Mitochondrial and Metabolic Adaptations to Exercise-Induced Fluid Shear Stress in Endothelial Cells

Soon Gook Hong; Junchul Shin; Maitha Aldokhayyil; Michael David Brown; Joon Young Park

doi:10.1249/JES.0000000000000289

Mitochondrial and Metabolic Adaptations to Exercise-Induced Fluid Shear Stress in Endothelial Cells

Soon Gook Hong, Junchul Shin, Maitha Aldokhayyil, Michael David Brown, Joon Young Park

Department of Kinesiology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Recent studies have greatly advanced our understanding of the central role of mitochondria on endothelial function. Here, we propose a hypothesis that unidirectional laminar (pulsatile) flow and disturbed laminar (oscillatory) flow may differentially modulate mitochondrial phenotypes in the context of their bioenergetic, signaling, and biosynthetic functions, providing novel insights into subcellular mechanisms underlying how exercise benefits the improvement of vascular health.

Original language	English
Pages (from-to)	145-155
Number of pages	11
Journal	Exercise and Sport Sciences Reviews
Volume	50
Issue number	3
DOIs	https://doi.org/10.1249/JES.0000000000000289
State	Published - 1 Jul 2022

Keywords

cell metabolism
endothelial cell
fluid shear stress
mitochondrion
mitophagy

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10.1249/JES.0000000000000289

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abstract = "Recent studies have greatly advanced our understanding of the central role of mitochondria on endothelial function. Here, we propose a hypothesis that unidirectional laminar (pulsatile) flow and disturbed laminar (oscillatory) flow may differentially modulate mitochondrial phenotypes in the context of their bioenergetic, signaling, and biosynthetic functions, providing novel insights into subcellular mechanisms underlying how exercise benefits the improvement of vascular health.",

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author = "Hong, {Soon Gook} and Junchul Shin and Maitha Aldokhayyil and Brown, {Michael David} and Park, {Joon Young}",

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AU - Brown, Michael David

AU - Park, Joon Young

PY - 2022/7/1

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KW - cell metabolism

KW - endothelial cell

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KW - mitophagy

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Mitochondrial and Metabolic Adaptations to Exercise-Induced Fluid Shear Stress in Endothelial Cells

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Keywords

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