Mono and Multiple Tumor-Targeting Ligand-Coated Ultrasmall Gadolinium Oxide Nanoparticles: Enhanced Tumor Imaging and Blood Circulation

Son Long Ho, Huan Yue, Sangyeol Lee, Tirusew Tegafaw, Mohammad Yaseen Ahmad, Shuwen Liu, Abdullah Khamis Ali Al Saidi, Dejun Zhao, Ying Liu, Sung Wook Nam, Kwon Seok Chae, Yongmin Chang, Gang Ho Lee

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Hydrophilic and biocompatible PAA-coated ultrasmall Gd2O3 nanoparticles (davg = 1.7 nm) were synthesized and conjugated with tumor-targeting ligands, i.e., cyclic arginylglycylaspartic acid (cRGD) and/or folic acid (FA). FA-PAA-Gd2O3 and cRGD/FA-PAA-Gd2O3 nanoparticles were successfully applied in U87MG tumor-bearing mice for tumor imaging using T1 magnetic resonance imaging (MRI). cRGD/FA-PAA-Gd2O3 nanoparticles with multiple tumor-targeting ligands exhibited higher contrasts at the tumor site than FA-PAA-Gd2O3 nanoparticles with mono tumor-targeting ligands. In addition, the cRGD/FA-PAA-Gd2O3 nanoparticles exhibited higher contrasts in all organs, especially the aorta, compared with those of the FA-PAA-Gd2O3 nanoparticles, because of the blood cell hitchhiking effect of cRGD in the cRGD/FA-PAA-Gd2O3 nanoparticles, which prolonged their circulation in the blood.

Original languageEnglish
Article number1458
JournalPharmaceutics
Volume14
Issue number7
DOIs
StatePublished - Jul 2022

Keywords

  • blood circulation enhancement
  • cRGD
  • folic acid
  • multiple tumor-targeting ligand
  • tumor imaging
  • ultrasmall GdO nanoparticle

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