Mosquito larvicidal activity of pipernonaline, a piperidine alkaloid derived from long pepper, Piper longum

Sung Eun Lee

Mosquito larvicidal activity of pipernonaline, a piperidine alkaloid derived from long pepper, Piper longum

Sung Eun Lee

School of Applied Bioscience

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

A methanol extract of Piper longum fruit was found to be active against mosquito larvae of Culex pipiens pallens at 10 μg/ml after 24 h. A piperidine alkaloid, pipernonaline, was found to be responsible for this activity, with the 24-h median lethal dose (LD₅₀) value for this compound being 0.21 mg/liter. The LD₅₀ value of pipernonaline was not much higher than those for the 3 organophosphorous insecticides malathion, chlorpyrifos-methyl, and pirimiphos-methyl, used for comparative purpose in this study. Structural elucidation of pipernonaline was by means of mass spectrometry (¹H and ¹¹C nuclear magnetic resonance imaging).

Original language	English
Pages (from-to)	245-247
Number of pages	3
Journal	Journal of the American Mosquito Control Association
Volume	16
Issue number	3
State	Published - Sep 2000

Keywords

Culex pipiens
Mosquito larvicidal activity
Piper longum
Pipernonaline

Cite this

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title = "Mosquito larvicidal activity of pipernonaline, a piperidine alkaloid derived from long pepper, Piper longum",

abstract = "A methanol extract of Piper longum fruit was found to be active against mosquito larvae of Culex pipiens pallens at 10 μg/ml after 24 h. A piperidine alkaloid, pipernonaline, was found to be responsible for this activity, with the 24-h median lethal dose (LD50) value for this compound being 0.21 mg/liter. The LD50 value of pipernonaline was not much higher than those for the 3 organophosphorous insecticides malathion, chlorpyrifos-methyl, and pirimiphos-methyl, used for comparative purpose in this study. Structural elucidation of pipernonaline was by means of mass spectrometry (1H and 11C nuclear magnetic resonance imaging).",

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T1 - Mosquito larvicidal activity of pipernonaline, a piperidine alkaloid derived from long pepper, Piper longum

AU - Lee, Sung Eun

PY - 2000/9

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N2 - A methanol extract of Piper longum fruit was found to be active against mosquito larvae of Culex pipiens pallens at 10 μg/ml after 24 h. A piperidine alkaloid, pipernonaline, was found to be responsible for this activity, with the 24-h median lethal dose (LD50) value for this compound being 0.21 mg/liter. The LD50 value of pipernonaline was not much higher than those for the 3 organophosphorous insecticides malathion, chlorpyrifos-methyl, and pirimiphos-methyl, used for comparative purpose in this study. Structural elucidation of pipernonaline was by means of mass spectrometry (1H and 11C nuclear magnetic resonance imaging).

AB - A methanol extract of Piper longum fruit was found to be active against mosquito larvae of Culex pipiens pallens at 10 μg/ml after 24 h. A piperidine alkaloid, pipernonaline, was found to be responsible for this activity, with the 24-h median lethal dose (LD50) value for this compound being 0.21 mg/liter. The LD50 value of pipernonaline was not much higher than those for the 3 organophosphorous insecticides malathion, chlorpyrifos-methyl, and pirimiphos-methyl, used for comparative purpose in this study. Structural elucidation of pipernonaline was by means of mass spectrometry (1H and 11C nuclear magnetic resonance imaging).

KW - Culex pipiens

KW - Mosquito larvicidal activity

KW - Piper longum

KW - Pipernonaline

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AN - SCOPUS:0034267982

SN - 8756-971X

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JO - Journal of the American Mosquito Control Association

JF - Journal of the American Mosquito Control Association

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ER -

Mosquito larvicidal activity of pipernonaline, a piperidine alkaloid derived from long pepper, Piper longum

Abstract

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