miR-93/miR-106b/miR-375-CIC-CRABP1: A novel regulatory axis in prostate cancer progression

Nahyun Choi, Jongmin Park, Jeon Soo Lee, Jeehyun Yoe, Guk Yeol Park, Eunjeong Kim, Hyeongrin Jeon, Yong Mee Cho, Tae Young Roh, Yoontae Lee

Research output: Contribution to journalArticlepeer-review

81 Scopus citations

Abstract

Capicua (CIC) has been implicated in pathogenesis of spinocerebellar ataxia type-1 (SCA1) neurodegenerative disease and some types of cancer; however, the role of CIC in prostate cancer remains unknown. Here we show that CIC suppresses prostate cancer progression. CIC expression was markedly decreased in human prostatic carcinoma. CIC overexpression suppressed prostate cancer cell proliferation, invasion, and migration, whereas CIC RNAi exerted opposite effects. We found that knock-down of CIC derepresses expression of ETV5 and CRABP1 in LNCaP and PC-3 cells, respectively, thereby promoting cell proliferation and invasion. We also discovered that miR-93, miR-106b, and miR-375, which are known to be frequently overexpressed in prostate cancer patients, cooperatively down-regulate CIC levels to promote cancer progression. Altogether, we suggest miR-93/miR-106b/miR-375- CIC-CRABP1 as a novel key regulatory axis in prostate cancer progression.

Original languageEnglish
Pages (from-to)23533-23547
Number of pages15
JournalOncotarget
Volume6
Issue number27
DOIs
StatePublished - 2015

Keywords

  • Capicua
  • CRABP1
  • ETV5
  • MicroRNA
  • Prostate cancer

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