Monodispersed Fe-Pt nanoparticles for biomedical applications

Monodispersed Fe-Pt nanoparticles are promising candidates for biomedical applications with an average particle diameter of 6.9 nm Fe48 Pt52, 3.3 nm Fe52 Pt48, and 4.2 nm Fe70 Pt30. They are prepared by simultaneous chemical reduction of Pt (acac)2 and thermal decomposition of Fe (CO)5 in the presence of surfactant as an anti-oxidation reagent and amine as a stabilizer. The blocking temperatures, Tb, of 9 K for Fe70 Pt30, 11 K for Fe52 Pt48 and 14.4 K for Fe48 Pt52 and the mean diameter of the spherical magnetic particles were estimated from the calculated volume to be 3.6, 3.1, and 3.8 nm. The cytotoxicity of unmodified Fe-Pt nanoparticles was performed in brain endothelial cells. Fe48 Pt52 nanoparticles were not found to have any significant toxicity on bEnd3 cells during a 24 h period.