Mixed micelle-template route to mesoporous silica

You Hwan Son; Man Park; Sang Tae Kim; Jin Ho Choy

doi:10.1166/jnn.2007.037

Mixed micelle-template route to mesoporous silica

You Hwan Son, Man Park, Sang Tae Kim, Jin Ho Choy

School of Applied Bioscience

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Mesoporous silica materials were prepared through a novel mixed micelle-template method which was employed by alkyl polyethylene oxide (C ₁₆E ₂₀) and C ₂-ceramide. X-ray diffraction patterns clearly showed the formation of mesoporous silica by contribution of mixed micelle-template up to 3/1 weight ratio (C ₁₆E ₂₀/C ₂-ceramide). TEM and N ₂ adsorption isotherms analyses indicated that the mesoporous structure was maintained even after encased C ₂-ceramides. However, when the weight ratio of C ₁₆E ₂₀/C ₂-ceramide exceeds 2/2, less ordered and irregular pore structure was observed. According to the in-vitro experiment on cancer cells such as MCF-7, HOS, and HepG2, the simultaneously encapsulated C ₂-ceramide shows apoptosis. Therefore, the present results could provide a new method for mesoporous material as drug delivery system.

Original language	English
Pages (from-to)	3819-3822
Number of pages	4
Journal	Journal of Nanoscience and Nanotechnology
Volume	7
Issue number	11
DOIs	https://doi.org/10.1166/jnn.2007.037
State	Published - Nov 2007

Keywords

Cell viability
Delivery
Drug
Mixed micelle
Template

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1166/jnn.2007.037

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title = "Mixed micelle-template route to mesoporous silica",

abstract = "Mesoporous silica materials were prepared through a novel mixed micelle-template method which was employed by alkyl polyethylene oxide (C 16E 20) and C 2-ceramide. X-ray diffraction patterns clearly showed the formation of mesoporous silica by contribution of mixed micelle-template up to 3/1 weight ratio (C 16E 20/C 2-ceramide). TEM and N 2 adsorption isotherms analyses indicated that the mesoporous structure was maintained even after encased C 2-ceramides. However, when the weight ratio of C 16E 20/C 2-ceramide exceeds 2/2, less ordered and irregular pore structure was observed. According to the in-vitro experiment on cancer cells such as MCF-7, HOS, and HepG2, the simultaneously encapsulated C 2-ceramide shows apoptosis. Therefore, the present results could provide a new method for mesoporous material as drug delivery system.",

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AU - Son, You Hwan

AU - Park, Man

AU - Kim, Sang Tae

AU - Choy, Jin Ho

PY - 2007/11

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N2 - Mesoporous silica materials were prepared through a novel mixed micelle-template method which was employed by alkyl polyethylene oxide (C 16E 20) and C 2-ceramide. X-ray diffraction patterns clearly showed the formation of mesoporous silica by contribution of mixed micelle-template up to 3/1 weight ratio (C 16E 20/C 2-ceramide). TEM and N 2 adsorption isotherms analyses indicated that the mesoporous structure was maintained even after encased C 2-ceramides. However, when the weight ratio of C 16E 20/C 2-ceramide exceeds 2/2, less ordered and irregular pore structure was observed. According to the in-vitro experiment on cancer cells such as MCF-7, HOS, and HepG2, the simultaneously encapsulated C 2-ceramide shows apoptosis. Therefore, the present results could provide a new method for mesoporous material as drug delivery system.

AB - Mesoporous silica materials were prepared through a novel mixed micelle-template method which was employed by alkyl polyethylene oxide (C 16E 20) and C 2-ceramide. X-ray diffraction patterns clearly showed the formation of mesoporous silica by contribution of mixed micelle-template up to 3/1 weight ratio (C 16E 20/C 2-ceramide). TEM and N 2 adsorption isotherms analyses indicated that the mesoporous structure was maintained even after encased C 2-ceramides. However, when the weight ratio of C 16E 20/C 2-ceramide exceeds 2/2, less ordered and irregular pore structure was observed. According to the in-vitro experiment on cancer cells such as MCF-7, HOS, and HepG2, the simultaneously encapsulated C 2-ceramide shows apoptosis. Therefore, the present results could provide a new method for mesoporous material as drug delivery system.

KW - Cell viability

KW - Delivery

KW - Drug

KW - Mixed micelle

KW - Template

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JO - Journal of Nanoscience and Nanotechnology

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Mixed micelle-template route to mesoporous silica

Abstract

Keywords

UN SDGs

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