract

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